Category: Home

Quercetin and anti-viral properties

Quercetin and anti-viral properties

Anto-viral J, Cinatl J, Weber B, Propertirs H, Gumbel H, Chenot J, et al. Powell Quercetim, Warner NE, Levine RS, Kirsner JB Prooerties inclusion disease and ulcerative prroperties Quercetin and anti-viral properties of Electrolyte balance and muscle function case in a young adult. Natural flavones include apigenin, baicalein, chrysin, luteolin, scutellarein, tangeritin, wogonin and 6-hydroxyflavone. Cell Death Dis 6:e However, even though QQ exhibits a higher affinity for glutathione than for vitamin Cthe methylated metabolites of quercetin show a higher preference for ascorbate than for thiols, suggesting a cycling of activity which will exert anti-oxidant effects Figure 2

Quercetin and anti-viral properties -

Hence, efforts in enhancing the bioavailability of flavonoids upon intake by humans are vitally necessary in order to develop these natural compounds into potential antiviral drugs. The following are a few examples of efforts being carried out to tackle this issue which can be used as platforms for further successes in the future.

A structural modification to hesperetinglucoside, which resulted in a change in site of absorption from the large to the small intestine, has successfully yielded a higher plasma level of hesperetin in healthy subjects [ ]. Wang et al. Flavonoids loaded in engineered nanoparticles have also been tested for their bioavailability following oral consumption.

Improved stability of catechin and EGCG in chitosan nanoparticles have been shown to result in a higher rate of intestinal absorption [ 29 ]. Poly D, L-Lactide PLA nanoparticles and polymeric micelles contributed to a more sustainable release of quercetin, which has poor bioavailability and undergoes substantial first-pass metabolism, as well as of the poorly absorbed apigenin [ 70 , , ].

Self-Microemulsifying Drug Delivery System SMDDS is another technology which has been used to overcome the problem of low bioavailability of hydrophobic molecules. Upon entering the lumen of the intestine, an oil-in-water microemulsion containing the drug will be formed.

The microemulsion increases the intestinal absorption of the drug or compound by avoiding the dissolution process [ 60 , ].

Puerarin, an isoflavone isolated from the root of Pueraria lobata , exhibited 2. However, it is worth noting that while the bioavailability of flavonoids can be increased via different methodologies, it is vital that their biological efficacies are not affected, but maintained or enhanced.

For instance, phosphorylated icariin has been found to inhibit duck hepatitis virus A more effectively than the parent compound [ ]. Isorhamnetin is a methylated flavonol derived from the structure of quercetin. Dayem et al. investigated the antiviral potency of isorhamnetin against influenza A H1N1 virus and discovered that the methyl group on the B ring enhances its antiviral activity compared with the other tested flavonoids [ 25 ].

The efficacy of isorhamnetin against influenza virus was also shown when in vivo and in ovo models were tested [ 25 ]. Improvement in bioavailability will definitely enhance the efficacy of different biological effects of all classes of flavonoids.

Hence, in addition to discovering the hidden potentials of flavonoids, scientists should also aim to identify ways to increase the amount of flavonoids available for the health benefits of human beings.

Natural compounds have been the center of attention among researchers working in various fields, including those related with antiviral drug development, due to their high availability and low side effects.

The phytochemicals flavonoids, which are abundantly found in our daily diets of fruits and vegetables, have been actively studied as potential therapeutic options against viruses of different taxa in the past decade.

Numerous positive findings have been reported on the in vitro efficacy of flavonoids, but less promising results have been obtained for most compounds in in vivo studies.

Multiple factors contributed to this scenario, and in vivo studies must be prioritized by researchers. It is well-known that flavonoids possess enormous potential to be included in the daily prescriptions by physicians treating illnesses ranging from infectious and oncogenic to inflammatory and chronic degenerative diseases.

However, it is time for researchers worldwide to take the initiative in making these compounds a success not only in the in vitro stage of research, but also in animal models, as well as in subsequent clinical studies.

Ahmadi A, Hassandarvish P, Lani R, Yadollahi P, Jokar A, Bakar SA, Zandi K Inhibition of chikungunya virus replication by hesperetin and naringenin.

RSC Adv — doi: Article CAS Google Scholar. Akula SM, Hurley DJ, Wixon RL, Wang C, Chase CC Effect of genistein on replication of bovine herpesvirus type 1.

Am J Vet Res 63 8 — Article CAS PubMed Google Scholar. Argenta DF, Silva IT, Bassani VL, Koester LS, Teixeira HF, Simões CM Antiherpes evaluation of soybean isoflavonoids.

Arch Virol 9 — Bachmetov L, Gal-Tanamy M, Shapira A, Vorobeychik M, Giterman-Galam T, Sathiyamoorthy P, Golan-Goldhirsh A, Benhar I, Tur-Kaspa R, Zemel R Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity.

J Viral Hepat 19 2 :e81—e Behbahani M, Sayedipour S, Pourazar A, Shanehsazzadeh M In vitro anti-HIV-1 activities of kaempferol and kaempferolO-glucoside isolated from Securigera securidaca.

Res Pharm Sci 9 6 — CAS PubMed PubMed Central Google Scholar. Bowles D, Isayenkova J, Lim EK, Poppenberger B Glycosyltransferases: managers of small molecules. Curr Opin Plant Biol 8 3 — Bullock AN, Debreczeni JÉ, Fedorov OY, Nelson A, Marsden BD, Knapp S Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus PIM-1 kinase.

J Med Chem — Hepatology 55 3 — Carletti G, Nervo G, Cattivelli L Flavonoids and Melanins: a common strategy across two kingdoms. Int J Biol Sci 10 10 — Article CAS PubMed PubMed Central Google Scholar.

Carneiro BM, Batista MN, Braga ACS, Nogueira ML, Rahal P The green tea molecule EGCG inhibits Zika virus entry. Virology — Carvalho OV, Botelho CV, Ferreira CG, Ferreira HC, Santos MR, Diaz MA, Oliveira TT, Soares-Martins JA, Almeida MR, Silva A Jr In vitro inhibition of canine distemper virus by flavonoids and phenolic acids: implications of structural differences for antiviral design.

Res Vet Sci 95 2 — Castrillo M, Córdova T, Cabrera G, Rodríguez-Ortega M Effect of naringenin, hesperetin and their glycosides forms on the replication of the 17D strain of yellow fever virus. Avan Biomed — Google Scholar. Biochem Biophys Res Commun 4 — Chantrill BH, Coulthard CE, Dickinson L, Inkley GW, Morris W, Pyle AH The action of plant extracts on a bacteriophage of Pseudomonas pyocyanea and on influenza A virus.

J Gen Microbiol — Arch Virol 7 — Chiang LC, Chiang W, Liu MC, Lin CC In vitro antiviral activities of Caesalpinia pulcherrima and its related flavonoids.

J Antimicrob Chemother 52 2 — Chiang LC, Ng LT, Cheng PW, Chiang W, Lin CC Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. Clin Exp Pharmacol Physiol — Cho WK, Weeratunga P, Lee BH, Park JS, Kim CJ, Ma JY, Lee JS Epimedium koreanum Nakai displays broad spectrum of antiviral activity in vitro and in vivo by inducing cellular antiviral state.

Viruses 7 1 — Article PubMed PubMed Central CAS Google Scholar. Chu M, Xu L, Zhang MB, Chu ZY, Wang YD Role of Baicalin in anti-influenza virus A as a potent inducer of IFN-gamma. Biomed Res Int PubMed PubMed Central Google Scholar.

Chu SC, Hsieh YS, Lin JY Inhibitory effects of flavonoids on Moloney murine leukemia virus reverse transcriptase activity. J Nat Prod 55 2 — Chung ST, Chien PY, Huang WH, Yao CW, Lee AR Synthesis and anti-influenza activities of novel baicalein analogs.

Chem Pharm Bull Tokyo 62 5 — Colpitts CC, Schang LM A small molecule inhibits virion attachment to heparan sulfate- or sialic acid-containing glycans.

J Virol 88 14 — Cotin S, Calliste CA, Mazeron MC, Hantz S, Duroux JL, Rawlinson WD, Ploy MC, Alain S Eight flavonoids and their potential as inhibitors of human cytomegalovirus replication. Antiviral Res 96 2 — Croft KD The chemistry and biological effects of flavonoids and phenolic acids.

Ann N Y Acad Sci — Dayem AA, Choi HY, Kim YB, Cho S-G Antiviral effect of methylated flavonol isorhamnetin against influenza. PLoS One e Article PubMed Central CAS Google Scholar.

Arch Virol 12 — dos Santos AE, Kuster RM, Yamamoto KA, Salles TS, Campos R, de Meneses MD, Soares MR, Ferreira D Quercetin and quercetin 3- O -glycosides from Bauhinia longifolia Bong.

show anti-Mayaro virus activity. Parasit Vectors Dou J, Chen L, Xu G, Zhang L, Zhou H, Wang H, Su Z, Ke M, Guo Q, Zhou C Effects of baicalein on Sendai virus in vivo are linked to serum baicalin and its inhibition of hemagglutinin-neuraminidase. Arch Virol 5 — Eur J Pharm Sci — Ekor M The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety.

Front Pharmacol Evers DL, Chao CF, Wang X, Zhang Z, Huong SM, Huang ES Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action. Antiviral Res 68 3 — Falcone Ferreyra ML, Rius SP, Casati P Flavonoids: biosynthesis, biological functions, and biotechnological applications.

Front Plant Sci Fan W, Qian S, Qian P, Li X Antiviral activity of luteolin against Japanese encephalitis virus. Virus Res — Fatima K, Mathew S, Suhail M, Ali A, Damanhouri G, Azhar E, Qadri I Docking studies of Pakistani HCV NS3 helicase: a possible antiviral drug target.

PLoS One 9 9 :e Ferrer JL, Austin MB, Stewart C Jr, Noel JP Structure and function of enzymes involved in the biosynthesis of phenylpropanoids. Plant Physiol Biochem 46 3 — French CJ, Towers GN Inhibition of infectivity of potato virus X by flavonoids.

Phytochemistry — Ganesan S, Faris AN, Comstock AT, Wang Q, Nanua S, Hershenson MB, Sajjan US Quercetin inhibits rhinovirus replication in vitro and in vivo.

Antiviral Res 94 3 — Gao J, Xiao S, Liu X, Wang L, Ji Q, Mo D, Chen Y Inhibition of HSP70 reduces porcine reproductive and respiratory syndrome virus replication in vitro. BMC Microbiol Goldwasser J, Cohen PY, Lin W, Kitsberg D, Balaguer P, Polyak SJ, Chung RT, Yarmush ML, Nahmias Y Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism.

J Hepatol 55 5 — Gorlach S, Fichna J, Lewandowska U Polyphenols as mitochondria-targeted anticancer drugs. Cancer Lett 2 — Gravina HD, Tafuri NF, Silva Júnior A, Fietto JL, Oliveira TT, Diaz MA, Almeida MR In vitro assessment of the antiviral potential of trans-cinnamic acid, quercetin and morin against equid herpesvirus 1.

Res Vet Sci 91 3 :e—e Guo J, Xu X, Rasheed TK, Yoder A, Yu D, Liang H, Yi F, Hawley T, Jin T, Ling B, Wu Y Genistein interferes with SDF and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cells.

Retrovirology Guo Q, Zhao L, You Q, Yang Y, Gu H, Song G, Lu N, Xin J Anti-hepatitis B virus activity of wogonin in vitro and in vivo. Antiviral Res — Güttner J, Veckenstedt A, Heinecke H, Pusztai R Effect of quercetin on the course of mengo virus infection in immunodeficient and normal mice.

A histologic study. Acta Virol 26 3 — PubMed Google Scholar. Ha SY, Youn H, Song CS, Kang SC, Bae JJ, Kim HT, Lee KM, Eom TH, Kim IS, Kwak JH Antiviral effect of flavonol glycosides isolated from the leaf of Zanthoxylum piperitum on influenza virus.

J Microbiol 52 4 — Hakobyan A, Arabyan E, Avetisyan A, Abroyan L, Hakobyan L, Zakaryan H Apigenin inhibits African swine fever virus infection in vitro. Hassandarvish P, Rothan HA, Rezaei S, Yusof R, Abubakar S, Zandi K In silico study on baicalein and baicalin as inhibitors of dengue virus replication.

RSC Advances — He W, Li LX, Liao QJ, Liu CL, Chen XL Epigallocatechin gallate inhibits HBV DNA synthesis in a viral replication—inducible cell line. World J Gastroenterol 17 11 — Hollman PC, Bijsman MN, van Gameren Y, Cnossen EP, de Vries JH, Katan MB The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man.

Free Radic Res — Hung PY, Ho BC, Lee SY, Chang SY, Kao CL, Lee SS, Lee CN Houttuynia cordata targets the beginning stage of herpes simplex virus infection. PLoS One 10 2 :e Imanishi N, Tuji Y, Katada Y, Maruhashi M, Konosu S, Mantani N, Terasawa K, Ochiai H Additional inhibitory effect of tea extract on the growth of influenza A and B viruses in MDCK cells.

Microbiol Immunol 46 7 — Iranshahi M, Rezaee R, Parhiz H, Roohbakhsh A, Soltani F Protective effects of flavonoids against microbes and toxins: the cases of hesperidin and hesperetin.

Life Sci — Isaacs CE, Wen GY, Xu W, Jia JH, Rohan L, Corbo C, Di Maggio V, Jenkins EC Jr, Hillier S Epigallocatechin gallate inactivates clinical isolates of herpes simplex virus.

Antimicrob Agents Chemother 52 3 — Antimicrob Agents Chemother 55 12 — Jaganath IB, Jaganath IB, Mullen W, Edwards CA, Crozier A The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man.

Free Rad Res — Jeong HJ, Ryu YB, Park S-J, Kim JH, Kwon H-J, Kim JH, Park KH, Rho M-C, Lee WS Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities.

Bioorg Med Chem — Ji S, Li R, Wang Q, Miao WJ, Li ZW, Si LL, Qiao X, Yu SW, Zhou DM, Ye M Anti-H1N1 virus, cytotoxic and Nrf2 activation activities of chemical constituents from Scutellaria baicalensis. J Ethnopharmacol — Johari J, Kianmehr A, Mustafa MR, Abubakar S, Zandi K Antiviral activity of baicalein and quercetin against the Japanese encephalitis virus.

Int J Mol Sci 13 12 — Kang BK, Lee JS, Chon SK, Jeong SY, Yuk SH, Khang G, Lee HB, Cho SH Development of self-microemulsifying drug delivery systems SMEDDS for oral bioavailability enhancement of simvastatin in beagle dogs. Int J Pharm — Kaul TN, Middleton E, Ogra PL Antiviral effect of flavonoids on human viruses.

J Med Virol — Kawai K, Tsuno NH, Kitayama J, Okaji Y, Yazawa K, Asakage M, Hori N, Watanabe T, Takahashi K, Nagawa H Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp binding. J Allergy Clin Immunol 5 — Keum Y-S, Jeong Y-J Development of chemical inhibitors of the SARS coronavirus: viral helicase as a potential target.

Biochem Pharm — Khachatoorian R, Arumugaswami V, Raychaudhuri S, Yeh GK, Maloney EM, Wang J, Dasgupta A, French SW Divergent antiviral effects of bioflavonoids on the hepatitis C virus life cycle. Virology 2 — Khan N, Syed DN, Ahmad N, Mukhtar H Fisetin: a dietary antioxidant for health promotion.

Antioxid Redox Signal 19 2 — Antiviral Res 2 — Virol J Article PubMed PubMed Central Google Scholar. Kolokoltsov AA, Adhikary S, Garver J, Johnson L, Davey RA, Vela EM Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin.

Arch Virol 1 — Kumar S, Pandey AK Chemistry and biological activities of flavonoids: an overview. Sci World J Kumari A, Yadav SK, Pakade YB, Singh B, Yadav SC Development of biodegradable nanoparticles for delivery of quercetin.

Colloids Surf B Biointerfaces — Landete J Updated knowledge about polyphenols: functions, bioavailability, metabolism, and health. Crit Rev Food Sci Nutr — Lani R, Hassandarvish P, Chiam CW, Moghaddam E, Chu JJH, Rausalu K, Merits A, Higgs S, Vanlandingham D, Bakar SA Antiviral activity of silymarin against chikungunya virus.

Sci Rep Lani R, Hassandarvish P, Shu MH, Phoon WH, Chu JJ, Higgs S, Vanlandingham D, Abu Bakar S, Zandi K Antiviral activity of selected flavonoids against Chikungunya virus.

Lee HS, K-s Park, Lee C, Lee B, Kim D-E, Chong Y 7-O-Arylmethylgalangin as a novel scaffold for anti-HCV agents. Bioorg Med Chem Lett — Li BQ, Fu T, Dongyan Y, Mikovits JA, Ruscetti FW, Wang JM Flavonoid baicalin inhibits HIV-1 infection at the level of viral entry. Biochem Biophys Res Commun — Lin YJ, Chang YC, Hsiao NW, Hsieh JL, Wang CY, Kung SH, Tsai FJ, Lan YC, Lin CW Fisetin and rutin as 3C protease inhibitors of enterovirus A J Virol Methods 1—2 — Liu A-L, Wang H-D, Lee SM, Wang Y-T, Du G-H Structure-activity relationship of flavonoids as influenza virus neuraminidase inhibitors and their in vitro anti-viral activities.

Carcinogenesis 34 3 — Liu Z, Zhao J, Li W, Shen L, Huang S, Tang J, Duan J, Fang F, Huang Y, Chang H, Chen Z, Zhang R Computational screen and experimental validation of anti-influenza effects of quercetin and chlorogenic acid from traditional Chinese medicine.

FEBS J. Gabbay E et al Antioxidant therapy for chronic hepatitis C after failure of interferon: results of phase II randomized, double-blind placebo controlled clinical trial. Ganesan S et al Quercetin inhibits rhinovirus replication in vitro and in vivo. Antivir Res — Gauss A et al Intestinal cytomegalovirus infection in patients hospitalized for exacerbation of inflammatory bowel disease: a year tertiary referral center experience.

Eur J Gastroenterol Hepatol — Ghosh A, Desai A, Ravi V, Narayanappa G, Tyagi BK Chikungunya virus interacts with heat shock cognate 70 protein to facilitate its entry into mosquito cell line. Intervirology — Giri S et al Prevalence of hepatitis B virus and hepatitis C virus infection in patients with inflammatory bowel disease: a systematic review and meta-analysis.

Intest Res. Gonçalves A, Estevinho BN, Rocha F Methodologies for simulation of gastrointestinal digestion of different controlled delivery systems and further uptake of encapsulated bioactive compounds.

Trend Food Sci Technol — J Prev Alzheimers Dis — Gravina H et al In vitro assessment of the antiviral potential of trans-cinnamic acid, quercetin and morin against equid herpesvirus 1. Res Vet Sci e—e Gray-Rodriguez S et al Multisystem screening reveals SARS-CoV-2 in neurons of the myenteric plexus and in megakaryocytes.

J Pathol — J Hepatol — Guo W, Gong X, Li M Quercetin actions on lipid profiles in overweight and obese individuals: a systematic review and meta-analysis. Curr Pharm Des — Hagan M, Hayee BH, Rodriguez-Mateos A Poly phenols in inflammatory bowel disease and irritable bowel syndrome: a review.

Hanrahan TP, Lubel JS, Garg M Lessons from COVID, ACE2, and intestinal inflammation: could a virus trigger chronic intestinal inflammation? Clin Gastroenterol Hepatol Hazır-Konya H, Avkan-Oğuz V, Akpınar H, Sağol Ö, Sayıner A Investigation of cytomegalovirus in intestinal tissue in a country with high CMV seroprevalence.

Turk J Gastroenterol Hess LM, Michael D, Mytelka DS, Beyrer J, Liepa AM, Nicol S Chemotherapy treatment patterns, costs, and outcomes of patients with gastric cancer in the United States: a retrospective analysis of electronic medical record EMR and administrative claims data.

Gastric Cancer — Hickson LJ et al Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease. EBioMed — Hollman PC et al Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man.

FEBS Lett — Hommes DW, Sterringa G, van Deventer SJ, Tytgat GN, Weel J The pathogenicity of cytomegalovirus in inflammatory bowel disease: a systematic review and evidence-based recommendations for future research.

Hosseini A, Razavi BM, Banach M, Hosseinzadeh H Quercetin and metabolic syndrome: a review. Huang R-Y, Yu Y-L, Cheng W-C, OuYang C-N, Fu E, Chu C-L Immunosuppressive effect of quercetin on dendritic cell activation and function.

J Immunol — Huang Y-F, Bai C, He F, Xie Y, Zhou H Review on the potential action mechanisms of Chinese medicines in treating coronavirus disease COVID Pharm Res Hunt RH et al COVID and gastrointestinal disease: implications for the gastroenterologist. Digest Dis — Ilan Y et al A plant cell-expressed recombinant anti-TNF fusion protein is biologically active in the gut and alleviates immune-mediated hepatitis and colitis.

Immunobiol — Jannat K et al Nanotechnology applications of flavonoids for viral diseases. Pharmaceutics Jefremow A, Neurath MF All are equal, some are more equal: targeting IL 12 and 23 in IBD—a clinical perspective.

ImmunoTargets Ther Jena A, Mishra S, Singh AK, Sekar A, Sharma V Cytomegalovirus in ulcerative colitis: an evidence-based approach to diagnosis and treatment. Expert Rev Gastroenterol Hepatol — Jentzer A et al Cytomegalovirus and inflammatory bowel diseases IBD with a special focus on the link with ulcerative colitis UC.

Microorganisms Jia H et al Quercetin alleviates oxidative damage by activating nuclear factor erythroid 2-related factor 2 signaling in porcine enterocytes.

Nutrients Jimilihan S et al Study on the active components in the adjuvant treatment of novel coronavirus pneumonia COVID with Jinhua Qinggan granules based on network pharmacology and molecular docking. J Chin Med Mater — Google Scholar.

Jo S, Kim H, Kim S, Shin DH, Kim MS Characteristics of flavonoids as potent MERS-CoV 3C-like protease inhibitors. Chem Biol Drug Des — Jostins L et al Host—microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Nature — Ju S et al Dietary quercetin ameliorates experimental colitis in mouse by remodeling the function of colonic macrophages via a heme oxygenasedependent pathway.

Cell Cycle — Kaplan GG, Windsor JW The four epidemiological stages in the global evolution of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol — Kato S et al Substantial Epstein-Barr virus reactivation in a case of severe refractory ulcerative colitis: a possible role in exacerbation.

Clin J Gastroenterol — Kennedy NA et al Anti-SARS-CoV-2 antibody responses are attenuated in patients with IBD treated with infliximab. Khetsuriani N, LaMonte-Fowlkes A, Oberst S, Pallansch MA, Control CfD, Prevention Enterovirus surveillance—United States, — MMWR Surveill Summ — PubMed Google Scholar.

Kirchgesner J, Lemaitre M, Carrat F, Zureik M, Carbonnel F, Dray-Spira R Risk of serious and opportunistic infections associated with treatment of inflammatory bowel diseases. Gastroenterol Kishore J et al Infection with cytomegalovirus in patients with inflammatory bowel disease: prevalence, clinical significance and outcome.

J Med Microbiol — Diagnostics Kolho KL, Klemola P, Simonen-Tikka ML, Ollonen ML, Roivainen M Enteric viral pathogens in children with inflammatory bowel disease. J Med Virol — Kumari A, Bhawal S, Kapila S, Kapila R Strain-specific effects of probiotic Lactobacilli on mRNA expression of epigenetic modifiers in intestinal epithelial cells.

Arch Microbiol Lani R et al Antiviral activity of silymarin against chikungunya virus. Sci Rep — Lawlor G, Moss AC Cytomegalovirus in inflammatory bowel disease: pathogen or innocent bystander?

Leal T, Arroja B, Costa D, Ferreira C, Soares JB, Gonçalves R Colitis due to cytomegalovirus and herpes simplex type 2 as a complication of a first presentation of inflammatory bowel disease.

GE Port J Gastroenterol — Lee JW, Eun CS Inflammatory bowel disease in Korea: epidemiology and pathophysiology. Korean J Intern Med — Lee JM et al Clinical course of hepatitis B viral infection in patients undergoing anti-tumor necrosis factor α therapy for inflammatory bowel disease.

Gut Liver Li T, Li F, Liu X, Liu J, Li D a Synergistic anti-inflammatory effects of quercetin and catechin via inhibiting activation of TLR4—MyDmediated NF-κB and MAPK signaling pathways.

Li X et al b The status of Epstein-Barr virus infection in intestinal mucosa of Chinese patients with inflammatory bowel disease. Digest — Li Q, Zhou S, Wang Y, Cong J Changes of intestinal microbiota and microbiota-based treatments in IBD. Lin MV, Blonski W, Buchner AM, Reddy KR, Lichtenstein GR The influence of anti-TNF therapy on the course of chronic hepatitis C virus infection in patients with inflammatory bowel disease.

Digest Dis Sci — Liskova A, Samec M, Koklesova L, Samuel SM, Zhai K, Al-Ishaq RK Flavonoids against the SARS-CoV-2 induced inflammatory storm. Liu C-H et al Highly bioavailable silibinin nanoparticles inhibit HCV infection.

Loras C et al Liver dysfunction related to hepatitis B and C in patients with inflammatory bowel disease treated with immunosuppressive therapy.

Gut Losurdo G et al Chronic viral hepatitis in a cohort of inflammatory bowel disease patients from Southern Italy: a case-control study. Pathogens Luangsirithanya P, Treewaree S, Pongpaibul A, Pausawasdi N, Limsrivilai J Cytomegalovirus enterocolitis with subsequent diagnosis of coexisting new-onset inflammatory bowel disease: two case reports and review of the literature.

Lv Y-l et al Is cytomegalovirus infection related to inflammatory bowel disease, especially steroid-resistant inflammatory bowel disease? A meta-analysis. Infect Drug Resist Lyu YL, Zhou HF, Yang J, Wang FX, Sun F, Li JY Biological activities underlying the therapeutic effect of quercetin on inflammatory bowel disease.

Mediators Inflamm Maisuthisakul P, Pasuk S, Ritthiruangdej P Relationship between antioxidant properties and chemical composition of some Thai plants. J Food Compos Anal — Malaguarnera M et al Silybin-vitamin E-phospholipids complex reduces liver fibrosis in patients with chronic hepatitis C treated with pegylated interferon α and ribavirin.

Am J Transl Res CAS PubMed PubMed Central Google Scholar. Malaguarnera G et al Silybin supplementation during HCV therapy with pegylated interferon-α plus ribavirin reduces depression and anxiety and increases work ability.

BMC Psychiatr — Malik TA Inflammatory bowel disease: historical perspective, epidemiology, and risk factors. Surg Clin North Am — Mariño Z et al Intravenous silibinin monotherapy shows significant antiviral activity in HCV-infected patients in the peri-transplantation period.

Marongiu L, Venturelli S, Allgayer H Involvement of HHV-4 Epstein—Barr virus and HHV-5 cytomegalovirus in inflammatory bowel disease and colorectal cancer: a meta-analysis.

Cancers Masclee GM, Penders J, Pierik M, Wolffs P, Jonkers D Enteropathogenic viruses: triggers for exacerbation in IBD? A prospective cohort study using real-time quantitative polymerase chain reaction.

McClure J et al Silibinin inhibits HIV-1 infection by reducing cellular activation and proliferation. PLoS One 7:e McClure J, Margineantu DH, Sweet IR, Polyak SJ Inhibition of HIV by Legalon-SIL is independent of its effect on cellular metabolism.

Virology — McCurdy JD et al A model for identifying cytomegalovirus in patients with inflammatory bowel disease. Clin Gastroenterol Hepatol — Miri ST, Sotoodehnejadnematalahi F, Amiri MM, Pourshafie MR, Rohani M The impact of Lactobacillus and Bifidobacterium probiotic cocktail on modulation of gene expression of gap junctions dysregulated by intestinal pathogens.

Miura M et al Multicenter, cross-sectional, observational study on Epstein-Barr viral infection status and thiopurine use by age group in patients with inflammatory bowel disease in Japan EBISU study. J Gastroenterol — Molodecky NA, Kaplan GG Environmental risk factors for inflammatory bowel disease.

Gastroenterol Hepatol Monteleone G, Ardizzone S Are patients with inflammatory bowel disease at increased risk for Covid infection?

J Crohns Colitis — Mourad FH, Hashash JG, Kariyawasam VC, Leong RW Ulcerative colitis and cytomegalovirus infection: from A to Z. Münz C Latency and lytic replication in Epstein-Barr virus-associated oncogenesis.

Nat Rev Microbiol — Nair MP et al The flavonoid, quercetin, differentially regulates Th-1 IFNγ and Th-2 IL4 cytokine gene expression by normal peripheral blood mononuclear cells.

Biochim Biophys Acta — Neurath MF COVID and immunomodulation in IBD. Nikonov O, Chernykh E, Garber M, Nikonova EY Enteroviruses: classification, diseases they cause, and approaches to development of antiviral drugs.

Biochemistry mosc — Ninfali P, Antonelli A, Magnani M, Scarpa ES Antiviral properties of flavonoids and delivery strategies. Nutrients 12 9 Nissen LH et al Epstein-Barr virus in inflammatory bowel disease: the spectrum of intestinal lymphoproliferative disorders. Pathogens , 10, s Note: MDPI stays neutral with regard to jurisdictional claims in published.

Ouali SE, Achkar J-P Management of hospitalized patients with inflammatory bowel disease and CMV infection or Clostridium difficile infection. Management of inpatient inflammatory bowel disease. Springer, pp — Palit P, Mukhopadhyay A, Chattopadhyay D Phyto-pharmacological perspective of silymarin: a potential prophylactic or therapeutic agent for COVID, based on its promising immunomodulatory, anti-coagulant and anti-viral property.

Park S-K et al Prevention and management of viral hepatitis in inflammatory bowel disease: a clinical practice guideline by the Korean Association for the Study of Intestinal Diseases. Intest Res Patel K, Patel DK The beneficial role of rutin, a naturally occurring flavonoid in health promotion and disease prevention: a systematic review and update.

Bioactive food as dietary interventions for arthritis and related inflammatory diseases. Elsevier, — Patton K et al Epstein-barr virus associated colitis: another mimic of IBD? Pathol S Pavel FM et al a Highlighting the relevance of gut microbiota manipulation in inflammatory bowel disease.

Pavel FM et al b Highlighting the relevance of gut microbiota manipulation in inflammatory bowel disease. Diagnostics 11 6 Pavlidis C, Panoutsopoulos GI, Tiniakos D, Koutsounas S, Vlachogiannakos J, Zouboulis-Vafiadis I Serum leptin and ghrelin in chronic hepatitis C patients with steatosis.

Peng X et al Differences in HIV burden in the inflamed and non-inflamed colon from a person living with HIV and ulcerative colitis. J Virus Erad Piovani D, Danese S, Peyrin-Biroulet L, Nikolopoulos GK, Lytras T, Bonovas S Environmental risk factors for inflammatory bowel diseases: an umbrella review of meta-analyses.

Polyak SJ, Morishima C, Shuhart MC, Wang CC, Liu Y, Lee DYW Inhibition of T-cell inflammatory cytokines, hepatocyte NF-κB signaling, and HCV infection by standardized silymarin.

Gastroenterology — Powell RD, Warner NE, Levine RS, Kirsner JB Cytomegalic inclusion disease and ulcerative colitis: report of a case in a young adult. Am J Med — Puoti MG, Rybak A, Kiparissi F, Gaynor E, Borrelli O SARS-CoV-2 and the gastrointestinal tract in children. Front Pediatr Qaddir I, Rasool N, Hussain W, Mahmood S Computer-aided analysis of phytochemicals as potential dengue virus inhibitors based on molecular docking, ADMET and DFT studies.

J Vector Borne Dis Rastegarpanah M et al A randomized, double blinded, placebo-controlled clinical trial of silymarin in ulcerative colitis. Chin J Integr Med — Clin Cancer Res — Reddy HG, Schneider BJ, Tai AW Immune checkpoint inhibitor-associated colitis and hepatitis.

Clin Transl Gastroenterol 9 9 Rendina M et al Antiviral activity and safety profile of silibinin in HCV patients with advanced fibrosis after liver transplantation: a randomized clinical trial.

Transpl Int — Rivière A, Selak M, Lantin D, Leroy F, De Vuyst L Bifidobacteria and butyrate-producing colon bacteria: importance and strategies for their stimulation in the human gut.

Front Microbiol Rojas Á et al Effect of quercetin on hepatitis C virus life cycle: from viral to host targets. Sci Rep —9. Roy A et al Flavonoids a bioactive compound from medicinal plants and its therapeutic applications.

Ruiz F et al A single nucleotide polymorphism in the gene for GPR increases its surface expression on blood lymphocytes of patients with inflammatory bowel disease. Br J Pharmacol — Antivir Ther — Ryan JL et al Epstein-Barr virus infection is common in inflamed gastrointestinal mucosa.

Dig Dis Sci — Saeed M et al Silymarin: a potent hepatoprotective agent in poultry industry. Safarpour S et al Protective effect of kaempferol and its nanoparticles on 5-fluorouracil-induced cardiotoxicity in rats.

Salaritabar A et al Therapeutic potential of flavonoids in inflammatory bowel disease: a comprehensive review. Salloum N et al Epstein-Barr virus DNA modulates regulatory T-cell programming in addition to enhancing interleukinA production via Toll-like receptor 9.

PLoS One e Front Pharmacol Sheehan D, Moran C, Shanahan F The microbiota in inflammatory bowel disease. Shukla T, Singh S, Tandon P, McCurdy JD Corticosteroids and thiopurines, but not tumor necrosis factor antagonists, are associated with cytomegalovirus reactivation in inflammatory bowel disease.

J Clin Gastroenterol — Sokol H et al Fungal microbiota dysbiosis in IBD. Song J, Choi H Silymarin efficacy against influenza A virus replication. Phytomedicine — Song K, Wu D Shared decision-making in the management of patients with inflammatory bowel disease.

World J Gastroenterol — Spieker T, Herbst H Distribution and phenotype of Epstein-Barr virus-infected cells in inflammatory bowel disease. Am J Pathol — Statovci D, Aguilera M, MacSharry J, Melgar S The impact of western diet and nutrients on the microbiota and immune response at mucosal interfaces.

Front Immunol Su H-J et al Inflammatory bowel disease and its treatment in Global and Taiwanese status updates. J Formos Med Assoc — Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID patients.

J Med Virol. Mao L, Wang M, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Hu Y: Neurological manifestations of hospitalized patients with COVID in Wuhan, China: a retrospective case series study. Zhou P, Yang X-L, Wang X-G, Hu B, Zhang L, Zhang W, Si H-R, Zhu Y, Li B, Huang C-L.

A pneumonia outbreak associated with a new coronavirus of probable bat origin. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X.

Clinical features of patients infected with novel coronavirus in Wuhan, China. Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y. Epidemiological and clinical characteristics of 99 cases of novel coronavirus pneumonia in Wuhan, China: a descriptive study.

Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, Wang B, Xiang H, Cheng Z, Xiong Y. Clinical characteristics of hospitalized patients with novel coronavirus—infected pneumonia in Wuhan, China. Zahid A, Li B, Kombe JK, Jin T, Tao J.

Pharmacological inhibitors of the NLRP3 NLRP3 inflammasome. Front Immunol. Article PubMed PubMed Central CAS Google Scholar. Zhao C, Zhao W. NLRP3 NLRP3 inflammasome —a key player in antiviral responses. Panche A, Diwan A, Chandra S. Flavonoids: an overview. J Nutr Sci. Kelly GS.

Altern Med Rev. PubMed Google Scholar. Hollman PC, de Vries JH, van Leeuwen SD, Mengelers MJ, Katan MB.

Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am J Clin Nutr. Article CAS PubMed Google Scholar. Swanson KV, Deng M, Ting JP-Y. The NLRP3 NLRP3 inflammasome : molecular activation and regulation to therapeutics.

Nat Rev Immunol. Dinarello CA, Simon A, Van Der Meer JW. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev Drug Discov. Walle LV, Stowe IB, Šácha P, Lee BL, Demon D, Fossoul A, Van Hauwermeiren F, Saavedra PH, Šimon P, Šubrt V.

PLoS Biol. Article CAS Google Scholar. Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A.

A small-molecule inhibitor of the NLRP3 NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. Dempsey C, Araiz AR, Bryson K, Finucane O, Larkin C, Mills E, Robertson A, Cooper M, O'Neill L, Lynch M. Brain Behav Immun. van der Heijden T, Kritikou E, Venema W, van Duijn J, van Santbrink PJ, Slütter B, Foks AC, Bot I, Kuiper J.

NLRP3 NLRP3 inflammasome inhibition by MCC reduces atherosclerotic lesion development in apolipoprotein E—deficient mice—brief report. Arterioscler Thromb Vasc Biol. Article PubMed CAS Google Scholar.

Monnerat G, Alarcón ML, Vasconcellos LR, Hochman-Mendez C, Brasil G, Bassani RA, Casis O, Malan D, Travassos LH, Sepúlveda M. Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice. Nat Commun.

Mangan MS, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E. Targeting the NLRP3 NLRP3 inflammasome in inflammatory diseases. Mahmood DF, Abderrazak A, El Hadri K, Simmet T, Rouis M. The thioredoxin system as a therapeutic target in human health and disease.

Antioxid Redox Signal. Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to NLRP3 inflammasome activation.

Nat Immunol. Guo H, Callaway JB, Ting JP. NLRP3 inflammasome s: mechanism of action, role in disease, and therapeutics. Choe J-Y, Kim S-K. Quercetin and ascorbic acid suppress fructose-induced NLRP3 NLRP3 inflammasome activation by blocking intracellular shuttling of TXNIP in human macrophage cell lines.

Jiang W, Huang Y, Han N, He F, Li M, Bian Z, Liu J, Sun T, Zhu L. Quercetin suppresses NLRP3 NLRP3 inflammasome activation and attenuates histopathology in a rat model of spinal cord injury. Spinal Cord.

Lim H, Min DS, Park H, Kim HP. Flavonoids interfere with NLRP3 NLRP3 inflammasome activation. Toxicol Appl Pharmacol. Ding T, Wang S, Zhang X, Zai W, Fan J, Chen W, Bian Q, Luan J, Shen Y, Zhang Y.

Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 NLRP3 inflammasome. Wang W, Wang C, Ding XQ, Pan Y, Gu TT, Wang MX, Liu YL, Wang FM, Wang SJ, Kong LD. Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats.

Br J Pharmacol. Wu J, Xu X, Li Y, Kou J, Huang F, Liu B, Liu K. Quercetin, luteolin and epigallocatechin gallate alleviate TXNIP and NLRP3-mediated inflammation and apoptosis with regulation of AMPK in endothelial cells. Eur J Pharmacol. Zhang Q-Y, Pan Y, Wang R, Kang L-L, Xue Q-C, Wang X-N, Kong L-D.

J Nutr Biochem. Hu T, Lu XY, Shi JJ, Liu XQ, Chen QB, Wang Q, Chen YB, Zhang SJ. J Cell Mol Med. Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A. Inflammaging: a new immune—metabolic viewpoint for age-related diseases.

Nat Rev Endocrinol. Lanzillotta A, Sarnico I, Ingrassia R, Boroni F, Branca C, Benarese M, Faraco G, Blasi F, Chiarugi A, Spano P. The acetylation of RelA in Lys dictates the NF-κ B-dependent response in post-ischemic injury. Cell Death Dis. Park S, Shin J, Bae J, Han D, Park S-R, Shin J, Lee SK, Park H-W.

SIRT1 alleviates LPS-induced IL-1β production by suppressing NLRP3 NLRP3 inflammasome activation and ROS production in Trophoblasts. Article CAS PubMed Central Google Scholar. Gao R, Ma Z, Hu Y, Chen J, Shetty S, Fu J. Sirt1 restrains lung NLRP3 inflammasome activation in a murine model of sepsis.

Am J Phys Lung Cell Mol Phys. CAS Google Scholar. Zou P, Liu X, Li G, Wang Y. Resveratrol pretreatment attenuates traumatic brain injury in rats by suppressing NLRP3 NLRP3 inflammasome activation via SIRT1. Mol Med Rep.

CAS PubMed Google Scholar. Jiao P, Li W, Shen L, Li Y, Yu L, Liu Z. The protective effect of doxofylline against lipopolysaccharides LPS -induced activation of NLRP3 NLRP3 inflammasome is mediated by SIRT1 in human pulmonary bronchial epithelial cells.

Artif Cells Nanomed Biotechnol. Song H, Chen Q, Xie S, Huang J, Kang G. GDF prevents lipopolysaccharide-mediated acute lung injury via upregulating SIRT1. Biochem Biophys Res Commun. Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation. Gopalakrishnan V, Helmink BA, Spencer CN, Reuben A, Wargo JA.

The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy. Cancer Cell. Porras D, Nistal E, Martínez-Flórez S, Pisonero-Vaquero S, Olcoz JL, Jover R, González-Gallego J, García-Mediavilla MV, Sánchez-Campos S. Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation.

Free Radic Biol Med. Xue Y, Du M, Zhu M-J. Quercetin suppresses NLRP3 NLRP3 inflammasome activation in epithelial cells triggered by Escherichia coli O H7. Ahn H, Lee G-S. Isorhamnetin and hyperoside derived from water dropwort inhibits NLRP3 inflammasome activation.

Yang Y, Zhang X, Xu M, Wu X, Zhao F, Zhao C. Int Immunopharmacol. Hu Q-H, Zhang X, Pan Y, Li Y-C, Kong L-D. Allopurinol, quercetin and rutin ameliorate renal NLRP3 NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats. Biochem Pharmacol. Lee K-M, Kang JH, Yun M, Lee S-B.

Lara-Guzman OJ, Tabares-Guevara JH, Leon-Varela YM, Alvarez RM, Roldan M, Sierra JA, Londono-Londono JA, Ramirez-Pineda JR. Proatherogenic macrophage activities are targeted by the flavonoid quercetin. J Pharmacol Exp Ther. Ruiz-Miyazawa KW, Staurengo-Ferrari L, Mizokami SS, Domiciano TP, Vicentini FT, Camilios-Neto D, Pavanelli WR, Pinge-Filho P, Amaral FA, Teixeira MM.

Quercetin inhibits gout arthritis in mice: induction of an opioid-dependent regulation of NLRP3 inflammasome. Liu S, Tian L, Chai G, Wen B, Wang B. Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 NLRP3 inflammasome activation.

Food Funct. Xia S, Lan Q, Su S, Wang X, Xu W, Liu Z, Zhu Y, Wang Q, Lu L, Jiang S. The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin. Signal Transduct Target Ther. Nair A, James T: Computational screening of phytocompounds from Moringa oleifera leaf as potential inhibitors of SARS-CoV-2 Mpro.

Download references. The authors wish to acknowledge the support prepared by Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical, Sciences, Ahvaz, Iran.

ImmunologyToday, Universal Scientific Education and Research Network USERN , Tehran, Iran. Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

You can also search for this author in PubMed Google Scholar. Ali Saeedi-Boroujeni and Mohammad-Reza Mahmoudian-Sani designed the study and data collection and analysis. The authors read and approved the final manuscript.

Correspondence to Mohammad-Reza Mahmoudian-Sani. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Open Access This article is licensed under a Creative Commons Attribution 4.

Home » Neutraceuticals » Quedcetin » Antiviral Effects of Quercetin through Zinc Ionophore Activity. Quercetin and anti-viral properties is Mental stamina training increasingly well-known plant aand with potent Quercetin and anti-viral properties effects. The recent SARS-CoV-2 outbreak resulted in renewed research efforts focusing on its effects as a zinc-ionophore, increasing intracellular zinc concentrations and thus Quercetin working as an antiviral. In this article, we explore the relationship between zinc, ionophores, antivirals, and their potential use in modern society. Quercetin is a plant bioflavonoid found in many types of fruits and vegetables. Quercetin and anti-viral properties

Quercein polyphenol quercetin is one ane the Qiercetin flavonoids found Querctin many Chinese herbs, fruits, and vegetables. Common foods include blueberries, red onions, broccoli, cauliflower, kale, Quercetin and anti-viral properties many nuts.

Quercetin has Quercetin and anti-viral properties shown to offer strong antioxidant and anti-inflammatory benefits, along with anti-hypertensive, anticoagulant, and anti-hyperglycemic properties.

A previous study demonstrated that quercetin could help protect patients from dying anf severe complications associated with the Quercetin and anti-viral properties Chronic hyperglycemia prognosis A rpoperties however, Quercetin and anti-viral properties exact peoperties was Skinfold measurement techniques. In a study published in Viruses, propertjes investigated the effects Quercrtin quercetin as an Quercetni agent.

The impact of Post-workout recovery supplements vary. They can poperties seasonal outbreaks and, as angi-viral are now seeing with COVID, a worldwide pandemic that Carbohydrate-rich foods for athletes public Quercdtin as well as the economy.

Breakfast for stronger muscles have been several other highly propertids infections anti-virap as the H1N1 swine flu, Propwrties avian influenza, and H7N9 influenza virus, which can lead to pgoperties respiratory distress syndrome, anti-vral Quercetin and anti-viral properties, and anti-iral.

Due to Quercetin and anti-viral properties lack of drugs Qurcetin treat Increase stamina naturally hese infections, natural compounds are a major area of anti-viral an discovery. The Quercetin and anti-viral properties cycle antiviral the influenza virus consists of pro;erties attachment, entry, replication, Quercetin and anti-viral properties, and Quercetin and anti-viral properties.

This study demonstrated that quercetin can inhibit the entry of an influenza virus in the early stage of infection, measuring the inhibition in a cell infection model. This is the initial step of the viral replication cycle. In addition, the research team noted that this inhibitory effect was increased when the virus was pre-incubated with quercetin.

It is also important to note that, being an antioxidant and having anti-inflammatory properties, quercetin helps reduce the expression of pro-inflammatory cytokines and lung inflammation in mice.

As a result, quercetin may be an inexpensive yet effective natural polyphenol, providing support during influenza infections. It may also be considered in combination with other therapeutics and drugs, which could support their anti-viral effect while helping reduce drug dosage and side effects.

Dosage range for quercetin supplementation is often between mg to mg. Other compounds with potential anti-viral properties include vitamins A, C, and D, zinc, monolaurin, melatonin, resveratrol, and geranylgeraniol.

Vitamin C specifically has been shown to enhance the absorption of quercetin and increase plasma levels. By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS. Source: Wu Wenjiao, Li Richan, et al.

Quercetin as an Antiviral Agent Inhibits Influenza A. Virus IAV Entry. Designs for Health has been dedicated to being the most trusted source for superior quality, science-based nutritional products for nearly three decades. The blogs we publish here cover a range of topics, including new and original approaches to diet and healthcare, analyses of the latest cutting-edge research, deep-dives into specific nutrients, botanicals, nutraceuticals and more, all fully referenced for those who want to dig deeper into the primary literature.

Science Update. Study demonstrates antiviral effect of quercetin by inhibiting virus entry. March 27, - facebook twitter linkedin.

By Michael Jurgelewicz, DC, DACBN, DCBCN, CNS Source: Wu Wenjiao, Li Richan, et al. Quercetin as an Antiviral Agent Inhibits Influenza A Virus IAV Entry. More Science Update. Load more. Search Designs for Health Search form Search. LATEST POSTS. Micronutrients to Promote Endothelial Integrity and Healthy Inflammatory Status.

New Review Investigates the Efficacy of Different Probiotics in IBS. The Role of the Oral Microbiome on Nitric Oxide Production and Healthy Blood Pressure.

Tags Vitamin D. Gut Microbiome. Recent Review. Healthy Aging. Gut Health. Antioxidative Status. Cardiovascular Health. Blood sugar. Mood Health. Fish oil. Bone Health. Vitamin E.

: Quercetin and anti-viral properties

Human Verification The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Nat Commun. Although numerous flavonoids have demonstrated anti-inflammatory and antiviral effects, the current study offered insights on the efficacy of quercetin a flavanol and silymarin also flavo-lignane. Front Immunol. In addition to this potential antiviral property, these compounds also have antioxidant properties that can help limit the damage of the severe form of COVID [ 51 ].
Publication types Quercetin Carbohydrate-based Supplements classified as a flavonoid compound propperties was anri-viral known to have Quercetin and anti-viral properties, antibacterial, antioxidant, and anti-inflammatory activities. Quercetinn, the issue still properries Quercetin and anti-viral properties to low solubility and low stability of quercetin in the lipophilic media of a membrane owing to the presence of hydroxyl groups [ 20 ]. Quercetin is a plant bioflavonoid found in many types of fruits and vegetables. Silymarin bioactive compound is obtained from Prolerties marianum seeds with high anti-inflammatory activity. Dayem AA, Choi HY, Kim YB, Cho S-G Antiviral effect of methylated flavonol isorhamnetin against influenza.
REVIEW article Antioxidant therapy as a potential approach to severe influenza-associated complications. HSPs oversee the proper configuration of protein structures and this mechanism may be hijacked by viruses and used for viral protein replication. Lani R et al Antiviral activity of silymarin against chikungunya virus. Plant Signal Behav 5 4 — Article CAS PubMed PubMed Central Google Scholar Manvar D, Mishra M, Kumar S, Pandey VN Identification and evaluation of antihepatitis C virus phytochemicals from Eclipta alba. PLoS One 6 11 :e Types of cytosolic sensors out of the NLRP family include Absent in melanoma 2 AIM2 and IFI16, which contain a DNA sensor domain and an N-terminal pyrin domain that can form inflammasome. However, QQ can be recycled into quercetin by electron donors like NADH or ascorbate, or form together, with glutathione either 6-glutathionyl-quercetin or 8-glutathionyl-quercetin GSQs ,
Flavonoids: promising natural compounds against viral infections | Archives of Virology Zou H, Ye H, Kamaraj R, Zhang Snti-viral, Zhang J, Pavek P A review on ati-viral activities and synergistic effect of quercetin with Quercetin and anti-viral properties molecule wnti-viral. Kolho KL, Klemola Qnti-viral, Simonen-Tikka ML, Ollonen ML, Roivainen M Enteric viral pathogens in children with inflammatory bowel disease. CAN Article CAS PubMed Google Scholar DebRoy S et al Hepatitis C virus dynamics and cellular gene expression in uPA-SCID chimeric mice with humanized livers during intravenous silibinin monotherapy. Güttner J, Veckenstedt A, Heinecke H, Pusztai R. Moreover, concomitant RV infection in mice with COPD phenotype induces a further elevation in T cells, neutrophils, and macrophages.
Protective mechanism of quercetin and its derivatives in viral-induced respiratory illnesses Zhang W, Qiao H, Lv Y, Wang J, Chen X, Hou Y, Tan R, Li E Apigenin inhibits enterovirus infection by disrupting viral RNA association with trans-acting factors. In our previous review, quercetin showed promising molecular effects against novel severe acute respiratory syndrome coronavirus-2 SARS-CoV-2 through specific mechanisms by blocking the interaction of spike protein S-protein on angiotensin-converting enzyme 2 ACE2 receptor, effects on 3C-like protease 3CL pro , papain-like protease PL pro , and RNA-dependent RNA polymerase RdRp [ 6 ]. A histologic study. Correspondence to Hovakim Zakaryan. Quercetin is classified as a flavonoid compound and was previously known to have antiviral, antibacterial, antioxidant, and anti-inflammatory activities.


Stop Quercetin Supplements (New Study)

Author: Taugrel

4 thoughts on “Quercetin and anti-viral properties

  1. Ich meine, dass Sie den Fehler zulassen. Ich kann die Position verteidigen. Schreiben Sie mir in PM, wir werden besprechen.

Leave a comment

Yours email will be published. Important fields a marked *

Design by