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Oxidative stress and cancer

Oxidative stress and cancer

Nat Cell Oxidative stress and cancer. Clin Microbiol Rev — Mylonis I, Kourti Oxixative, Samiotaki M, Panayotou An, Simos G. Huo YY et al PTEN deletion leads to deregulation of antioxidants and increased oxidative damage in mouse embryonic fibroblasts. Int Rev Immunol. The differentiation of regDCs and myeloid-derived suppressor cells MDSC by TAM promotes the immunosuppressive TME [, ].


Dr. Marcus Cooke explains oxidative stress

Oxidative stress and cancer -

Free radicals: relationship to human diseases and potential therapeutic applications. Int J Biochem Cell Biol. Baird L, Yamamoto M. The molecular mechanisms regulating the KEAP1-NRF2 pathway. Mol Cell Biol.

Deshmukh P, Unni S, Krishnappa G, Padmanabhan B. The Keap1—Nrf2 pathway: promising therapeutic target to counteract ROS-mediated damage in cancers and neurodegenerative diseases. Biophys Rev.

Klaunig JE. Oxidative stress and cancer. Curr Pharm Des. Klaunig JE, Wang Z. Oxidative stress in carcinogenesis. Curr Opin Toxicol. di Meo S, Reed TT, Venditti P, Victor VM.

Role of ROS and RNS sources in physiological and pathological conditions. Oxid Med Cell Longev. Navarro-Yepes J, Burns M, Anandhan A, Khalimonchuk O, del Razo LM, Quintanilla-Vega B, Pappa A, Panayiotidis MI, Franco R. Oxidative stress, redox signaling, and autophagy: cell death versus survival.

Antioxid Redox Signal. Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med.

Zelickson BR, Ballinger SW, Dell'Italia LJ, Zhang J, Darley-Usmar VM. Reactive Oxygen and Nitrogen Species: Interactions with Mitochondria and Pathophysiology. William J. Lennarz, M. Daniel Lane, Editors. Encyclopedia of Biological Chemistry.

Academic Press; Fu Y, Chung F-L. Oxidative stress and hepatocarcinogenesis. Hepatoma Res. Hayes JD, Dinkova-Kostova AT, Tew KD. Oxidative stress in cancer. Cancer Cell. Rhee SG, Woo HA, Kil IS, Bae SH. Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides.

J Biol Chem. Mititelu RR, Padureanu R, Bacanoiu M, Padureanu V, Docea AO, Calina D, Barbulescu AL, Buga AM. Inflammatory and oxidative stress markers-Mirror tools in rheumatoid arthritis.

Zhang X, Hu M, Yang Y, Xu H. Organellar TRP channels. Nat Struct Mol Biol. Saretzki G. Telomerase, mitochondria and oxidative stress. Exp Gerontol. Loreto Palacio P, Godoy JR, Aktas O, Hanschmann EM. Changing perspectives from oxidative stress to redox signaling-extracellular redox control in translational medicine.

Antioxidants Basel. Rudrapal M, Khairnar SJ, Khan J, Dukhyil AB, Ansari MA, Alomary MN, Alshabrmi FM, Palai S, Deb PK, Devi R. Dietary polyphenols and their role in oxidative stress-induced human diseases: insights into protective effects, antioxidant potentials and mechanism s of action.

Front Pharmacol. Chaitanya M, Ramanunny AK, Babu MR, Gulati M, Vishwas S, Singh TG, Chellappan DK, Adams J, Dua K, Singh SK. Journey of Rosmarinic acid as biomedicine to Nano-biomedicine for treating Cancer: current strategies and future perspectives.

Garzoli S, Alarcón-Zapata P, Seitimova G, Alarcón-Zapata B, Martorell M, Sharopov F, Fokou PVT, Dize D, Yamthe LRT, Les F, Cásedas G, López V, Iriti M, Rad JS, Gürer ES, Calina D, Pezzani R, Vitalini S. Natural essential oils as a new therapeutic tool in colorectal cancer.

Cancer Cell Int. Article PubMed PubMed Central Google Scholar. Moloney JN, Cotter TG. ROS signalling in the biology of cancer. Elsevier; Google Scholar. Reczek CR, Chandel NS. The two faces of reactive oxygen species in cancer. Annu Rev Cancer Biol.

Sosa V, Moliné T, Somoza R, Paciucci R, Kondoh H, Lleonart ME. Oxidative stress and cancer: an overview. Ageing Res Rev. Ribatti D, Tamma R, Annese T. Epithelial-mesenchymal transition in cancer: a historical overview. Transl Oncol. Mego M, Reuben J, Mani SA.

Epithelial-mesenchymal transition EMT and cancer stem cells CSCs : the traveling metastasis. In: Liquid biopsies in solid tumors. Springer; Natale G, Bocci G. Discovery and development of tumor angiogenesis assays.

Methods Mol Biol. Pagano K, Carminati L, Tomaselli S, Molinari H, Taraboletti G, Ragona L. Lugano R, Ramachandran M, Dimberg A. Tumor angiogenesis: causes, consequences, challenges and opportunities.

Cell Mol Life Sci. Aggarwal V, Tuli HS, Varol A, Thakral F, Yerer MB, Sak K, Varol M, Jain A, Khan M, Sethi G.

Role of reactive oxygen species in cancer progression: molecular mechanisms and recent advancements. Son Y, Cheong YK, Kim NH, Chung HT, Kang DG, Pae HO. Mitogen-activated protein kinases and reactive oxygen species: how can ROS activate MAPK pathways? J Signal Transduct. Koundouros N, Poulogiannis G.

Front Oncol. Ngo V, Duennwald ML. Nrf2 and oxidative stress: A general overview of mechanisms and implications in human disease. Hu Q, Bian Q, Rong D, Wang L, Song J, Huang H-S, Zeng J, Mei J, Wang P-Y. Front Bioeng Biotechnol. Lin L, Wu Q, Lu F, Lei J, Zhou Y, Liu Y, Zhu N, Yu Y, Ning Z, She T, Hu M.

Nrf2 signaling pathway: current status and potential therapeutic targetable role in human cancers. Chen Y, Chen M, Deng K. Int J Oncol. Shi T, Dansen TB. Reactive oxygen species induced p53 activation: DNA damage, redox signaling, or both?

Xing F, Hu Q, Qin Y, Xu J, Zhang B, Yu X, Wang W. The relationship of redox with hallmarks of Cancer: the importance of homeostasis and context. Vurusaner B, Poli G, Basaga H.

Tumor suppressor genes and ROS: complex networks of interactions. Shaw P, Kumar N, Sahun M, Smits E, Bogaerts A, Privat-Maldonado A.

Modulating the antioxidant response for better oxidative stress-inducing therapies: how to take advantage of two sides of the same medal?

Pisoschi AM, Pop A, Iordache F, Stanca L, Predoi G, Serban AI. Oxidative stress mitigation by antioxidants - an overview on their chemistry and influences on health status. Eur J Med Chem. Bieging KT, Mello SS, Attardi LD.

Unravelling mechanisms of pmediated tumour suppression. Nat Rev Cancer. Liang Y, Liu J, Feng Z. The regulation of cellular metabolism by tumor suppressor p Cell Biosci. Srinivas US, Tan BW, Vellayappan BA, Jeyasekharan AD.

ROS and the DNA damage response in cancer. Redox Biol. Maxwell KN, Cheng HH, Powers J, Gulati R, Ledet EM, Morrison C, LE A, Hausler R, Stopfer J, Hyman S. Inherited TP53 variants and risk of prostate Cancer.

Eur Urol. Morris LG, Chan TA. Therapeutic targeting of tumor suppressor genes. Puzio-Kuter AM, Castillo-Martin M, Kinkade CW, Wang X, Shen TH, Matos T, Shen MM, Cordon-Cardo C, Abate-Shen C.

Inactivation of p53 and Pten promotes invasive bladder cancer. Genes Dev. Wang B. BRCA1 tumor suppressor network: focusing on its tail. Bae I, Fan S, Meng Q, Rih JK, Kim HJ, Kang HJ, Xu J, Goldberg ID, Jaiswal AK, Rosen EM.

BRCA1 induces antioxidant gene expression and resistance to oxidative stress. Cancer Res. Sundararajan S, Ahmed A, Goodman OB Jr. The relevance of BRCA genetics to prostate cancer pathogenesis and treatment.

Clin Adv Hematol Oncol. PubMed Google Scholar. Yi YW, Kang HJ, Bae I. BRCA1 and oxidative stress. Fridlich R, Annamalai D, Roy R, Bernheim G, Powell SN. BRCA1 and BRCA2 protect against oxidative DNA damage converted into double-strand breaks during DNA replication.

DNA Repair. Mersch J, Jackson MA, Park M, Nebgen D, Peterson SK, Singletary C, Arun BK, Litton JK. Cancers associated with BRCA 1 and BRCA 2 mutations other than breast and ovarian.

Menegon S, Columbano A, Giordano S. The dual roles of NRF2 in cancer. Trends Mol Med. de La Vega MR, Chapman E, Zhang DD. NRF2 and the hallmarks of cancer. Article PubMed Central Google Scholar. Choi B-H, Kwak M-K.

Shadows of NRF2 in cancer: resistance to chemotherapy. Jung B-J, Yoo H-S, Shin S, Park Y-J, Jeon S-M. Dysregulation of NRF2 in cancer: from molecular mechanisms to therapeutic opportunities. Biomol Ther. Article CAS Google Scholar. Indovina P, Pentimalli F, Casini N, Vocca I, Giordano A.

RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy. Macleod KF. The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system. di Fiore R, D'Anneo A, Tesoriere G, Vento R.

RB1 in cancer: different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis. J Cell Physiol. Article PubMed Google Scholar. Villeneuve NF, Sun Z, Chen W, Zhang DD. Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels. Book Google Scholar.

He S, Liu M, Zhang W, Xu N, Zhu H. Over expression of pactivated kinase 7 associates with lymph node metastasis in esophageal squamous cell cancers. Cancer Biomarkers. Jing Z, You-Hong J, Wei Z. Expression of p21 and p15 in gastric cancer patients. Aceto GM, Catalano T, Curia MC.

Molecular aspects of colorectal adenomas: the interplay among microenvironment, oxidative stress, and predisposition. BioMed Res Int. Qin R-F, Zhang J, Huo H-R, Yuan Z-J, Xue J-D. MiR mediated APC regulation contributes to pancreatic cancer cell proliferation. World J Gastroenterol.

Donkena KV, Young CY, Tindall DJ. Oxidative stress and DNA methylation in prostate cancer. Obstet Gynecol Int.

Fang Z, Xiong Y, Li J, Liu L, Zhang W, Zhang C, Wan J. APC gene deletions in gastric adenocarcinomas in a Chinese population: a correlation with tumour progression. Clin Transl Oncol. Davee T, Coronel E, Papafragkakis C, Thaiudom S, Lanke G, Chakinala RC, González GMN, Bhutani MS, Ross WA, Weston BR.

Pancreatic cancer screening in high-risk individuals with germline genetic mutations. Gastrointest Endosc. Aghabozorgi AS, Bahreyni A, Soleimani A, Bahrami A, Khazaei M, Ferns GA, Avan A, Hassanian SM.

Role of adenomatous polyposis coli APC gene mutations in the pathogenesis of colorectal cancer; current status and perspectives.

Hankey W, Frankel WL, Groden J. Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting. Cancer Metastasis Rev. Narayan S, Sharma R.

Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis. Life Sci. Katerji M, Filippova M, Duerksen-Hughes P. Approaches and methods to measure oxidative stress in clinical samples: research applications in the Cancer field.

Chiorcea-Paquim A-M. Milkovic L, Zarkovic N, Marusic Z, Zarkovic K, Jaganjac M. The 4-Hydroxynonenal-protein adducts and their biological relevance: are some proteins preferred targets? Liu Y, Al-Adra DP, Lan R, Jung G, Li H, Yeh MM, Liu YZ.

RNA sequencing analysis of hepatocellular carcinoma identified oxidative phosphorylation as a major pathologic feature. Hepatol Commun. Jiang C, Qian M, Gocho Y, Yang W, Du G, Shen S, Yang JJ, Zhang H.

Blood Adv. Pimkova K, Jassinskaja M, Munita R, Ciesla M, Guzzi N, Cao Thi Ngoc P, Vajrychova M, Johansson E, Bellodi C, Hansson J. Quantitative analysis of redox proteome reveals oxidation-sensitive protein thiols acting in fundamental processes of developmental hematopoiesis.

Higgins L, Gerdes H, Cutillas PR. Principles of phosphoproteomics and applications in cancer research. Biochem J. Serafimov K, Aydin Y, Lämmerhofer M. Quantitative analysis of the glutathione pathway cellular metabolites by targeted liquid chromatography - tandem mass spectrometry.

J Sep Sci. Wang Z, Ma P, Wang Y, Hou B, Zhou C, Tian H, Li B, Shui G, Yang X, Qiang G, Yin C, Du G. Untargeted metabolomics and transcriptomics identified glutathione metabolism disturbance and PCS and TMAO as potential biomarkers for ER stress in lung.

Sci Rep. Greenwood HE, Witney TH. Latest advances in imaging oxidative stress in Cancer. J Nucl Med. Ghasemitarei M, Ghorbi T, Yusupov M, Zhang Y, Zhao T, Shali P, Bogaerts A. has uncovered the importance of ROS in regulating multiple signaling pathways.

Cancer cells can resist therapy by increasing their antioxidant defense system to cope with high levels of ROS. The authors summarized the molecular mechanisms behind this resistance, including drug efflux, DNA repair, stemness maintenance and tumor microenvironment alteration.

Zhuo et al. They demonstrated that the oncogene eIF3a plays a crucial role in cancer development and responses to various therapies, especially those known to promote oxidative stress.

Using a proteomics approach, they systematically elucidated its relationship with oxidative stress and found that it is involved in lipid peroxidation, which affects the response of cancer cells to cytotoxic antitumor drugs.

These findings suggest that eIF3a may serve as a bridge between oxidative stress and cancer, providing insights into cancer development and therapy from cellular processes, molecular signaling pathways, metabolism, and immune responses.

All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Cheung, E. The role of ROS in tumour development and progression. Cancer 22 5 , — PubMed Abstract CrossRef Full Text Google Scholar. Coradduzza, D. Ferroptosis and senescence: A systematic review.

Luo, M. Antioxidant therapy in cancer: Rationale and progress. Antioxidants 11 6 , WHO-IARC World health organization — international agency research on cancer. Google Scholar.

Citation: Liao Q, Wang Z and Cadena SMSC Editorial: Targeting oxidative stress in cancer: what is new in the prevention, diagnostic, treatment and prognostic strategies?. doi: Li, S. Wang and J. Fang, Chem. This article is licensed under a Creative Commons Attribution-NonCommercial 3.

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Thank Oxicative for visiting nature. You are cacer a browser version with limited support Oxidative stress and cancer CSS. Cancerr obtain the shress experience, Low-calorie diet tips for busy people recommend you use a more up to date browser or turn off compatibility mode in Internet Oxidative stress and cancer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Reactive oxygen species ROS constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. It is now well accepted that moderate levels of ROS are required for several cellular functions, including gene expression. The production of ROS is elevated in tumor cells as a consequence of increased metabolic rate, gene mutation and relative hypoxia, and excess ROS are quenched by increased antioxidant enzymatic and nonenzymatic pathways in the same cells. Oxidative stress and cancer Cell Oidative and Signaling volume Oxidative stress and cancerArticle number: 7 Cite this Oxidative stress and cancer. Metrics anv. Cancer Oxidativf a significant global public Diabetic nephropathy clinical trials concern, Oxidativw increasing incidence and mortality rates worldwide. Oxidative stress, anr by the production of reactive Oxidarive species ROS within cells, plays a critical role in the development of cancer by affecting genomic stability and signaling pathways within the cellular microenvironment. Elevated levels of ROS disrupt cellular homeostasis and contribute to the loss of normal cellular functions, which are associated with the initiation and progression of various types of cancer. In this review, we have focused on elucidating the downstream signaling pathways that are influenced by oxidative stress and contribute to carcinogenesis.

Author: Fenrilabar

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