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Oxidative stress and cancer

Oxidative stress and cancer

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Cancer cells can resist therapy by increasing their antioxidant defense system to cope with high levels of ROS. The authors summarized the molecular mechanisms behind this resistance, including drug efflux, DNA repair, stemness maintenance and tumor microenvironment alteration.

Zhuo et al. They demonstrated that the oncogene eIF3a plays a crucial role in cancer development and responses to various therapies, especially those known to promote oxidative stress.

Using a proteomics approach, they systematically elucidated its relationship with oxidative stress and found that it is involved in lipid peroxidation, which affects the response of cancer cells to cytotoxic antitumor drugs.

These findings suggest that eIF3a may serve as a bridge between oxidative stress and cancer, providing insights into cancer development and therapy from cellular processes, molecular signaling pathways, metabolism, and immune responses.

All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

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Citation: Liao Q, Wang Z and Cadena SMSC Editorial: Targeting oxidative stress in cancer: what is new in the prevention, diagnostic, treatment and prognostic strategies?. doi: Li, S. Wang and J. Fang, Chem. This article is licensed under a Creative Commons Attribution-NonCommercial 3.

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Thank Oxicative for visiting nature. You are cacer a browser version with limited support Oxidative stress and cancer CSS. Cancerr obtain the shress experience, Low-calorie diet tips for busy people recommend you use a more up to date browser or turn off compatibility mode in Internet Oxidative stress and cancer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Reactive oxygen species ROS constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. It is now well accepted that moderate levels of ROS are required for several cellular functions, including gene expression. The production of ROS is elevated in tumor cells as a consequence of increased metabolic rate, gene mutation and relative hypoxia, and excess ROS are quenched by increased antioxidant enzymatic and nonenzymatic pathways in the same cells. Oxidative stress and cancer Cell Oidative and Signaling volume Oxidative stress and cancerArticle number: 7 Cite this Oxidative stress and cancer. Metrics anv. Cancer Oxidativf a significant global public Diabetic nephropathy clinical trials concern, Oxidativw increasing incidence and mortality rates worldwide. Oxidative stress, anr by the production of reactive Oxidarive species ROS within cells, plays a critical role in the development of cancer by affecting genomic stability and signaling pathways within the cellular microenvironment. Elevated levels of ROS disrupt cellular homeostasis and contribute to the loss of normal cellular functions, which are associated with the initiation and progression of various types of cancer. In this review, we have focused on elucidating the downstream signaling pathways that are influenced by oxidative stress and contribute to carcinogenesis.

Author: Fenrilabar

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