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Resveratrol and inflammation

Resveratrol and inflammation

Resveratrol: a double-edged sword Resvsratrol health benefits. The results of Crowell et al. By Kerri-Ann Jennings, MS, RD on July 3,


Resveratrol Benefits \u0026 Side Effects [Best Supplements \u0026 Best Foods]

Resveratrol and inflammation -

The skins and seeds of grapes and berries contain resveratrol, making red wine high in this compound. Research shows promising health benefits, but more is needed regarding how much supplementation you need.

But beyond being a healthful part of red wine and other foods, resveratrol has health-boosting potential in its own right. In fact, resveratrol supplements have been linked to many exciting health benefits, including protecting brain function and lowering blood pressure 1 , 2 , 3 , 4.

This article explains what you need to know about resveratrol, including seven of its main potential health benefits. Resveratrol is a plant compound that acts like an antioxidant. The top food sources include red wine , grapes, some berries and peanuts 5 , 6.

This compound tends to be concentrated mostly in the skins and seeds of grapes and berries. These parts of the grape are included in the fermentation of red wine, hence its particularly high concentration of resveratrol 5 , 7.

However, much of the research on resveratrol has been done in animals and test tubes using high amounts of the compound 5 , 8.

Of the limited research in humans, most has focused on supplemental forms of the compound, in concentrations higher than those you could get through food 5. Resveratrol is an antioxidant-like compound found in red wine, berries and peanuts.

Much of the human research has used supplements that contain high levels of resveratrol. Because of its antioxidant properties, resveratrol could be a promising supplement for lowering blood pressure 9. A review concluded that high doses may help reduce the pressure exerted on artery walls when the heart beats 3.

That type of pressure is called systolic blood pressure, and appears as the upper number in blood pressure readings. Systolic blood pressure typically goes up with age, as arteries stiffen.

Resveratrol may accomplish this blood-pressure-lowering effect by helping to produce more nitric oxide, which causes blood vessels to relax 10 , However, the authors of that study say more research is needed before specific recommendations can be made about the best dose of resveratrol to maximize blood pressure benefits.

Resveratrol supplements may help lower blood pressure by increasing the production of nitric oxide. Several studies in animals have suggested that resveratrol supplements may change blood fats in a healthy way 12 , A study fed mice a high-protein, high-polyunsaturated fat diet and also gave them resveratrol supplements.

Resveratrol seems to influence cholesterol levels by reducing the effect of an enzyme that controls cholesterol production LDL oxidation contributes to plaque buildup in artery walls 9 , In one study, participants were given grape extract that had been boosted with extra resveratrol.

After six months of treatment, their LDL had gone down by 4. Resveratrol supplements may benefit blood fats in animals.

As an antioxidant, they may also decrease LDL cholesterol odixation. It works to achieve this in the same way as calorie restriction, which has shown promise in lengthening lifespans by changing how genes express themselves 18 , Resveratrol supplements have lengthened lifespan in animal studies.

Several studies have suggested that drinking red wine can help slow down age-related cognitive decline 21 , 22 , 23 , Additionally, the compound may set off a chain of events that protects brain cells from damage While this research is intriguing, scientists still have questions about how well the human body is able to make use of supplemental resveratrol, which limits its immediate use as a supplement to protect the brain 1 , 2.

A potent antioxidant and anti-inflammatory compound, resveratrol shows promise in protecting brain cells from damage. These benefits include increasing insulin sensitivity and preventing complications from diabetes 26 , 27 , 28 , One explanation for how resveratrol works is that it may stop a certain enzyme from turning glucose into sorbitol, a sugar alcohol.

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Medical News Today. Health Conditions Health Products Discover Tools Connect. What to know about resveratrol. Medically reviewed by Katherine Marengo LDN, R. What it is Benefits Side effects How to consume Dosage Summary Resveratrol is a plant compound derived from red grapes that has antioxidant-like properties.

What is resveratrol? Side effects and risks. How to consume. How we reviewed this article: Sources. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations.

We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.

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Medically reviewed by Karen Richardson Gill, MD, FAAP. How do free radicals affect the body? Resveratrol has many potential health benefits due to its antioxidant and anti-inflammatory properties. Resveratrol has been studied extensively for its potential benefits for heart health, including its ability to lower blood pressure and improve cholesterol levels.

Several studies show that resveratrol's antioxidant effects can help reduce systolic and diastolic blood pressure in people with hypertension high blood pressure and may protect against stroke.

Other research suggests that resveratrol may improve the function of the endothelium—the inner lining of blood vessels—helping reduce vascular oxidative stress and stiffness in arteries, which helps promote healthy blood flow and protects against heart disease.

Resveratrol has also been shown to improve blood lipid cholesterol levels, reducing total cholesterol and triglycerides a type of fat. High blood lipid fat levels are associated with increased heart disease and stroke risk. Resveratrol has been shown to decrease low-density lipoprotein LDL , often called "bad" cholesterol, which may help protect against heart disease.

Resveratrol may boost cognitive function and protect against certain neurodegenerative disorders , such as Alzheimer's disease. Resveratrol has potent antioxidant activity that helps protect neurons brain cells against the effects of harmful free radicals—chemicals associated with the development of Alzheimer's disease, Parkinson's disease, and Huntingdon's.

Resveratrol has also been shown to improve the function of the hippocampus—the part of the brain responsible for memory, learning, and spatial navigation. Research shows that resveratrol's anti-inflammatory properties may protect cognitive function in older adults, helping maintain memory and cognitive function as you age.

One study found that resveratrol reduced the accumulation of amyloid-beta plaques in the brain—a hallmark of Alzheimer's disease.

The study found that a mg daily dose of resveratrol for 52 weeks significantly reduced amyloid-beta levels in the cerebrospinal fluid of individuals with mild to moderate Alzheimer's disease, which suggests that resveratrol may help slow disease progression.

Research investigating the effects of resveratrol on metabolic function suggests that it may benefit metabolic health by helping regulate blood sugar levels and reducing insulin sensitivity, which may lower the risk of type 2 diabetes and other metabolic conditions.

Resveratrol may help manage type 2 diabetes, according to some research. One study found that resveratrol supplementation improved insulin sensitivity and reduced blood sugar glucose levels in individuals with type 2 diabetes. Another study found that resveratrol lowers oxidative stress in people with diabetes, which may help protect against diabetes-related complications like heart disease.

Additional studies found that resveratrol supplementation of mg daily for 12 weeks reduced body weight, waist circumference, and markers of inflammation in individuals with metabolic syndrome a group of conditions that can increase your risk of stroke, heart disease, and type 2 diabetes.

Study participants had significantly improved insulin sensitivity, reduced blood pressure, and improved metabolism of lipids a type of fat. Resveratrol has powerful antioxidant and anti-inflammatory properties, which may help promote joint health and reduce joint pain and damage in people with certain types of arthritis.

Research suggests that resveratrol may be an effective complementary therapy and help reduce joint pain in people with osteoarthritis. In one study, a mg daily dose of resveratrol supplementation significantly reduced joint pain in people with mild to moderate knee osteoarthritis when paired with standard treatment.

In another study, resveratrol effectively relieved joint inflammation and damage in people with rheumatoid arthritis RA. It was thought to protect against certain complications of RA, such as periodontitis gum disease and interstitial pneumonia.

Resveratrol has been investigated for its potential use in preventing cancer and as an adjuvant additional therapy for cancer treatments. Test tube and animal studies show that resveratrol may have anticancer properties that may help prevent or fight certain types of cancer, including breast, colon, gastric, pancreas, prostate, ovarian, and endometrial cancers.

Research shows that resveratrol may:. In addition to the health benefits listed above, resveratrol may have other benefits. More research is needed to determine if resveratrol offers the following benefits:. Resveratrol is considered safe and well-tolerated when taken in recommended doses, but like any supplement, it may cause side effects in some people.

Side effects are more common at high doses and may include:. While resveratrol is generally safe, especially when consumed in foods, not everyone should take resveratrol supplements. People with the following conditions should avoid resveratrol supplements:. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your needs.

The appropriate dosage of resveratrol varies, depending on the specific supplement product and intended use. Studies show that doses up to 5 grams 5, mg daily are safe, but side effects are more common with doses above 2.

Some research suggests that taking smaller doses is better than taking one large dose, as resveratrol is metabolized quickly. Speak with a healthcare provider before you take resveratrol supplements. They can help you determine the best supplement and dosage based on your needs.

There is no established upper limit or recommended intake for resveratrol, and there have been no reports of toxicity or overdose in humans from dietary or supplemental sources.

However, studies in rodents have shown that extremely high doses of resveratrol can lead to kidney and liver damage. If you take very high doses of resveratrol, you may experience side effects or adverse events such as:.

Seek medical attention if you suspect you have taken too much resveratrol. Resveratrol can interact with certain medications, herbs, and supplements, potentially causing adverse effects and changing how these medicines work in your body.

Resveratrol may interact with the following:. Supplements and herbs that have similar effects or potential interactions with resveratrol include:. Many supplements come with recommended storage suggestions on the product label, though not all do.

Resveratrol supplements should be stored:. If your supplement has expired or shows signs of deterioration, such as changes in color or capsules clumping together, it should be discarded. If you are unsure how to store a particular resveratrol supplement, ask for guidance from your healthcare provider or contact the manufacturer directly.

Similar supplements to resveratrol include:. Like resveratrol, each of these supplements has antioxidant and anti-inflammatory properties that may benefit cardiovascular health, joint health, and cognitive function.

Many of these compounds are being studied for their potential anti-cancer effects. Taking these supplements alongside resveratrol is generally safe, but it is important to be mindful of possible interactions or side effects.

Resveratrol is found in several dietary sources, including red wine, grapes, berries, and peanuts. The amounts of resveratrol in these sources vary, and research shows that it is not possible to absorb the recommended therapeutic doses of resveratrol through diet alone.

Therefore, supplements may be a more reliable way to ensure you get the therapeutic benefits of resveratrol. Resveratrol is a natural compound found in various plant-based foods, particularly in the skins of red grapes and berries.

Common food sources of resveratrol include:. Resveratrol is available in capsule, tablet, powder, liquid, and gummy forms. Capsules and tablets are the most commonly used and can be taken with water. Liquids may be a good option if you have difficulty swallowing pills or prefer to add resveratrol to your food or drinks.

There is no evidence to suggest that one form of resveratrol is superior to others in terms of efficacy. The supplement's potency can vary, depending on the amount of resveratrol in the supplement and manufacturer.

When shopping for resveratrol supplements, look for a high-quality product from a reputable brand. Resveratrol is a naturally occurring polyphenol compound in grape skins, berries, and peanuts. It is also available as a dietary supplement. Packed with antioxidant, anti-inflammatory, and anticancer compounds, resveratrol may benefit cardiovascular, joint, and metabolic health and improve cognitive function.

Phytochemicals present in Stay cool and energized with hydrating fluids have shown inflajmation prospects ane the treatment and inflaammation of a vast array of human diseases. Resveratrol is a stilbene-type aromatic phytoalexin predominantly Fresh and viable seeds in grapes, peanuts, Resveratrol and inflammation, turmeric, and other food products. Resveratrol Resveratrol and inflammation been reported Resveratrol and inflammation infammation several Resvetatrol activities including inflammwtion and anti-inflammatory activities in vitro and in experimental animal models, as well as in humans. Anticancer activity of this compound is mainly due to induction of apoptosis via several pathways, as well as alteration of gene expressions, all leading to a decrease in tumor initiation, promotion, and progression. Resveratrol exhibits anti-inflammatory activity through modulation of enzymes and pathways that produce mediators of inflammation and also induction of programmed cell death in activated immune cells. Resveratrol has been shown to produce no adverse effects, even when consumed at high concentrations. Hence, resveratrol possesses good potential to be used as an adjunctive or alternative therapy for cancer and inflammatory diseases. Resveratrol and inflammation The purpose of inflammztion study was Resverarrol explore the regulatory effect inflammatkon resveratrol Resveratrol and inflammation on tips for regulating glucose levels LPS -induced inflammation and its influence on Resvetatrol microorganisms and serum Football diet plan in murine models during the development of inflammatoin to explore inflamnation novel method for the regulation Resverarol inflammation. Mice were randomly assigned to three groups: control CONLPS, and RES—LPS. The results showed that RES mitigated the inflammatory damage to the intes-tines and liver induced by LPS. Compared with the LPS group, RES treatment decreased the levels of TNF-α, IL-6, IFN-γ, myeloperoxidase, and alanine aminotransferase in the liver. Moreover, RES treatment alleviated the negative effects of LPS on intestinal microbes by reducing, for instance, the relative abundance of Bacteroidetes and Alistipes, and increasing the relative abundance of Lactobacillus. These results suggest that RES has great potential for preventing in-flammation. Inflammation is a fundamental aspect of gastrointestinal function.

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