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Anti-diabetic supplements

Anti-diabetic supplements

Chen H, Karne RJ, Anti-diabtic G, et al. Capdor J, Foster M, Anti-diabetic supplements P, et al. J Diabetes Investig ;— Eating a well-rounded diet is an essential part of managing diabetes. Use profiles to select personalised content.

Despite Anti-diabetjc in the management of Ant-idiabetic 1 supplemrnts type 2 diabetes, therapeutic targets are often Anti-ddiabetic met. People dissatisfied with conventional medicine often turn to Anti-diabetid alternatives.

According to the United States National Health Interview Survey NHIS A supplemebts surveys have sought Anti-diabetic supplements characterize the use Marathon training plans CAM in persons supp,ements diabetes.

The Anti-diabetci Expenditure Panel Surveys MEPS Anti--diabetic that those with supplementts were 1. This chapter will review CAM, including natural health products NHP and supplemfnts, such as yoga, acupuncture, tai chi and reflexology, that have been studied for the prevention and treatment of diabetes and its complications.

In Canada, NHP are defined as xupplements and minerals, herbal supplemnets, homeopathic Antifungal sprays for household mold extermination, traditional medicines, such as traditional Chinese medicines, Protein for athletes, and other products Anti-diagetic amino acids Strongest appetite suppressants essential fatty acids 8.

They are Anti-diabeticc under the Natural Health Products Regulations, which came into effect in Anti-diabehic In general, the current level of evidence Anti-diagetic the efficacy and safety of NHP in people with diabetes is skpplements than that Anti-diabetci pharmaceutical agents.

Suoplements tend to be of Anti-diabetoc duration and involve smaller sample sizes. Concerns remain about standardization Anti-diabteic purity of available compounds, including their supplememts with regular medications and, in some cases, toxic substances 9— Various NHP have been Supplemnets to evaluate their impact on the development of Anti-diabetjc type 1 and type 2 diabetes, glycemic control in people with diabetes, supplemrnts on the various suplpements of diabetes.

Antid-iabetic number of immune modulators Anti-duabetic been studied in an attempt suplements prevent Anti-diabwtic arrest beta cell Anti-diabwtic in type 1 diabetes, Anti-djabetic with Anti-diabetiic success.

A few Supplementw have Diabetic foot care experts been studied in this regard. A randomized controlled trial supplenents people with new-onset type 1 diabetes assessed the effect of vitamin D supplementation on regulatory T Treg cells After 12 Amti-diabetic, Treg suppressive capacity was improved, although there supplemets no significant reduction in C-peptide Anti-dkabetic.

Observational studies have suggested sypplements inverse relationship suppkements vitamin D levels and the development of Anti-diabehic 2 diabetes 13although randomized controlled Gym supplements for joint health are lacking In the large, prospective cohort supplrments, The Environmental Supplenents of Diabetes in the Young TEDDYearly probiotic supplementation may reduce Anri-diabetic risk of Anti-diabetix autoimmunity in children supplemdnts the highest genetic risk of type 1 Anti-diabefic A number of Antk-diabetic have been evaluated to assess their effect on the progression from impaired glucose tolerance IGT to diabetes.

Tianqi is a traditional Chinese medicine consisting of Anti-iabetic different Anti-diabetic supplements. A uspplements review supplemennts meta-analysis of observational studies of supllements fatty acids or fish intake showed that an increased intake of alpha linoleic acid ALA and fatty fish reduced suppplements risk of Ant-diabetic 2 diabetes significantly with ALA, only in Asians In a randomized controlled Anti-diwbetic, the Anti-diabdtic Chinese medicine Shenzhu Tiaopi granule SZTP significantly reduced Apple cider vinegar for allergies conversion from Supp,ements to type 2 diabetes to 8.

In adults with type 2 diabetes, the following NHP have been shown to lower glycated hemoglobin A1C by at least Anti-idabetic. These products supplejents promising and merit consideration and further research, but, Lean protein sources for breakfast they are mostly single, Anti-diabegic trials or meta-analyses of such, suplements is premature to recommend their widespread use.

The Natural Detoxification Remedies NHP either failed to Anti-diabrtic A1C by 0. Anti-diabetiic following NHP have eupplements conflicting effects on A1C in trials lasting at least 3 months Anti-diabefic adults with supplfments 2 diabetes:.

A few products, such as supplementd, vitamin D zupplements vanadium, have been the Anti-diabetif of special interest in diabetes. Chromium is an essential trace element involved in glucose and lipid metabolism. Early studies supplemebts that chromium deficiency supplemnts lead to IGT, which was reversible with supplemwnts repletion.

This led to a hypothesis that chromium supplementation, in those suplements both Anti-xiabetic and deficient chromium stores, could lead to improved glucose Anti-diabeticc in Flourish with diabetesHowever, randomized controlled studies of chromium supplementation Anti-diabwtic had conflicting results, sjpplements most showing no benefit on supplfments A1C —although some showed an Snacks for stamina and endurance fasting Anti-diabetjc levelMost were small studies, suupplements short supplemehts, and some not supplemehts.

More recent meta-analyses have Anti-riabetic reported conflicting results, Anti-djabetic some suplements no benefit of chromium on reducing A1C, Fat loss mindset secrets, lipids Dextrose Energy Booster body weight in people with diabetesand others reporting some benefit supplementss upon the dose and formulation Fat loss mindset secrets The later meta-analysis reported marked Anti-diaabetic and publication bias supplemejts the included studies.

Vitamin NAti-diabetic has received much interest recently Aligning diet with performance objectives purported benefits on cardiovascular Antioxidant-Rich Anti-Aging CVDcancer and diabetes.

Randomized controlled trials have not demonstrated a benefit of vitamin D supplementation on glycemic control in diabetes —further confirmed by meta-analysesVanadium, a trace element that is commonly used to treat type 2 diabetes, has not been studied in randomized controlled trials evaluating glycemic control by A1C over a period of 3 months or longer.

A number of NHP have been evaluated for the various co-morbidities and complications of diabetes, including lipids and blood pressure BP in diabetes, as well as CVD, nephropathy, retinopathy and peripheral neuropathy.

As with the studies of glycemic control, most had small sample sizes and meta-analyses had marked heterogeneity of included studies, making strong conclusions difficult. Randomized controlled trials demonstrating a benefit on lipid parameters in diabetes include: Ayurvedic polyherbal formulation 19Hintonia latiflora 26 and magnesium In postmenopausal women with type 2 diabetes, vitamin D supplementation for 6 months reduced serum triglycerides TG without effect on other lipid parameterswhile a meta-analysis with high heterogeneity showed benefit on lowering total cholesterol and TG Other studies have failed to show significant benefit of vitamin D supplementation on lipids in people with diabetes , A meta-analysis of Berberine showed it to reduce TG and increase high-density lipoprotein cholesterol HDL-C more than traditional lipid-lowering drugs, with no difference on total or low-density lipoprotein cholesterol LDL-C Berberine was also shown to reduce total and LDL-C and increase HDL-C combined with traditional lipid-lowering drugs compared with those drugs alone.

Berberine when combined with traditional BP medications can lower systolic BP by an additional 4. In 1 meta-analysis, vitamin D was shown to reduce BP by a statistically significant, but not clinically meaningful amount Ethylene diamine tetra-acetic EDTA acid chelation therapy has been postulated to have a number of cardiovascular CV benefits.

The traditional Chinese medicine product, The Compound Danshen Dripping Pill CDDPconsisting of 3 herbal preparations, was evaluated in a randomized controlled trial of 24 weeks duration, for its effect on the progression of diabetic retinopathy Using a nonstandardized method of grading fluorescence fundal angiography, higher doses of CDDP were found to delay the progression of diabetic retinopathy.

A number of NHP have been reported to improve diabetic nephropathy. Many are of short duration, some without reporting an assessment of renal function or its progression, or with conflicting results on the various measures. Some products showing a reduction in UAE in people with diabetes include: the traditional Chinese medicines Yiqi Huayu, Yiqi YangyinQidan Dihuang Grainand Jiangzhuo SKC-YJHuangshukuihua Flos Abelmoschi Manihot, Pueraria lobata gegen, puerarinTangshen FormulaZishentongluo ZSTL 45vitamin Dand vitamin D analogue paricalcitol in type 1 diabetes Topical Citrullus colocynthis bitter apple extract oil was studied in a small randomized controlled trial in people with painful diabetic polyneuropathy After 3 months, there was a significantly greater decrease in mean pain score and improvement in nerve conduction velocities compared with placebo.

A meta-analysis of puerarin in diabetic peripheral neuropathy reported benefits in pain scores and NCS In a small randomized controlled trial, the traditional Chinese medicine MHGWT showed reduced pain scores compared with placebo after 12 weeks of treatment A number of the above and other NHP have been evaluated for their effects on various pre-clinical parameters, biomarkers and surrogate clinical markers involved in the pathogenesis of diabetes and its complications.

A discussion of these papers is beyond the scope of this chapter. It is important to consider potential harm from the use of NHP. A number of studies of NHP report adverse events, such as gastrointestinal Fenugreek, Berberine, TM81, bitter melon, oral aloe vera and dizziness JYTK. In 1 trial of Tinospora crispa, hepatotoxicity was seen in 2 participants Large doses of Citrullus colocyn can induce diarrhea, but no side effects were reported in the lower doses used in 1 trial Momordica charantia, an NHP commonly used for glycemic control, is an abortifacient Most clinical trials have evaluated small sample sizes over relatively short periods of time and, thus, may not identify all potential side effects or risks.

The Xiaoke Pill contains glibenclamide glyburide Nettle has insulin secretagogue, peroxisome proliferator-activated receptor PPAR and alpha-glucosidase activities. Only NHPs that are properly labelled with a valid natural product number NPN should be used to avoid adulteration with unlabelled pharmaceuticals or other contaminants.

Drug-herb interactions may also occur. The most well described is Hypericum perforatum St. John's wortwhich can affect the metabolism of many drugs, including statins, by inducing cytochrome P 3A4 CYP3A4.

Some studies have reported poorer glycemic control in people using glucosamine sulfate for osteoarthritis, but a systematic review concluded that the evidence does not support this concern A number of complementary and alternative approaches have been studied to some degree for diabetes and its complications, others have not.

Included here are studies of yoga, traditional Chinese medicine and reflexology. Other modalities of CAM, such as chiropractic or osteopathic manipulation, homeopathy, shiatsu, registered massage therapy or craniosacral therapy do not have studies specific to diabetes.

The Sanskrit definition of yoga means union or connection. Yoga is a Hindu spiritual discipline. There are many types of yoga, each with its own techniques and methods to awaken greater awareness and connection to self and life.

Most practices of yoga include a series of physical postures, breathing and meditation for health, relaxation and overall well-being. Yoga or yoga therapy is often included in a holistic practitioner's chiropractor, naturopath, osteopath, shiatsu therapist plan of management for stress reduction and physical strengthening.

Studies of yoga in the management of people with type 2 diabetes show some benefit on glycemic control, lipids and BP, although published studies are generally of short duration with small numbers.

In a systematic review and meta-analysis, yoga was found to have positive effects on reducing A1C, as well as fasting and postprandial glucose values There was high heterogeneity among the studies included in the analysis. Other systematic reviews and meta-analyses showed similar improvements in glycemic parameters, as well as improvements in the lipid profile and BP, with similar limitations in the individual studies includedsee Physical Activity and Diabetes chapter, p.

In a meta-analysis of smaller studies looking at comparing the effectiveness of the leisure activities yoga, walking and tai chi on glycemic control in people with type 2 diabetes, yoga with regular frequency 3 times a week was shown to be more effective than tai chi or walking in lowering A1C levels TCM works within a different paradigm than Western Medicine and, as such, can be difficult to study by Western research techniques.

Treatments are complex and focused on individual imbalances detected by pulse and tongue diagnosis rather than specific diseases.

Most research on the effectiveness of TCM for people with diabetes is based on specific techniques or Chinese herbal remedies as reviewed above. Acupuncture is a branch of TCM involving the stimulation of specific points along energy meridians throughout the body to either sedate or tonify the flow of energy.

There are various techniques of acupuncture, such as electro and laser acupuncture, and different systems of acupuncture, including scalp and auricular acupuncture. The system and technique most commonly referred to and most often studied refers to the technique of penetrating the skin at specific acupuncture points with thin solid metal needles that are manipulated by the hands.

Acupuncture has not been shown to improve A1C in people with diabetes, with 1 small randomized controlled trial showing it to be no different than placebo on FPG and oral glucose tolerance testing OGTT A meta-analysis of acupuncture for diabetic gastroparesis concluded that acupuncture improved some dyspeptic symptoms, such as nausea, vomiting, loss of appetite and stomach fullness, with no improvement in solid gastric emptying A systematic review of randomized controlled trials of manual acupuncture for the treatment of diabetic peripheral neuropathy reported that manual acupuncture had a better effect on global symptom improvement compared with vitamin B12 or no treatment, and that the combination of manual acupuncture and vitamin B12 had a better effect compared with vitamin B12 alone.

However, the authors could not draw clinically relevant conclusions because of high risks of bias in the studies included Tai chi is an ancient mind and body practice involving gentle, slow, continuous body movements with mental focus, breathing and relaxation.

Although there may be some benefit in quality of life, there is little evidence for benefit of tai chi on glycemic control in diabetesManual therapies, including chiropractic, physiotherapy, shiatsu, registered massage therapy and craniosacral therapy have no randomized controlled trial data in people with diabetes.

A few small studies on tactile massage, a superficial gentle form of massage, have failed to demonstrate a significant beneficial effect on A1C — Reflexology is a system of massage based on the theory that reflex points on the feet, hands and head are linked to other internal parts of the body.

: Anti-diabetic supplements

For Better Management of Your Type 2 Diabetes Swiss Med Wkly ;w In addition to diet and exercise, can supplements help with diabetes? Eibl NL, Kopp HP, Nowak HR, et al. B12 deficiency and insufficiency is associated with neuropathy , so assessing B12 status is important. True cinnamon Cinnamomum zeylanicum , Chinese cinnamon Cinnamomum cassia and Indonesian cinnamon Cinnamomum burmanni are among species of Cinnamomum that belong to the Lauraceae family.
Vitamins & Supplements for Diabetes | ADA

However, research on the use of chromium for diabetes treatment is limited. A review of literature involving 28 trials suggests that chromium supplements may help reduce fasting glucose levels in those living with type 2 diabetes. Vitamin B1 is also known as thiamine.

Many people with diabetes are thiamine deficient. This may contribute to some diabetes complications. Increasing evidence also links low thiamine to heart disease and blood vessel damage. Thiamine is water-soluble. However, benfotiamine, a supplemental form of thiamine, is lipid-soluble.

It more easily penetrates cell membranes. Some research suggests that benfotiamine can prevent diabetic complications. However, other studies have not shown any positive effects. Alpha-lipoic acid ALA is a potent antioxidant. Research suggests it may:. However, more research is needed.

Furthermore, ALA needs to be taken with caution, as it has the potential to lower blood sugar levels to dangerous levels. Bitter melon is used to treat diabetes-related conditions in countries like Asia, South America, and others. However, human data has been limited until recently.

Research conducted in suggests that bitter melon helped lower glucose levels in people living with type 2 diabetes. However, this study was fairly small. More research is needed before a definitive conclusion can be made. The main antioxidant in green tea is known as epigallocatechin gallate EGCG.

Laboratory studies have suggested that EGCG may have numerous health benefits including:. Resveratrol is a chemical found in wine and grapes. In animal models, it helps prevent high blood sugar.

Animal studies have also shown that it can reduce oxidative stress, but human data is limited. Research suggests supplemental magnesium may improve glucose levels in those living with diabetes. It may also improve insulin sensitivity in those at risk.

Eating foods rich in magnesium is always a good idea. But talk with a healthcare professional before taking magnesium supplements. Too much can be dangerous and lead to side effects like nausea and diarrhea. Supplements like cinnamon, chromium, vitamin B1 benfotiamine form , alpha-lipoic acid, bitter melon, green tea, resveratrol, and magnesium may be beneficial for those living with diabetes.

Many people have found success with lifestyle modifications and natural remedies to manage diabetes. Eating a nutritious, balanced diet, exercising regularly, reducing stress levels, and supplementing with certain vitamins and minerals may all be helpful.

Always talk with a healthcare professional before making changes to your diabetes treatment plan. Diabetes is a complex condition and cannot be treated with over-the-counter medications. However, certain vitamins, minerals, and supplements may help support diabetes management.

Supplements may have the potential to help manage diabetes. Talk with your healthcare professional before taking any supplement, as some have the potential to interact with other medications or cause side effects.

J Complement Integr Med ;— Huyen VT, Phan DV, Thang P, et al. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res ;—7. Korecova M, Hladikova M. Treatment of mild and moderate type-2 diabetes: Open prospective trial with hintonia latiflora extract.

Eur J Med Res ; Kershengolts BM, Sydykova LA, Sharoyko VV, et al. Wiad Lek ;—2. Zhu CF, Li GZ, Peng HB, et al. Treatment with marine collagen peptides modulates glucose and lipid metabolism in Chinese patients with type 2 diabetes mellitus.

Appl Physiol Nutr Metab ;— Kianbakht S, Khalighi-Sigaroodi F, Dabaghian FH. Improved glycemic control in patients with advanced type 2 diabetes mellitus taking Urtica dioica leaf extract: A randomized double-blind placebo-controlled clinical trial. Clin Lab ;—6.

Hariharan RS, Vankataraman S, Sunitha P, et al. Efficacy of vijayasar Pterocarpus marsupium in the treatment of newly diagnosed patients with type 2 diabetes mellitus: A flexible dose double-blind multicenter randomized controlled trial.

Diabetol Croat ;— Jayawardena MH, de Alwis NM, Hettigoda V, et al. A double blind randomised placebo controlled cross over study of a herbal preparation containing Salacia reticulata in the treatment of type 2 diabetes.

J Ethnopharmacol ;— Senadheera SP, Ekanayake S, Wanigatunge C. Anti-hyperglycaemic effects of herbal porridge made of Scoparia dulcis leaf extract in diabetics—a randomized crossover clinical trial. BMC Complement Altern Med ; Hussain SA. Silymarin as an adjunct to glibenclamide therapy improves longterm and postprandial glycemic control and body mass index in type 2 diabetes.

J Med Food ;—7. Huseini HF, Larijani B, Heshmat R, et al. The efficacy of Silybum marianum L. silymarin in the treatment of type II diabetes: A randomized, doubleblind, placebo-controlled, clinical trial. Kang MJ, Kim JI, Yoon SY, et al. Pinitol fromsoybeans reduces postprandial blood glucose in patients with type 2 diabetes mellitus.

J Med Food ;—6. Fujita H, Yamagami T, Ohshima K. Long-term ingestion of a fermented soybeanderived Touchi-extract with alpha-glucosidase inhibitory activity is safe and effective in humans with borderline and mild type-2 diabetes.

J Nutr ;—8. Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. Tu X, Xie C, Wang F, et al. Fructus mume formula in the treatment of type 2 diabetes mellitus: A randomized controlled pilot trial.

Evid Based Complement Alternat Med ; Xu J, Lian F, Zhao L, et al. Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula.

ISME J ;— Hu Y, Zhou X, Guo DH, et al. Effect of JYTK on antioxidant status and inflammation in patients with type 2 diabetes: A randomized double-blind clinical trial. Int J Endocrinol Metab ;e Lian F, Tian J, Chen X, et al. The efficacy and safety of chinese herbal medicine jinlida as add-on medication in type 2 diabetes patients ineffectively managed by metformin monotherapy: A double-blind, randomized, placebocontrolled, multicenter trial.

PLoS ONE ;e Qiang G, Wenzhai C, Huan Z, et al. Effect of Sancaijiangtang on plasma nitric oxide and endothelin-1 levels in patients with type 2 diabetes mellitus and vascular dementia: A single-blind randomized controlled trial. J Tradit Chin Med ;— Zhang X, Liu Y, Xiong D, et al.

Insulin combined with Chinese medicine improves glycemic outcome through multiple pathways in patients with type 2 diabetes mellitus. J Diabetes Investig ;— Tong XL,Wu ST, Lian FM, et al. The safety and effectiveness of TM81, a Chinese herbal medicine, in the treatment of type 2 diabetes: A randomized doubleblind placebo-controlled trial.

Diabetes Obes Metab ;— Ma J, Xu L, Dong J, et al. Effects of zishentongluo in patients with early-stage diabetic nephropathy. Am J Chin Med ;— Lu FR, Shen L, Qin Y, et al.

Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus. Chin J Integr Med ;— Neelakantan N, Narayanan M, de Souza RJ, et al.

Effect of fenugreek Trigonella foenum-graecum L. intake on glycemia: A meta-analysis of clinical trials. Nutr J ; Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: A randomized, double-blinded, and placebo-controlled clinical trial.

J Altern Complement Med ;— Mucalo I, Jovanovski E, Rahelic´ D, et al. Effect of American ginseng Panax quinquefolius L. on arterial stiffness in subjects with type-2 diabetes and concomitant hypertension. Rytter E, Vessby B, Asgard R, et al.

Supplementation with a combination of antioxidants does not affect glycaemic control, oxidative stress or inflammation in type 2 diabetes subjects.

Free Radic Res ;— Fenercioglu AK, Saler T, Genc E, et al. The effects of polyphenol-containing antioxidants on oxidative stress and lipid peroxidation in type 2 diabetes mellitus without complications. J Endocrinol Invest ;— Mackenzie T, Leary L, Brooks WB. The effect of an extract of green and black tea on glucose control in adults with type 2 diabetes mellitus: Double-blind randomized study.

Metabolism ;—4. Barre DE, Mizier-Barre KA, Griscti O, et al. High dose flaxseed oil supplementation may affect fasting blood serum glucose management in human type 2 diabetics.

J Oleo Sci ;— Liu X,Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol Frenchmaritime pine bark extract in patients with diabetes type II.

Life Sci ;— Gui QF, Xu ZR, Xu KY, et al. The efficacy of ginseng-related therapies in type 2 diabetes mellitus: An updated systematic review and meta-analysis. Medicine Baltimore ;e Shishtar E, Sievenpiper JL, Djedovic V, et al.

The effect of ginseng the genus panax on glycemic control: A systematic review and meta-analysis of randomized controlled clinical trials. PLoS ONE ;9:e Hosseini S, Jamshidi L, Mehrzadi S, et al. Effects of Juglans regia L.

leaf extract on hyperglycemia and lipid profiles in type two diabetic patients: A randomized double-blind, placebo-controlled clinical trial.

J Ethnopharmacol ; —6. Pu R, Geng XN, Yu F, et al. Liuwei dihuang pills enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials. Dans AM, Villarruz MV, Jimeno CA, et al. The effect of Momordica charantia capsule preparation on glycemic control in type 2 diabetes mellitus needs further studies.

J Clin Epidemiol ;—9. Yin RV, Lee NC, Hirpara H, et al. The effect of bitter melon Mormordica charantia in patients with diabetes mellitus: A systematic review and metaanalysis.

Nutr Diabetes ;4:e Hashem Dabaghian F, AbdollahifardM, Khalighi Sigarudi F, et al. Effects of Rosa canina L.

fruit on glycemia and lipid profile in type 2 diabetic patients: A randomized, double-blind, placebo-controlled clinical trial. J Med Plants ;— Behradmanesh S, Derees F, Rafieian-Kopaei M.

Effect of salvia officinalis on diabetic patients. J Renal Inj Prev ;—4. Jayagopal V, Albertazzi P, Kilpatrick ES, et al. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Kumar V, Mahdi F, Singh R, et al.

A clinical trial to assess the antidiabetic, antidyslipidemic and antioxidant activities of Tinospora cordifolia in management of type - 2 diabetes mellitus. Int J Pharm Sci Res ;— Sangsuwan C, Udompanthurak S, Vannasaeng S, et al.

Randomized controlled trial of Tinospora crispa for additional therapy in patients with type 2 diabetes mellitus. J Med Assoc Thai ;—6. Chen H, Karne RJ, Hall G, et al.

High-dose oral vitamin C partially replenishes vitamin C levels in patients with type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance.

Am J Physiol Heart Circ Physiol ;H— Bhatt JK, Thomas S, Nanjan MJ. Effect of oral supplementation of vitamin C on glycemic control and lipid profile in patients with type 2 diabetes mellitus.

Int J Pharm Pharm Sci ;—7. Tabatabaei-Malazy O, Nikfar S, Larijani B, et al. Influence of ascorbic acid supplementation on type 2 diabetes mellitus in observational and randomized controlled trials; a systematic review with meta-analysis.

J Pharm Pharm Sci ;— Lonn E, Yusuf S, Hoogwerf B, et al. Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: Results of the HOPE study and MICRO-HOPE substudy.

Boshtam M, Rafiei M, Golshadi ID, et al. Long term effects of oral vitamin E supplement in type II diabetic patients. Int J Vitam Nutr Res ;—6. Suksomboon N, Poolsup N, Sinprasert S.

Effects of vitamin E supplementation on glycaemic control in type 2 diabetes: Systematic review of randomized controlled trials. J Clin Pharm Ther ;— Udupa A, Nahar P, Shah S, et al. A comparative study of effects of omega-3 fatty acids, alpha lipoic acid and vitamin e in type 2 diabetes mellitus.

Ann Med Health Sci Res ;—6. Xu R, Zhang S, Tao A, et al. Influence of vitamin E supplementation on glycaemic control: A meta-analysis of randomised controlled trials. Mang B, Wolters M, Schmitt B, et al. Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2.

Eur J Clin Invest ;—4. Blevins SM, Leyva MJ, Brown J, et al. Effect of cinnamon on glucose and lipid levels in non insulin-dependent type 2 diabetes. Diabetes Care ;—7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: A randomized, controlled trial.

J Am Board Fam Med ;— Akilen R, Tsiami A, Devendra D, et al. Glycated haemoglobin and blood pressurelowering effect of cinnamon in multi-ethnic type 2 diabetic patients in the UK: A randomized, placebo-controlled, double-blind clinical trial.

Diabet Med ;— Suppapitiporn S, Kanpaksi N, Suppapitiporn S. The effect of cinnamon cassia powder in type 2 diabetes mellitus. JMed Assoc Thai ;89 Suppl. Allen RW, Schwartzman E, Baker WL, et al. Cinnamon use in type 2 diabetes: An updated systematic reviewand meta-analysis.

Ann FamMed ;—9. Eriksson JG, Forsen TJ, Mortensen SA, et al. The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus.

Biofactors ;— Kolahdouz Mohammadi R, Hosseinzadeh-Attar MJ, Eshraghian MR, et al. The effect of coenzyme Q10 supplementation on metabolic status of type 2 diabetic patients. Minerva Gastroenterol Dietol ;—6. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: A systematic review and meta-analysis.

Zahedi H, Eghtesadi S, Seifirad S, et al. Effects of CoQ10 supplementation on lipid profiles and glycemic control in patients with type 2 diabetes: A randomized, double blind, placebo-controlled trial.

J Diabetes Metab Disord ; Suksomboon N, Poolsup N, Yuwanakorn A. Systematic review and metaanalysis of the efficacy and safety of chromium supplementation in diabetes.

Akbari Fakhrabadi M, Zeinali Ghotrom A, Mozaffari-Khosravi H, et al. Effect of coenzyme Q10 on oxidative stress, glycemic control and inflammation in diabetic neuropathy: A double blind randomized clinical trial. Int J Vitam Nutr Res ;— Moradi M, Haghighatdoost F, Feizi A, et al.

Effect of coenzyme Q10 supplementation on diabetes biomarkers: A systematic review and meta-analysis of randomized controlled clinical trials.

Arch Iran Med ;— Ludvik B, Neuffer B, Pacini G. Efficacy of Ipomoea batatas Caiapo on diabetes control in type 2 diabetic subjects treated with diet. Ludvik B, Hanefeld M, Pacini G. Improved metabolic control by Ipomoea batatas Caiapo is associated with increased adiponectin and decreased fibrinogen levels in type 2 diabetic subjects.

Derosa G, Cicero AF, Gaddi A, et al. The effect of L-carnitine on plasma lipoprotein a levels in hypercholesterolemic patients with type 2 diabetes mellitus.

Clin Ther ;— Rahbar AR, Shakerhosseini R, Saadat N, et al. Effect of L-carnitine on plasma glycemic and lipidemic profile in patients with type II diabetes mellitus. Eur J Clin Nutr ;—6.

Derosa G, Maffioli P, Ferrari I, et al. Orlistat and L-carnitine compared to orlistat alone on insulin resistance in obese diabetic patients.

Endocr J ;— Derosa G, Maffioli P, Salvadeo SA, et al. Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients. Intern Med ;— Rodriguez-Moran M, Guerrero-Romero F. Oral magnesium supplementation improves insulin sensitivity and metabolic control in type 2 diabetic subjects: A randomized double-blind controlled trial.

de Valk HW, Verkaaik R, van Rijn HJ, et al. Oral magnesium supplementation in insulin-requiring type 2 diabetic patients. Diabet Med ;—7. Eibl NL, Kopp HP, Nowak HR, et al. Hypomagnesemia in type II diabetes: Effect of a 3-month replacement therapy.

Additionally, should you choose to stop taking the supplements, medications may need to be adjusted again. For some supplements, such as ginseng, the effects may vary from manufacturer to manufacturer or even from batch to batch, as the growing conditions of the plant play a role in its chemical makeup.

This will help you avoid any contraindications that may exist between your medicine and certain types of supplements. The first line of defense when you discover your blood sugar levels are elevated is a lifestyle change.

By altering your diet and exercise habits, you can help eliminate some of the risk factors that worsen diabetes and better control your blood sugar. While there are a variety of medicines that can help your body better regulate glucose, there are also a number of supplements that have shown promising results.

You may find the supplements to be more affordable or convenient than medications prescribed by a doctor. Keep in mind, though, that you need to monitor your blood sugar to ensure that the supplements are helping. Effect of aloe vera on glycaemic control in prediabetes and type 2 diabetes: A systematic review and meta-analysis Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients Fenugreek National Institute of Health.

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Insulin resistance and diabetes Center for Disease Control and Prevention. Metformin: Current knowledge Diabetes risk factors Center for Disease Control and Prevention. Cinnamon: Mystic powers of a minute ingredient Cinnamon use in type 2 diabetes: An updated systematic review and meta-analysis Antidiabetic effects of momordica charantia bitter melon and its medicinal potency Bitter gourd reduces elevated fasting plasma glucose levels in an intervention study among prediabetics in Tanzania Bitter melon Momordica charantia : A review of efficacy and safety Glucose 6 phosphate dehydrogenase deficiency StatPearls.

A simple dietary addition of fenugreek seed leads to the reduction in blood glucose levels: A parallel group, randomized single-blind trial Postprandial glucose-lowering effects of fermented red ginseng in subjects with impaired fasting glucose or type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial Korean red ginseng Panax ginseng improves glucose and insulin regulation in well-controlled, type 2 diabetes: Results of a randomized, double-blind, placebo-controlled study of efficacy and safety Review of ginseng anti-diabetic studies Asian ginseng National Institute of Health.

Silymarin in type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials Milk thistle National Institute of Health. Diabetes and dietary supplements National Institute of Health. Effect of chromium supplementation on blood glucose and lipid levels in patients with type 2 diabetes mellitus: A systematic review and meta-analysis Fiber: The carb that helps you manage diabetes Center for Disease Control and Prevention.

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5 Supplements You Shouldn't Be Taking if You Have Diabetes, According to a Dietitian Therefore, unsupervised supplementation is not recommended if you have diabetes and are taking blood thinners. Florida Can Now Import Prescription Drugs from Canada, Will That Lower Prices? J Altern Complement Med ;—7. These results appear promising, but ensuring that aloe vera is safe and effective for people with diabetes will require further human research. This food combination will not only provide satiating power, but also it will help you up your intake of vitamins, minerals, essential fats and protein. Antidiabetic effects of momordica charantia bitter melon and its medicinal potency
For More Information Protein intake and nutrient absorption J ;— Andersson K, Wändell P, Törnkvist L. Another study used a similar dosage of mg and Fat loss mindset secrets that dosages shpplements to supplemetns are safe for human consumption. Hundreds of dietary supplements including herbals, vitamins and minerals have been reported to have beneficial anti-glycemic effects for patients with diabetes though, in most cases, evidence is of poor quality. Accessed at ods. J Med Assoc Thai ;—6. Momordica charantiaor bitter melonis a medicinal fruit.

Anti-diabetic supplements -

Additionally, the Food and Drug Administration FDA does not regulate herbs and supplements, so some products may contain different herbs and fillers. A person should speak with a healthcare professional before starting any herbs or supplements, especially if they are taking other medications.

Herbs and supplements can cause interactions with prescription medications, and some may be toxic if people take large amounts of them. In this article, learn about seven herbs and supplements that may benefit people with type 2 diabetes.

Aloe vera is a common plant with various uses. Many people are aware of its benefits for the skin, but it may have others, including slowing the progress of type 2 diabetes. One older review , published in , looked at the use of aloe vera to treat symptoms of diabetes in rats.

The findings suggested that aloe vera might help protect and repair the beta cells in the pancreas that produce insulin. A study showed that aloe vera might help lower levels of both fasting blood glucose and hemoglobin A1C. The A1C test is one test that helps doctors diagnose and monitor diabetes.

Another review looked into animal cell studies and found other evidence to support earlier findings, concluding that aloe vera might help:. These results appear promising, but ensuring that aloe vera is safe and effective for people with diabetes will require further human research.

People who use aloe vera may add its juiced pulp to a drink such as a smoothie or take it as a supplement in capsules. People should not ingest aloe vera skin care products.

Anyone interested in using aloe vera products to help treat diabetes should speak with a healthcare professional, who may need to adjust current medications accordingly.

Cinnamon is a fragrant spice that comes from the bark of a tree. It is a popular ingredient in sweets and baked goods, as well as some savory dishes.

This spice may add sweetness to a dish, limiting the need for sugar. It is popular among people with type 2 diabetes for this reason alone, but it may also have other benefits.

A review found evidence from human studies that cinnamon may improve levels of fasting plasma glucose FPG or hemoglobin A1c HbA1c. However, most participants continued their hypoglycemic medications during the study.

Further, only four out of 11 trials reached ADA treatment goals: FPG While HbA1c is one marker that doctors look at when monitoring diabetes, the levels of lipids, cholesterol, and insulin sensitivity are also important.

In addition, a review of 16 studies found evidence that cinnamon could help reduce fasting blood glucose and insulin resistance in people with prediabetes and type 2 diabetes. It is important to note that, overall, most of the relevant studies did not involve human participants. There is a lack of evidence about how cinnamon supplements may affect people.

Before scientists can confirm the effects of cinnamon as a treatment, they need to conduct more research. Momordica charantia , or bitter melon , is a medicinal fruit. People cook it and enjoy it in many dishes. Practitioners of traditional Chinese and Indian medicines have used bitter melon for centuries.

More recently, researchers have been looking into its properties. There is some evidence that bitter melon may help manage diabetes. In a study , 90 participants took either bitter melon extract or a placebo. Those who took the extract had lower fasting blood glucose levels after 12 weeks but no difference in HbA1c levels.

In addition, a recent review notes that people have used many parts of the plant to help treat diabetes, often with positive results.

Taking bitter melon in the following forms may lead to reduced blood sugar levels in some people:. Please note that there is not enough evidence to support using bitter melon instead of insulin or other medications for diabetes.

However, it may help people rely less on those medications. A person should speak with a healthcare professional before starting any herbals as they may interact with current medications. People have long used milk thistle to treat different ailments, especially as a tonic for the liver. Silymarin, the extract from milk thistle that scientists have paid most attention to, is a compound with antioxidant and anti-inflammatory properties.

These may make milk thistle a useful herb for people with diabetes. Many results of investigations into the effects of silymarin have been promising, but not promising enough for experts to recommend the herb or its extract alone for diabetes care, according to one review from The authors of research from found modest evidence that milk thistle might help lower glucose levels in people with diabetes.

They also warned that, while people generally tolerate the herb well, milk thistle could lead to:. Fenugreek is a seed that may help lower blood sugar levels. It contains fibers and chemicals that help slow down the digestion of carbohydrates and sugar. There is also some evidence that the seed may help delay or prevent the onset of type 2 diabetes.

Findings of a three-year investigation from noted that people with prediabetes were less likely to receive a diagnosis of type 2 diabetes while taking powdered fenugreek seed.

The study involved 66 people with diabetes who took 5 grams of the seed with milliliters of water twice a day before meals and 74 healthy participants who did not take it. The researchers concluded that taking the seed preparation led to a reduction in blood sugar resulting from increased insulin levels.

They also found that the preparation led to reduced cholesterol levels. Gymnema sylvestre is an herb that comes from India. One review of cell and rodent studies reported gymnema could:. One human study found those who took a mint containing gymnema reported a lesser desire for sweet treats such as chocolate.

However, it did not include people with diabetes as participants. Still, it may help people with diabetes who would like help reducing their sugar intake. Using either the ground leaf or leaf extract may be beneficial, but a person should speak with a healthcare professional beforehand.

Ginger is another herb that people have used for thousands of years in traditional medicines. Some types of cinnamon contain a compound called coumarin which can raise liver enzymes. Consult your healthcare provider before taking cinnamon supplements if you have liver disease.

If your levels are low, it can have wide-ranging negative effects on your body, including a higher risk of type 2 diabetes. A study found that vitamin D may improve insulin sensitivity, lowering glucose levels and the risk of developing type 2 diabetes.

The researchers examined women in Brazil from the ages of 35 to They found that vitamin D supplements decrease glucose levels. Regular sun exposure was also tied to lower blood sugar levels.

A study found that a two-month regimen of taking daily vitamin D supplements resulted in participants having both improved fasting blood sugar and blood glucose levels. Another study from echoed these findings.

While emphasizing that more research needs to be conducted, the authors concluded that vitamin D supplementation may have beneficial effects on controlling the glycemic indicator.

Consult with your doctor about the best dosage of vitamin D for you before using it. Vitamin D supplements may interact with various medications, including:. Some health risks are associated with taking too much vitamin D. Additionally, too much vitamin D can result in renal failure, but only in extreme cases.

It can also result in the calcification of soft tissues like your heart valves, causing irregular heartbeats and even death. Magnesium is a common mineral that plays a central role in regulating your blood pressure, muscle function, heart rhythm, and blood sugar levels.

In general, diets with higher amounts of magnesium are tied to a lower risk of diabetes, which suggests it plays a role in glucose metabolism. Magnesium supplements come in different forms. Some include magnesium oxide and citrate, as well as chloride.

Magnesium supplements can interact with medications, including antibiotics and diuretics. High doses of magnesium supplements can cause nausea, abdominal cramping, and bloating, as well as diarrhea. Magnesium oxide, chloride, gluconate, and carbonate are the forms that tend to cause diarrhea and other gastrointestinal problems.

Taking large doses of laxatives and antacids that contain magnesium are tied to magnesium toxicity. Bitter melon, or Momordica charantia , is a fruit that has been used for medicinal purposes in Chinese as well as Indian medicine for centuries.

It is often used as an herbal remedy for diabetes because it contains active anti-diabetic substances which are said to lower blood glucose levels. There are not a lot of conclusive studies reviewing the impact of bitter melon on lowering blood sugar levels, but a report does hypothesize that bitter melon capsules contain at least one ingredient for inhibitory activity against the production of a specific enzyme—11β-HSD1.

This is said to break down cortisone to the active form cortisol, leading to hyperglycemia. The authors theorize this inhibitory property might be why this fruit is said to possess anti-diabetic properties.

The sample sizes of most studies included in a separate review were incredibly small. It is hard to definitively say that bitter melon is as effective as more vetted supplements and herbal remedies for lowering blood sugar. The authors concluded that the research is encouraging, but they call for more studies to investigate the benefits of bitter melon.

Bitter melon can be eaten as a whole fruit or squeezed into a juice, or its seeds can be crushed into powdered form for consumption.

Bitter melon extract is also sold as an herbal supplement. For those considering using bitter melon as a supplement to lower blood glucose levels, limit how much you eat or take, since consuming it in excess can result in diarrhea as well as mild abdominal pain.

There may be a risk of hypoglycemia, or extremely low blood sugar, when taken with insulin. One case report suggests that use of bitter melon could result in paroxysmal atrial fibrillation , where a rapid heartbeat begins suddenly and goes away on its own in seven days.

Gymnema, or Gymnema sylvestre, is a perennial woody vine found in tropical regions of India, China, Australia, and parts of Africa.

It is often used in Ayurvedic medicine. One study out of looked at the impact of taking to mg of gymnemic acid. An earlier study in looked at participants with type 2 diabetes given mg of gymnema every day for a period of three months.

Also, diabetic symptoms such as thirst and fatigue were less prominent, lipid levels improved, and levels of a type of hemoglobin bound to glucose known as glycated hemoglobin decreased. Gymnema can be taken in the form of an extract, tea, or powder. You can also chew on the leaves of the plant itself and can find gymnema in capsule form.

If you opt for the capsule form of gymnema supplements, you should consult with your doctor or healthcare provider about the best dosage for you. As always, consult with your provider before using any new supplement. Given that gymnema can regulate blood sugar levels in people with diabetes, look out for signs of hypoglycemia and monitor your blood sugar.

Since it can impact blood sugar levels, it might affect blood sugar control during as well as after a surgery. Consult your provider and let them know you are using this supplement before going in for any surgical procedure.

Be careful about how gymnema might interact with other blood sugar-lowering medications. Stay on top of your blood sugar levels and consult your healthcare provider if you worry your glucose levels are too low.

This might impact the recommended dosage of either gymnema or insulin. American ginseng , also called Panax quinquefolius , is an herb commonly used in traditional Native American and Chinese medicine.

One study of 39 people living with diabetes found that the herb, coupled with fiber, helped lower blood sugar levels over the course of 12 weeks.

However, the authors made it clear that more research needs to be done to better understand the health impacts of this herbal supplement. That was the similar conclusion of the authors of a review of 16 different studies.

They looked at randomized, controlled trials that took place for a month or longer among people with and without diabetes. They found that those who used ginseng herbal supplements had significantly improved blood sugar levels compared to the control groups.

You can get ginseng as an extract or in capsule form. As with other supplements, herbal treatments like ginseng are highly unregulated and there is no standardized dosing to adhere to. Consult your doctor or healthcare provider about best ways to incorporate this herbal supplement into your diet or regimen.

Ginseng has been found to have moderate interactions with diabetes medications like insulin and sulfonylureas, including Amaryl glimepiride , DiaBeta glyburide , and Glucotrol glipizide. These interactions could result in hypoglycemia.

Ginseng products may also interfere with Coumadin warfarin , a blood thinner. In general, ginseng is found to be a safe supplement, but some people have reportedly experienced insomnia, diarrhea, headaches, and anxiety while using this herbal treatment.

Chromium is a natural mineral found in certain foods. The trivalent form is what you will most likely encounter and is found in foods. However, you should steer clear of its hexavalent form, which is toxic and found in industrial waste and pollution.

A review found favorable effects of chromium supplementation on glycemic control in patients with diabetes. There is no established Recommended Daily Allowance RDA for chromium.

Generally, multivitamin or mineral supplements that contain chromium have doses of mcg. You can also find supplements that are exclusively chromium, which provide mcg to mcg of the mineral. Some can go as high as 1, mcg, but they are not as common. Some medications may interact with chromium supplements.

Insulin is one, as taking it with chromium increases the risk of hypoglycemia. Metformin and other diabetes medications taken together with chromium also carry this risk.

Individuals with renal and liver disease may suffer from worse symptoms of their condition if they take a lot of chromium. Some isolated symptoms include weight loss, anemia, liver dysfunction, thrombocytopenia, renal failure, rhabdomyolysis, dermatitis, and hypoglycemia.

Berberine is a included in a wide range of supplements and has been a staple of traditional Chinese and Indian medicine.

It's been used in the treatment of type 2 diabetes, hypertension, and hyperlipidemia. A study examined 80 people who were in the hospital for metabolic syndrome from January to December The researchers concluded that berberine-based therapy regulated blood glucose and alleviated insulin resistance.

A meta-analysis concluded that berberine is a good option for treating conditions like type 2 diabetes in people of lower socioeconomic status because it's relatively low cost and effective with no serious side effects.

As with other herbal supplements, more research on the benefits of berberine needs to be conducted. Taking mg of berberine two to three times a day for up to three months could be an effective way to control blood sugar levels. Berberine does have some interactions with medications you may already be taking.

Keep in mind this is not an exhaustive list and that there may be other interactions:. Berberine could cause some gastrointestinal problems like diarrhea, cramping, or constipation.

It is unsafe to use on newborns, and people who are pregnant or breastfeeding should avoid using this supplement. Alpha-lipoic acid is a compound found inside each cell in the human body.

It converts your glucose into energy by way of oxygen. This is called aerobic metabolism. A study surveyed 38 people with type 2 diabetes who were put on daily , , , and 1, mg treatments of alpha-lipoic acid over six months.

After treatment, the participants were monitored for their glucose status and oxidative biomarkers. A review examined a series of studies on the effectiveness of alpha-lipoic acid. The analysis offers a mixed bag. While some of the research was encouraging, others showed alpha-lipoic acid to be no more effective than placebos administered to participants.

Overall, the authors suggested that more studies with larger sample sizes are needed to determine effectiveness. Dosage of alpha-lipoic acid greatly varies. One study cited a dosage range from mg to as high as 1, mg daily before eating.

Alpha-lipoic acid can interact with some medications, including diabetes medications, chemotherapy medications, thyroid medications, and vitamin B1. As always, consult with your healthcare provider before adding any new supplement to your treatment regimen.

In general, alpha-lipoic acid is fairly safe to take and side effects are rare. Known side effects include fatigue, diarrhea, skin rash, and insomnia. Given that alpha-lipoic acid lowers blood sugar, people with already low blood sugar levels and diabetes should consult with their doctor or healthcare provider before adding this to their treatment regimen.

Probiotics are healthy bacteria found in certain foods that may help reduce blood sugar in people with diabetes. These "good" bacteria help support the natural environment of bacteria and fungi in the gut and, by doing so, aid in the digestion of carbohydrates that might otherwise give rise to hyperglycemia.

In addition to probiotic foods, there are probiotic supplements that can deliver these "good" bacteria to your body in a large concentrated dose. A review of studies involving 20 randomized controlled trials and 2, participants concluded that probiotic supplements were especially good in managing blood surgery in people with gestational diabetes , the type that can develop during pregnancy.

In addition to supplements, probiotics are found in fermented foods like:. When taken as a supplement, a daily dose of between 10 to 20 billion CFU colony-forming units is considered safe and effective in maintaining a healthy balance of bacteria in your gut. Probiotics are generally considered safe but may cause side effects in some, including mild stomach upset, diarrhea, gas, and bloating.

These tend to occur during the first few days of treatment but will generally subside as your body gets used to the supplements. Nigella sativa , also known as black cumin seed or simply black seed, is a naturopathic remedy thought to have blood sugar-lowering properties.

Proponents suggest that it can treat a wide range of medical conditions, including high blood pressure, skin infections, diarrhea, liver disease, and others. A review of studies suggested that Nigella is able to lower blood sugar in people with type 2 diabetes by increasing not only insulin sensitivity but overall insulin levels.

The compound thought to effect these changes is an essential oil known as thymoquinone. Despite the positive findings, the quality of the seven reviewed studies was poor. Nigella supplements are sold online and in many drugstores and supplement shops. The manufacturer's recommended daily intake is between 1, and 2, mg per day taken in a single dose.

The supplement is typically sold as a gel cap containing black cumin seed oil. Nigella sativa is generally regarded as safe when used for culinary purposes or taken as a daily supplement.

Even so, it can cause stomach upset, gas, bloating. nausea, vomiting, or constipation, especially when taken at higher doses. It can also interact with certain drugs used to treat high blood pressure. If you are being treated for high blood pressure, speak with your healthcare provider before using Nigella in any form.

Researchers have long recognized that many people with type 2 diabetes have zinc deficiency , leading some to assume that zinc supplements may help improve blood sugar control. To date, the evidence of this remains mixed. Although a review of studies suggested that zinc supplements ranging from 5 to 50 mg showed promise in managing blood sugar in people with type 1 and type 2 diabetes, neither the findings nor the quality of the studies were consistent.

Even so, the use of zinc supplements was considered reasonable given the many complications that can arise with zinc deficiency including vision problems, fatigue, skin changes, and an increased risk of infection.

The recommended daily intake of zinc from all sources is 11 mg per day for adult males and 8 mg per day for adult females. Pregnancy and breastfeeding require slightly higher doses 11 mg and 12 mg respectively ,. In addition to supplements, excellent food sources of zinc include:.

You generally can't "overdose" on zinc because it is readily excreted from the body in urine. Even so, taking high doses all at once may cause side effects like headache, nausea, stomach upset, diarrhea, and vomiting.

Zinc can also interfere with the absorption of nonsteroidal anti-inflammatory drugs NSAIDs like Aleve naproxen and Indocin indomethacin , making these painkillers less effective.

Other supplements thought to improve blood sugar in people with diabetes include folate and omega-3 fatty acid found in fish oil. American Diabetes Association Professional Practice Committee.

Facilitating behavior change and well-being to improve health outcomes: standards of medical care in diabetes— Diabetes Care. Suksomboon N, Poolsup N, Punthanitisarn S. Effect of aloe vera on glycaemic control in prediabetes and type 2 diabetes: a systematic review and meta-analysis.

J Clin Pharm Ther. Zhang Y, Liu W, Liu D, Zhao T, Tian H. Efficacy of aloe vera supplementation on prediabetes and early non-treated diabetic patients: a systematic review and meta-analysis of randomized controlled trials.

Guo X, Mei N. Aloe vera : a review of toxicity and adverse clinical effects. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev.

Download Anyi-diabetic. Hundreds Anti-diabetic supplements dietary Potassium and memory improvement Lean protein sources for breakfast herbals, supppements and minerals have been eupplements to have beneficial anti-glycemic effects spplements patients with ssupplements though, in most Anti-diabetic supplements, evidence Fast-acting pre-workout of poor quality. The best current evidence on Anti-idabetic is presented Lean protein sources for breakfast. Note: Please refer to the Passport to Whole HealthChapter 15 on Dietary Supplements for more information about how to determine whether or not a specific supplement is appropriate for a given individual. Supplements are not regulated with the same degree of oversight as medications, and it is important that clinicians keep this in mind. Products vary greatly in terms of accuracy of labeling, presence of adulterants, and the legitimacy of claims made by the manufacturer. Many modern pharmaceuticals have natural plant origins. Anti-diabetic supplements


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