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Ginger for immune system

Ginger for immune system

Global News Facebook Pages Subcutaneous fat burning foods News Twitter Entice your palate with thirst satisfaction Global News Youtube Sstem Global News on Instagram Global Entice your palate with thirst satisfaction on Systtem Global News on TikTok Global News on Telegram. When you take ginger regularly it may systtem the effect of preventing an illness or at least lessening the duration and symptoms. Health Tools. In vivothe lemon and ginger combination water extract induced a significant decrease in percentage change in tumor size, a high percentage of mice with no detectable tumor, and low average tumor weight g Table 2. However, the authors noted that the studies in their meta-analysis were small and may not represent the general population. Medically reviewed by Natalie Olsen, R. Ginger for immune system

Ginger for immune system -

Results are shown as means bars SEM lines. The colorimetric assay of caspase-3 activity was conducted using the caspase-3 assay kit to estimate the impact of lemon and ginger combination water extract on the caspase-3 levels of the MDA-MB cell line.

At the concentration of 3. In contrast, vincristine showed a value equivalent to 5. Figure 3. Folds of caspase-3 activity and apoptosis induction in IC 50 concentrations of vincristine 0. The combination of lemon and ginger induced lymphocytes cell proliferation in the presence of Con A and LPS Figure 4.

The viability cell index of the lemon and ginger combination water extract was 0. Figure 4. A The effect of lemon and ginger combination water extract at various concentrations 25—3. B The effect of lemon and ginger combination water extract at various concentrations 25—3.

C The effect of lemon and ginger combination water extract at various concentrations 25—3. Results are expressed as means of three independent experiments bars ± SEM lines. The lemon and ginger combination water extract showed no phagocytic activity with a percentage value of Figure 5. In vitro phagocytic assay utilizing nitro blue tetrazolium NBT reduction test of peritoneal macrophage treated with different concentrations of lemon and ginger combination water extract for 48 h.

Figure 6. The effect of lemon and ginger combination water extract on macrophage pinocytosis. A significant decrease in tumor size was noticed in tumor-bearing mice treated orally with the lemon and ginger combination compared with the negative control that showed tumor growth increased by Table 3.

Effect of lemon and ginger combination water extract on tumor size and cure percentage. The lemon and ginger combination recorded a percentage in tumor reduction of On the other hand, treated mice showed normal activity with no side effects.

Figure 7. A plot of change in average tumor size mm 3 vs. Figure 8. Combination therapy resulted in a high cure percentage and small tumors size.

There were 10 mice in each group. Herbs are viewed to be of high value to the health of individuals and communities in general.

The medicinal benefit of plants lies in some chemical substances which have specific physiological effects on the human body No previous studies have examined the antiproliferation activity of the lemon and ginger combination water extract on the aforementioned cell lines.

However, many studies have investigated the antiproliferation activity of each extract against selected cell lines.

Lemon has shown the presence of different indolofuroquinoxaline derivatives, which exhibited antiproliferative activity against leukemia and human breast cancer cells. On the other hand, there was no significant activity against the normal cell line Meanwhile, ginger has been reported to have a cytotoxic effect against human breast cancer cell lines MDA-MB The ability of ginger to inhibit cell growth was due to the presence of [6]-gingerol as it hindered the activity of matrix metalloproteinases MMP -2 and MMP-9 in the human breast cancer cells The lemon and ginger combination water extract revealed synergic effect in reducing cancer cells proliferation in vitro.

This finding is compatible with a previous study, which reported the ability of lemon and garlic water extract to induce apoptosis and prevent carcinoma development BR35A,.

However, the potent anticancer response of the lemon and ginger combination water extract was observed to be mediated by diverse anticancer mechanisms, which may be explained by the existence of various phytochemicals compounds. The observed proliferation inhibition in the cells treated with the lemon and ginger combination water extract is basically because of the impact of different antiproliferation factors.

The cytotoxic potential of alpha-pinene was examined in two different human cell lines human ovarian cancer cell line SK-OV-3 and human hepatocellular carcinoma cells Bel Also, it was studied against the human histiocytic lymphoma U cell line Furthermore, a previous study confirmed that alpha-pinene has an antiproliferation effect through provoking oxidative stress and associated signaling cascade against human lung cancer A and human liver cancer HepG2 These previous findings are consistent with this study.

On the other hand, α-pinene was found to have no antiproliferation activity against melanoma cells in vitro This may be justified by the fact that solid tumors have different responses to phytochemicals as α-pinene. Other highly concentrated compounds in the combination extract are alpha-terpineol 7.

Alpha-terpineol has demonstrated antioxidant ability against peroxyl radicals and has been shown to have a cytostatic impact against six human cancerous cell lines from five diverse histologic and embryonic origins breast, lung, prostate, ovarian, and leukemia Furthermore, terpinenol was found in the combination extract to a significant degree.

It caused necrotic cell death coupled with less activity of apoptosis process in both murine malignant mesothelioma cell line AE17 and murine B16 melanoma cells.

The inhibitory impact of terpinenol is achieved through the elicitation of the G1 cell cycle arrest Further analysis of the lemon and ginger combination water extract revealed the presence of geraniol, citral, δ-elemene, camphene, and borneol in notable percentages and the previously reported activity of these components confirms the results of this study.

Based on a previous study, the growth of prostate cancer cells was inhibited by the effect of geraniol compound on inducing the apoptosis and autophagy process Citral prevents the proliferation of breast cancer cells MDA MB cells in vitro , mainly through the initiation of apoptosis, antimetastasis, and antiangiogenesis potentials In colorectal adenocarcinoma DLD-1 , the antiproliferative activity of δ-elemene was implemented by the activation of mitochondrial caspase-dependent and caspase-independent pathways On the other hand, camphene exhibited anticancer activity in melanoma cells both in vitro and in vivo.

It can disrupt the mitochondrial membrane potential and enhances the caspase-3 effect In a previous study, borneol NB improved the absorption of selenocysteine; as a result, it increased his apoptotic activity against human hepatocellular carcinoma cells.

Also, they reduced tumor growth by provoking ROS-mediated DNA damage In the current study, the potential inhibition of cancer cell growth by lemon and ginger combination may due to the effects of the nine major compounds previously mentioned and to the other active minor components. To gain further in-depth knowledge of the mechanisms of action of the combination extract under study, the lemon and ginger combination was further tested for its ability to inhibit angiogenesis.

The VEGF is a potent signal protein that stimulates angiogenesis. VEGF upregulation is a well-known mechanism in many types of tumors and the inhibition of this pathway is an interesting target in cancer prevention and therapy In our study, the lemon and ginger combination showed a strong ability to suppress the MDA-MB human breast cancer angiogenesis.

Further examination showed that the lemon and ginger combination water extract had a potent anticancer effect in vitro. The combination has potent apoptosis induction activity and potent VEGF inhibition in the MDA-MB cell line.

In MDA-MB cells, nuclear factor kappa B NF-κB is involved in the upregulation of VEGF mRNA then increases the angiogenesis The activations of NF-κB were attenuated utilizing α-pinene treatment In HeLa cells, alpha-terpineol repressed TNF-α and NF-kB translocation into the cell nucleus.

Repression of NF-kB activation can result in the decrease of cyclin D expression, an essential protein in the induction of the G phase of the cell cycle Meanwhile, geraniol is a strong agent with antiangiogenic properties These results are inconsistent with the findings of this study.

Another mechanism responsible for the observed anticancer activity is apoptosis programmed cell death induction. In cancer, this process is inoperative, due to the upregulation of antiapoptotic genes and the downregulation of apoptotic genes; therefore, cells continue dividing and proliferating One of the targeted pathways in cancer treatment is the activation of apoptosis.

In our study, the lemon and ginger combination herbal drink was found to have the ability to induce apoptosis in the MDA-MB cell line 4. Both hesperidin flavonoid 54 , and eriocitrin flavonoid 55 in lemon cause apoptosis induction and inhibit the human hepatocellular carcinoma.

The high antiproliferative activity of lemon has been explained in previous studies, which have shown that the methanol extract of lemon has anticancer activity toward MCF-7 breast cancer cells via Bax-related caspase-3 activation.

Alpha-pinene, which is found in high percentages in the lemon and ginger combination, was also capable of inducing apoptosis, as evidenced by the rise in caspase-3 activity Moreover, geraniol has the most dominant apoptosis-inducing activity among terpenoids against shoot primordia of Matricaria chamomilla ; it causes DNA fragmentation in the cells.

The activity of geraniol is concentration- and time-dependent The immune system is a sophisticated defense system in vertebrates, having the role of protecting them from numerous types of foreign infectious agents that they encounter during their lifetimes.

It uses a variety of cells, tissues, and organs and is capable of recognizing and eliminating invasions There has been a growing interest in identifying and characterizing natural compounds with immunomodulatory activities.

Three immune assays have been conducted, namely, lymphocytes proliferation, phagocytosis, and pinocytosis assays. Lymphocytes proliferation assay was conducted three times: splenic lymphocytes with extract alone, splenic lymphocytes with extract and Con A, and splenic lymphocytes with extract and LPS, for lemon and ginger combination water extract.

The volatile oil of ginger exhibited significant suppression of the mitogen-stimulated T-lymphocyte proliferation in mice 60 , which agrees with our result.

While citrus peels had a mitogenic response to con A In addition to that, both lemon citrus and ginger stimulate innate immunity 61 , These previous studies conflicted with our results may be due to the antagonistic effect of the combination on the activity of both lemon and ginger.

For pinocytic activity, the potent pinocytic activity was the lemon and ginger combination. Various groups of phytochemicals are found in the lemon and ginger combination water extract.

This could explain the activation of a specific anticancer response, such as immune enhancement It is worth mentioning that a -pinene exhibited anti-Leishmania activity via macrophage stimulation with minimum cytotoxicity Citral influences cytokines production by activation of murine macrophages through the prevention of the transcription factor NF-κB In the cell-based assay, terpinenol was able to modulate apoptosis and immune system activity in a way that reduced the cell growth of melanoma cells In agreement with these previous studies, the results of this study showed that the lemon and ginger extract possesses strong antiproliferation and pinocytosis activity.

This study results showed a significant reduction in tumor sizes in all treated mice. On the other hand, no previous study has examined the in vivo tumor-prevention activity of lemon and ginger combination water extract. Besides cancer chemotherapy strategies, using dietary agents such as fruits and vegetables help the prevention of tumor growth.

Extracts derived from fruits and vegetables are demonstrated to have antiproliferative effects It is extensively acknowledged that chemopreventive agents, as lifestyle and dietary habits, have more superior potential in the long term than chemotherapeutic agents, especially in prostate cancer growth and progression In vivo , the lemon and ginger combination water extract induced a significant decrease in percentage change in tumor size, a high percentage of mice with no detectable tumor, and low average tumor weight g Table 2.

A cohort study confirms that the daily consumption of citrus fruits is associated with a decreased risk of gastric cancer In vivo , alpha-pinene pretreatment reduced the production of the pancreatic tumor necrosis factor, interleukin IL -1beta, and IL-6 during the induction of acute pancreatitis by cerulean There is an interaction between the work of lemon and ginger combination resulted in antitumor activity in vitro and in vivo.

Furthermore, the anticancer activity could be explained by the stimulation of apoptosis and pinocytosis and reduction of VEGF expression. Lemon and ginger herbal combination is a healthy drink with anticancer and immunomodulatory health benefits. Its anticancer effect is mediated by apoptosis induction and angiogenesis inhibition.

The immunomodulatory effect is mediated through the activation of the innate immune system. The health benefits of this herbal drink are mainly due to the presence of biologically active phytochemicals in ginger and lemon.

Further studies are needed to have a better understanding of the mechanisms of action of the herbal drink. The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. The animal study was reviewed and approved by Institutional Research Board at Applied Science Private University.

The project idea was developed by WT. IA-A performed the sample collections and ran the laboratory experiments.

Both authors developed the experimental design, analyzed the data, and wrote and revised the manuscript. We are grateful to the Applied Science Private University, Amman, Jordan for the full financial support granted to this research project.

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers.

Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in countries.

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Mediterranean diet and cancer: epidemiological evidence and mechanism of selected aspects. BMC Surg. Olaku O, White JD. Herbal therapy use by cancer patients: a literature review on case reports. Eur J Cancer. Zhou Y, Zheng J, Li Y, Xu D-P, Li S, Chen Y-M, et al.

Natural polyphenols for prevention and treatment of cancer. Talib WH. A ketogenic diet combined with melatonin overcomes cisplatin and vincristine drug resistance in breast carcinoma syngraft. Regressions of breast carcinoma syngraft following treatment with piperine in combination with thymoquinone.

Sci Pharm. Qingming Y, Xianhui P, Weibao K, Hong Y, Yidan S, Li Z, et al. Antioxidant activities of malt extract from barley Hordeum vulgare L.

toward various oxidative stress in vitro and in vivo. Food Chem. Talib WH, Al-Hadid SA, Ali MBW, Al-Yasari IH, Abd Ali MR. Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action.

Breast Cancer Targets Ther. Yu MH, Gwon Im H, Gyu Lee S, Kim D-I, Jeong Seo H, Lee I-S. Inhibitory effect of immature plum on PMA-induced MMP-9 expression in human hepatocellular carcinoma.

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Did you know a cup of ginger tea might be good for your teeth? Ginger contains antimicrobial and antifungal properties that can help to kill off harmful oral pathogens.

This can help to improve your overall health and keep your teeth safe and healthy. Ginger is often combined with turmeric in many tea blends.

Ginger and turmeric are actually close relatives, and contain many of the same beneficial properties. Some of the benefits of turmeric include:. How you prepare different kinds of ginger tea will depend on what other ingredients are in the blend. For herbal and black teas, we recommend using boiling water to steep the tea leaves for the most flavorful cup.

For green tea, on the other hand, you should use cooler water that is steaming, but not boiling. The longer you steep tea with ginger in it, the more pronounced the spicy-sweet ginger flavor will be.

You should steep green teas with ginger for around two minutes, black teas with ginger for three to five minutes, and herbal teas with ginger for five minutes or more.

We carry a wide variety of ginger teas, from spiced chai blends to healthful herbal teas and everything in between. Ginger root contains no caffeine, and many herbal tea blends that contain ginger are caffeine-free.

That said, some caffeinated blends also contain ginger, like chai tea or lemon ginger green tea. Whether or not a particular tea contains caffeine will depend whether or not it contains true tea from the camellia sinensis plant. Plus, ginger is often blended with other relaxing ingredients, like lemongrass and mint.

However, it may be blended with other tannic ingredients, like black tea. Yes, ginger tea is an effective herbal remedy to help treat symptoms of nausea. A cup of ginger tea can help to soothe your upset stomach. Ginger tea is a good digestive aid, and can help to ensure that your digestion system is working properly, including reducing symptoms of bloating.

Your cart is empty Continue shopping Have an account? Loose Leaf Tea Our loose leaf tea collection features over exceptional teas, many of which Loose Leaf Tea. Your cart. Add a gift note or additional info Add a gift note or additional info. Instead of straining the mixture, you can simply blend it until it is smooth or dilute the shot with extra water.

This way, you can still enjoy the benefits of ginger while retaining all of the fiber and additional nutrients. You can easily turn your prebiotic ginger shots into probiotic ones by adding ml of fermented water kefir or a few tablespoons of raw fermented brine from fermented veggies like sauerkraut.

Wondering what the difference is between pre biotic and pro biotic? Prebiotics on the other hand refer to foods that feed the bacteria. An example of a prebiotic is fiber, it passes through your body undigested and eventually reaches your gut bacteria, which is why fiber is so important to include in your diet.

Your shots will store in the fridge for up to five days in a closed container, but if you're batch prepping or just making a big portion in one go you can also freeze them for up to three months! A quick tip is to pour your shots into an ice-cube tray and then transfer them into a freezer bag or container for even easier access!

This way you can vary flavours throughout the week no monotonous routines here. You can also customize your ginger shot by adding other ingredients like cayenne pepper, chili, mint and even coriander for added health benefits. Please note, comments need to be approved before they are published.

Item added to your cart. Check out Continue shopping. Share Share Link. Why Drink Cleansing Ginger Shots?

If immunw looking for an easy and tasty way to boost your immune Glnger and Gingeer the many health benefits Multivitamin supplements Entice your palate with thirst satisfaction, give these Dystem ginger shot recipes a try! With just a few ingredients, forr can make a powerful, Glycogen replenishment for optimal recovery nutrient-packed systsm shot in minutes! Ginger is a root that has been used for centuries in traditional medicine for its numerous health benefits. It has anti-inflammatory and antioxidant properties that can help reduce nausea, supports digestion, relieve cold and flu symptoms and boosts immunity. It's a perfect way to cleanse your body after the holidays or big stressful events in your life. A ginger shot is a concentrated dose of ginger that is consumed in a small amount, typically 30mlml. Drinking a ginger shot can provide a quick and easy way to incorporate the health benefits of ginger into your daily routine. For Detoxification and inflammation reduction of years, ginger has been used ummune cooking Glycogen replenishment for optimal recovery Ginnger Entice your palate with thirst satisfaction over the world. Numerous studies have found that ginger can Ginnger improve blood sugar levels, reduce inflammation, relieve pain, strengthen the immune system, and treat nausea and indigestion. Learn about the benefits of this funky rhizome and how to incorporate it into your life. Ginger contains a potent compound called gingerol. It has powerful anti-inflammatory and antioxidant properties.


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