The IHG distributions during aging Fig. Sysstem baseline IHG-IV, a Wound healing cream IR metric, associated with a nearly 3-fold increased risk of subsequently acquiring HIV, after controlling for level of risk factors. Gaffen, S.

Immune system resilience -

Please do not take supplements, whether nutrients, herbs, or other compounds without consulting your care team. The effectiveness of supplements can be altered by product quality, concentration of active ingredients, and interactions and should be personalized for you by a professional.

There are no known preventive, curative, or confirmed therapeutic agents for COVID, however, researchers are exploring anti-viral therapies and vaccine trials are underway with some promising leads.

Source , Source , Source , Source , Source The most important thing we can do is to stay healthy by whatever means we can. The following is general information about the actions of certain foods, nutrients, and compounds.

Please focus on food first, and use caution before introducing any of the following measures. These should not replace formal, personalized advice that considers your health status, health history, medications, and supplements.

Again, information is not intended to diagnose, treat, or prevent any condition and should be discussed with your healthcare team and physician.

Again, no foods, nutrients, or supplements have been shown to prevent or mitigate this virus, but many play supportive roles in immune function, especially for those individuals with nutrient deficiencies or nutrient-poor diets.

By optimizing our health, we may be able to reduce the strain on our overburdened healthcare system. Americans seem to be turning to comfort and convenience foods during this time of hunkering down. Source Instead of relying on shelf-stable and processed foods, focus on eating real foods that can build resilience and optimize your immune function.

Choose fresh or frozen foods whenever possible. There are over flavonoids that contribute protective benefits and colorful pigments to fruits, herbs, vegetables, and medicinal plants. Beverages such as black tea, green tea, red wine also contain a variety of flavonoids with a variety of benefits.

Source , Source. The composition and function of the microbiome can be rapidly altered by what we eat, for better or for worse.

Source Some general principles apply to support immunity via the microbiome: include prebiotic fibers like the ones mentioned above, and include probiotics from foods like lacto-fermented vegetables think sauerkraut, kimchi, fermented pickles, kombucha, kvass, etc.

One of the best things you can do to improve the quality of your diet is to avoid sugars including sodas, fruit juices, and desserts. Sugar can suppress the action of white blood cells in your immune system for hours after you eat it. With more time spent at home, many of us have new opportunities to practice new skills and recipes.

Get creative by including kids in the kitchen, or video-chat a friend and cook together! Clean water is crucial. Aim to drink about half your body weight in ounces each day i.

if you weigh lbs, aim to drink 75oz of water daily. Stress is an important factor in immunity since stress hormones such as adrenaline and cortisol weaken immune function. During times of stress, we may actually need more nutrients, reemphasizing our need for a variety of whole, unprocessed foods.

Practice mindful eating, and notice if you have started heading for sugary, salty snacks. This is a difficult time, and if you notice that you are eating as an emotional response instead of experiencing physical hunger, you may consider speaking with someone who can help or expressing stress in other ways like physical activity, meditation, art, and engaging with loved ones.

Doing so may promote feelings of wellbeing and promote a parasympathetic response. Social isolation can increase fears and feelings of loneliness, acting as immunosuppressants. Share time with your favorite people, whether virtually or in-person with those in close proximity.

When we feel loved, relaxed, and happy, we produce neuronal signaling molecules such as serotonin, dopamine, and relaxin which have a strengthening effect on the immune system.

Vitamin D is getting a lot of attention due to its role in reducing the risk of acute respiratory tract infections, especially in those who are vitamin D deficient.

Source Optimizing vitamin D status is a safe and likely helpful measure for protecting against respiratory infections in general. Most people do not have optimal levels of Vitamin D, especially in the winter and early spring. Source Vitamin D is best produced through exposure to sunlight, and supplementation can be helpful if hydroxy vitamin D levels are suboptimal.

Source If supplementation is your best option, your practitioner can help you determine your vitamin D status, which will determine dosing. If you have safe access to the outdoors, get outside for at least minutes a day. If you find yourself mostly indoors, sit by an open window to catch some rays of sunlight.

Connect with a personalized nutrition practitioner. What role does personalized nutrition play in immune resilience? Source Personalized nutrition can play an important role in optimizing immunity and preventing and managing inflammatory chronic conditions in high-risk groups.

Source The effects of nutritional interventions in the progression of chronic diseases can take weeks, months, and even years in some cases. Source This is why it is imperative that you work with a personalized practitioner who understands your immune function, inflammatory status, insulin regulation, and nutrient status.

the way we live and interact with our environment is the major determinant of both our individual and collective health. Follow CDC guidelines. Practice good sanitation like frequent and thorough hand-washing and take social distancing seriously as long as it is recommended.

Clean well and clean often. The investigators have analyzed stored blood samples and publicly available data representing people, many of whom were healthy volunteers, who had enrolled in different studies conducted in Africa, Europe, and North America. Volunteers ranged in age from 9 to years.

They also evaluated participants in the Framingham Heart Study, a long-term effort to identify common factors and characteristics that contribute to cardiovascular disease. To examine people with a wide range of health challenges and associated stresses on their immune systems, the team also included participants who had influenza or COVID, and people living with HIV.

The short answer is that immune resilience, longevity, and better health outcomes tracked together well. Those with metrics indicating optimal immune resilience generally had better health outcomes and lived longer than those who had lower scores on the immunity grading scale.

Indeed, those with optimal immune resilience were more likely to:. The study also revealed other interesting findings. Some people also maintain higher levels of immune resilience despite the presence of inflammatory stress to their immune systems such as during HIV infection or acute COVID People of all ages can show high or low immune resilience.

The study also found that higher immune resilience is more common in females than it is in males. The findings suggest that there is a lot more to learn about why people differ in their ability to preserve optimal immune resilience.

With further research, it may be possible to develop treatments or other methods to encourage or restore immune resilience as a way of improving general health, according to the study team.

It could also help to identify those individuals who may be at a higher risk of poor outcomes when they do get sick and may need more aggressive treatment. Researchers may also consider immune resilience when designing vaccine clinical trials. A more thorough understanding of immune resilience and discovery of ways to improve it may help to address important health disparities linked to differences in race, ethnicity, geography, and other factors.

NIH Support: National Institute of Allergy and Infectious Diseases; National Institute on Aging; National Institute of Mental Health; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute.

This research was supported in part by NIA grants AG and AG and the Intramural Research Program at NIA. Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection.

Nature Communications. doi: Immunologic resilience and COVID survival advantage. Journal of Allergy and Clinical Immunology. Epub Sept. An official website of the National Institutes of Health.

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