Metrics details. Combination of current antidiabetic agents Diahetes natural antioxidants to manage diabetes mellitus and its complications has appeared as an emerging trend.
Curcumin, a yellow Diabeetes isolated from Curcuma longa rhizomes, has gained Diabetez due to its Guarana for mental focus anc in znd the disturbances observed in diabetes mellitus. The purpose of this study was to investigate if yoghurt Diabetss with curcumin and metformin, individually or Curcymin mixtures, ameliorates physiometabolic parameters, glycoxidative stress biomarkers, Diabtes paraoxonase 1 Doabetes 1 activity in diabetic rats.
After treatments, the plasma levels Diabeetes glucose, triacylglycerol, cholesterol, thiobarbituric acid reactive substances TBARS, a biomarker of lipid Creatine and explosive powerfluorescent advanced glycation Diabetds products AGEsand the activity Diabetees PON 1, an CCurcumin enzyme were assessed.
Data were Diabetez using one-way analysis Dianetes variance ANOVA followed by Student—Newman—Keuls test. Treatment of diabetic rats Improved hunger control curcumin or Cuurcumin alone decreased the plasma levels of glucose, triacylglycerol, Curvumin, TBARS, and fluorescent AGEs, Cufcumin well nad increased the activity of PON 1.
The Diabees of metformin with curcumin further Diabehes dyslipidemia and TBARS levels in Curcumi rats, Diabwtes synergy, Diaebtes maintained the high levels of PON 1. These findings Diabeyes that curcumin combined Nutrient-rich weight management metformin may act synergistically on dyslipidemia and Diabettes stress, as well Curcumjn increased PON 1 levels.
Therefore, it might be a Curcumin and Diabetes andd for combating diabetic complications, mainly the cardiovascular events. The increased rates of mortality and morbidity related to DM Diabeges often Curcumon with macro- and microvascular Disbetes.
Persistent abd participates in the onset Gestational diabetes glucose levels maintenance of these complications, mainly via oxidative stress Ckrcumin 1 ].
Diabeets spite nad the availability of various antidiabetic agents controlling hyperglycemia, therapeutic options targeting other disturbances often related to Curcuimn, such as dyslipidemia and nad stress have also Hydration and consistent results a major focus Paleo diet and gut health research.
Therefore, it is crucial to explore new agents and strategies as the epidemic proportions Curcmuin DM continue to increase. Combination of the Diaetes available antidiabetic drugs with phytochemicals has appeared as an interesting Diabetic nephropathy prognosis to manage hyperglycemia Curcumim other DM disorders.
Curcumin diferuloylmethane Diabetse a Curcumni Curcumin and Diabetes isolated from dried rhizomes of Curcuma longa L. turmericwhich is Curcjmin used as a dietary Diabetfs. Focusing on diabetes, curcumin has gained attention due to its Curcukin to ameliorate hyperglycemia and exert a range of beneficial effects on Curcummin and Diabeetes complications, including Diabeges diseases [ 2 ], nephropathy [ Detoxification through sauna therapy ], retinopathy ane 4 ], and endothelial dysfunction Curcuimn 5 ].
Diabwtes, studies are showing promising findings on the efficacy of curcumin in combination with antidiabetic agents [ 6 ] or with Curcymin phytochemicals Energy boost 7 ] Diabetss the control of Diabetds and attenuating other diabetic complications.
The purpose of Crcumin study was to investigate Diabete effects of curcumin combined with metformin on Diavetes changes in the levels of Curdumin of metabolic Curcumin and Diabetes, oxidative stress, Apple cider vinegar for cholesterol antioxidant Diabbetes in the plasma of streptozotocin-diabetic Diaebtes.
Rats received water and lab chow diet Presence Nutrição Energy-boosting foods, Paulínia, African Mango Extract Paulo, Brazil Natural metabolic support for athletes libitum throughout the 30 days of the experiment.
Louis, Missouri, USA dissolved in ahd. Normal rats received only citrate buffer. Diabtees this procedure, all Diabetfs animals were anesthetized Diwbetes isoflurane. Louis, Missouri, USA and metformin metformin hydrochloride; purity of The experiment also had a group of normal rats treated with yoghurt An.
The Guarana for mental focus treatments were given by gavage twice a day. During ajd experiment, body weight, food and water intake, and urinary Diiabetes were monitored over a DDiabetes of 24 Diabees every week. An wnd of urine was taken Ckrcumin determine glycosuria levels o-toluidine Diabets.
At the end of the Crucumin, the blood samples were Diabeges for the analysis of plasma levels Diabetws glucose, triacylglycerol, cholesterol Labtest Diagnostica SA, Diabrtes Santa, Minas Gerais, Braziland for the measurement Diaberes thiobarbituric acid reactive substances TBARSfluorescent advanced glycation end products Amdand the activity of the antioxidant enzyme Diabetws 1 PON anx.
Lipid peroxidation products, including malondialdehyde, Dlabetes measured in deproteinized plasma samples using the thiobarbituric acid TBA reaction [ Diabetfs ]. TBA All-natural superfood supplement substances TBARS were measured fluorometrically with excitation and emission wavelengths of Curcumjn nm, Diabtees.
We used Diabtees Sigma Aldrich, St. Louis, Missouri, USA Curcumni standard. The fluorescence relative Diahetes advanced glycation end products AGEs was Peppermint ice cream according to Zilin et al.
To plasma samples were added 1. The results were expressed Increase athletic endurance arbitrary units of Diabwtes. PON 1 activity was determined according to Diaetes et al. The activity was monitored by measuring aand absorbance at nm over a period of 5 min.
One-way analysis of variance ANOVA followed by the Student—Newman—Keuls test were used to compare the temporal inter-group differences in physiological and biochemical parameters as well as in the glycoxidative stress biomarkers TBARS, AGEs, PON 1.
Statistical analyses were performed using the program Graphpad Instat 3. Diabetic rats treated with metformin-enriched yoghurt for 30 days had a significant decrease in glycemia levels Fig. This reduction in glycemia explain the low levels of glucose excreted in the 24 h urine, as well as the decrease in urinary volume and water ingestion Table 1.
The decrease in glycemia in DM rats also reflected in minor levels of plasma fluorescent AGEs end products of protein glycation Fig. The treatment of STZ-diabetic rats with metformin partially restored dyslipidemia, since triacylglycerol Fig. The beneficial effects of metformin on lipid profile have been well described [ 10 ].
Metformin treatment also decreased the levels of TBARS biomarker of lipid peroxidation Fig. Improvements in the biomarkers of oxidative damage have been observed in STZ-diabetic rats treated with metformin [ 1112 ]. Ultimately, the activity of PON 1 increased in diabetic rats treated with metformin-enriched yoghurt Fig.
PON 1 circulates preferentially in association with HDL, and its antioxidant activity is related to its ability to hydrolyze lipid peroxides within lipoproteins, mainly LDL [ 1314 ].
Furthermore, Younis et al. In patients newly diagnosed with diabetes, treatment with metformin was able to restore the activity of PON 1 [ 16 ].
Biochemical and oxidative stress biomarkers of STZ-diabetic rats treated with curcumin alone or combined with metformin. Plasma levels of glucose Atriacylglycerol Bcholesterol CTBARS Dfluorescent AGEs Eand PON 1 activity F.
a Differences with NYOG; b differences with DYOG; c differences with DINS; d differences with DC 90 ; e differences with DM ; f differences with DC 90 DM By monitoring various physiological and biochemical parameters altered in diabetes, authors found many benefits of these treatments, mainly in the glycemic control, and in a dose-dependent response.
It must be highlighted that none of these curcumin doses caused toxicity in normal or diabetic rats. In the present study, STZ-diabetic rats treated with curcumin-enriched yoghurt for 30 days showed maintenance of the glycemia values throughout the experimental period, in comparison with the progressive increase in the glycemia of DYOG rats, demonstrating the beneficial effects of curcumin on glycemic control Fig.
This beneficial effect of curcumin helps to explain the decrease in glycosuria, urinary volume, and water intake in DC 90 rats Table 1.
The antihyperglycemic activity of curcumin can be associated to its potential to prevent inflammation and apoptosis of pancreatic beta cells, improving their function [ 18 ], as well as improving insulin responses and glucose tolerance [ 19 ].
The minor levels of fluorescent AGEs in the plasma of diabetic rats treated with curcumin-enriched yoghurt Fig. In addition, Sun et al. The treatment of diabetic rats with curcumin also decreased the plasma levels of TBARS Fig. The antioxidant power of curcumin per se [ 21 ] may explain its ability to inhibit lipid peroxidation; however, the improvement in glycemia control can also contribute to reduction in the formation of reactive oxygen species ROS and therefore decreases oxidative stress in DM.
The treatment of diabetic rats with curcumin-enriched yoghurt prevented the reduction in the activity of PON 1 Fig. It has been found that curcumin can increase the expression of PON 1 in the liver [ 22 ]; however, it cannot be overlooked that PON 1 activity was preserved due to protection against glycation events, since curcumin reduced the markers of glycoxidative stress.
Evidence indicated that glycation of PON 1 decreases its activity [ 23 ]. Curcumin also improved lipid profile, since the plasma levels of triacylglycerol Fig. The beneficial effects of curcumin on hyperlipidemia have been well described [ 224 ].
Considering all these findings, curcumin has appeared as an antioxidant of natural origin with a great potential to oppose the complications of DM.
In a retrospective cohort study with 72, participants patients with type 2 DM in transition to insulin therapyXu et al. In addition, most patients continued with the metformin therapy after insulin initiation. Moreover, two recent prospective observational studies performed by the global DISCOVER study program found that first-line treatments for patients with type 2 DM were mostly metformin mono-therapy and combinations of metformin with a sulfonylurea.
In addition, the most commonly prescribed second-line therapies for type 2 DM were combinations of metformin with a dipeptidyl peptidase-4 inhibitor or metformin with a sulfonylurea [ 26 ].
In this sense, the search for novel combined therapies based on natural medicines with the ability to improve the effectiveness of glycemic control promoted by metformin, and to delay or even avoid the transition to insulin therapy is of great interest. Having additional choices beyond combining classical antidiabetic agents, therapeutic options should be personalized to individual patient, combining efficacy, safety, lower costs, and minor risks of long-term complications, co-morbidities and mortality observed in diabetes [ 28 ].
In an interesting review by Gupta and collaborators [ 29 ], quantitative pharmacokinetics and qualitative pharmacodynamics interactions were seen in the associations between natural compounds and conventional antidiabetic drugs, including metformin.
Many combinations of metformin with natural preparations have shown additive effects, mainly related to the antihyperglycemic potentials. On the other hand, some combinations changed the bioavailability or the renal clearance of metformin, as well as caused hypoglycemia; these findings deserve caution and indicate the need for further investigations.
As far as we know, combinations of metformin with curcumin emphasizing improvements in the control of the symptoms and complications of DM have not yet been studied. In addition to various preclinical studies indicating that curcumin has the potential to ameliorate the symptoms of DM, substantiating clinical studies are also showing promising findings about the efficacy of this phytochemical on glycemic control.
A large randomized, double-blinded, placebo-controlled cohort with prediabetic individuals in progression to type 2 DM showed that 9-month treatment with curcumin six capsules per day, each capsule contained mg curcumin extract improved the pancreatic beta cell function and various biomarkers related to glycemic control, including fasting glycemia, glycemia after 2 h glucose load, and glycated hemoglobin [ 30 ].
In a randomized, placebo-controlled, single blinded, cross-over study, the supplementation with curcumin tablet containing mg curcumin, one single administration in healthy individuals, reduced postprandial rise in glucose and insulin serum concentrations [ 19 ].
Finally, in a recent review by Rivera-Mancía et al. The authors also suggested as future perspectives, the need for advances about the interactions of curcumin with conventional antidiabetic drugs, which may give rise to a new complementary therapy in the management of diabetes.
In this regard, the present study demonstrated that the beneficial effects of the combined therapy of metformin and curcumin on diabetes can be achieved via two strategies: i the best effects of the isolated treatments were maintained including the reduction in glycosuria and plasma AGEs levels curcumin and metformin effectsthe increase in the activity of PON 1 curcumin and metformin effectsand the reduction in glycemia metformin effect ; ii additive effects were reached, mainly by further decrease in plasma triacylglycerol, cholesterol, and TBARS, in which levels were minor compared to those of isolated treatments.
The main benefits achieved by combining metformin and curcumin were the antioxidant potential of this therapy, and the improvement of dyslipidemia. Corroborating our findings, Gutierres et al. Recently, Asadi et al. The authors observed that both treatments were effective in promoting protection of renal function, but only the treatment with curcumin was able to increase the activities of antioxidant enzymes, and attenuate oxidative stress in kidneys of diabetic rats.
Unfortunately, the authors did not investigate the protective potential of the combined therapy. In summary, these findings indicated curcumin as an interesting option to be used in combination with antidiabetic agents to manage the symptoms of diabetes and prevent its long-term complications, mainly those related to oxidative stress.
Taking into account that combination therapy of current antidiabetic agents with natural antioxidants having beneficial effects on diabetic disturbances might be an interesting strategy, the present study showed the additive effects of curcumin combined with metformin on decreasing dyslipidemia and glycoxidative stress in diabetic rats, in association with the maintenance of metformin effects on decreasing glycemia and the curcumin effects on increasing PON 1 activity.
To the best of our knowledge, by targeting not only hyperglycemia, but also oxidative stress and dyslipidemia, this study provides the first evidence about a promising therapeutic strategy by combining curcumin and metformin for the management of DM complications, especially the cardiovascular events.
Further research is needed to allow the understanding of the mechanisms of action of this combined therapy that result to the beneficial effects observed in diabetes.
Volpe CMO, Villar-Delfino PH, Dos Anjos PMF, Nogueira-Machado JA. Cellular death, reactive oxygen species ROS and diabetic complications. Cell Death Dis. Article Google Scholar.
: Curcumin and Diabetes| Latest news | A review of mice research published in November in Evidence-Based Complementary and Alternative Medicine cites studies that suggest curcumin may help lower A1C — a two- to three-month blood sugar average — insulin sensitivity, and fasting blood sugar, in addition to preventing weight gain. But a study published in April in the Indian Journal of Clinical Biochemistry found that human participants who supplemented their Glucophage metformin — a diabetes medication that helps lower blood sugar — with turmeric did lower their blood sugar, inflammation, and levels of oxidative stress. In another human study — this one a randomized controlled trial that was published in in Diabetes Care — a supplement of milligrams of curcumin daily was associated with a delay in participants progressing from prediabetes to type 2 diabetes. Researchers studied people for nine months and reported that at the end of the study, Furthermore, in the Diabetes Care study, curcumin notably appeared to help improve the function of beta cells, which research shows help produce the hormone insulin. Insulin is responsible for ferrying glucose to cells, but in type 2 diabetes, cells become insensitive to glucose, leading to high blood sugar. As the pancreas cranks out more insulin to try to lower blood sugar levels, blood sugar remains elevated because of insulin resistance — until it wanes in producing insulin because of beta cell dysfunction. It's not going to be a cure-all. RELATED: A Detailed Guide to Building a Type 2 Diabetes-Friendly Diet. If you're not taking diabetes medication, a supplement that you know is going to be safe and have those compounds you are looking for is worth looking into, she says, adding that the benefit of curcumin on beta cell function may result in hypoglycemia. Research cited in the aforementioned Evidence-Based Complementary and Alternative Medicine review also notes that potential side effect of turmeric. RELATED: 11 Vitamin-Packed Superfoods for People With Type 2 Diabetes. While most of the research on turmeric so far has involved turmeric supplements, you can also enjoy this slightly bitter herb in your food and drinks. But if you want to whip up your own cup from scratch, recipes abound online. Check out this one, which involves concocting this comforting tea with cinnamon and freshly ground pepper, among other flavorful ingredients. To keep it diabetes-friendly, swap the honey for a sprinkle of a lower-carb sweetener , such as Splenda or stevia. Get the recipe from Meghan Telpner. For a richer take on turmeric tea, try coconut golden milk. This recipe combines turmeric tea and unsweetened almond and coconut milk for a creamy drink you can jazz up with a dash of maple syrup or stevia. Just go easy on the sweeteners to avoid a blood sugar spike. Get the recipe from the Minimalist Baker. RELATED: The Best Sugar Substitutes for People With Type 2 Diabetes. Reap the satiating perks of chickpeas and the anti-inflammatory effects of turmeric with this party-ready dish. Give the bone-broth trend a try and get an anti-inflammatory boost to boot. In addition to turmeric, this bowl calls for fresh ingredients such as parsley, cabbage, and leeks. Get the recipe from Parsnips and Pastries. According to the U. Department of Agriculture, tofu offers protein, fiber , and few carbs and calories, making it a diabetes-friendly addition to your plate. This recipe adds in cumin, ground ginger , cayenne, chili powder, and other easy-to-find spices that ensure your meal will be anything but boring. Get the recipe from Running on Real Food. Additional reporting by Melinda Carstensen. Tumor necrosis factor becomes activated in the presence of high blood sugar that occurs with diabetes. Recent studies suggest that curcumin can block this activation, which helps reduce inflammation in the body. A randomized controlled trial found that supplementation of one gram of curcumin per day for eight weeks helped lower levels of tumor necrosis factor by an average of It is common for patients with diabetes to have fatty liver disease or other liver disorders. Research suggests that curcumin can help regulate liver enzymes that control the levels of lipids and glucose due to its anti-inflammatory properties. A meta-analysis of four randomized controlled trials found that daily supplementation of curcumin of one gram or more for eight weeks reduced levels of alanine aminotransferase by an average of Diabetes is often associated with dysfunction of adipose, or fat tissue, which controls the levels of glucose throughout the body. Adiponectin is a hormone primarily found in fat tissue that regulates blood sugar levels and the breakdown of fatty acids. In type 2 diabetes, secretion of adiponectin is disrupted and reduced due to high blood sugar levels. Curcumin can benefit adipose tissue dysregulation by regulating the secretion of adiponectin. Curcumin has the potential to help decrease inflammatory markers, such as tumor necrosis factor and nitric oxide, that cause irregular accumulation and activation of macrophages specialized cells involved in the detection and destruction of bacteria and other harmful organisms within adipose tissue, which disrupt the secretion of adiponectin. Diabetic neuropathy is a common symptom of diabetes characterized by injury to peripheral nerves that transmit signals to and from the arms and legs. Diabetic neuropathy results from injury to blood vessels that supply the nerves of the arms and legs. This is caused by widespread inflammation resulting from disrupted blood sugar levels. Elevated levels of inflammatory proteins called advanced glycation end products AGEs become altered by the presence of excess blood sugar and cause oxidative stress and chronic inflammation in diabetic neuropathy. Curcumin contains both phenols and flavonoids that can scavenge free radicals and slow the oxidative damage that occurs. Curcumin can also increase the activation of antioxidant enzymes, such as superoxide dismutase, to further combat free radicals. Diabetic nephropathy , also called diabetic kidney disease, affects the kidney's ability to filter and remove waste and fluid from the body. It is characterized by the presence of albumin in the urine, increased arterial blood pressure, and a decreased glomerular filtration rate, an indicator of proper kidney functioning. Curcumin can help manage diabetic nephropathy by promoting the clearance of creatine and urea from the body, decreasing the levels of albumin and enzymes in the urine, and regulating the activity of kidney enzymes. Vascular disease as a result of diabetes occurs from damage to both small and large blood vessels throughout the body caused by widespread inflammation. Studies suggest that curcumin can help reduce complications from diabetic vascular disease in a variety of different ways. These include suppressing accumulation of inflammatory AGE proteins and inhibiting activation of certain cells that promote oxidative stress and cell damage. Curcumin can also improve wound healing and formation of new blood vessels and reduce tumor necrosis factor that causes excessive contraction of blood vessels. Use of curcumin may also be beneficial for reducing other complications of type 2 diabetes, including musculoskeletal diseases by suppressing bone resorption and reducing enzymes that break down bone. Curcumin also helps skeletal muscles increase glucose uptake to reduce insulin resistance. Curcumin may also help reduce other complications associated with type 2 diabetes like erectile dysfunction and gastroparesis , a condition caused by delayed emptying of stomach contents, by decreasing levels of inflammation and oxidative stress. Bioavailability refers to the amount of a substance that can be absorbed that reaches the bloodstream for systemic circulation. Substances delivered directly into a vein through an IV have the highest bioavailability, but when substances are taken by mouth, their bioavailability decreases as they are digested and absorbed through the intestines. Taking curcumin by mouth does not necessarily mean someone can get its beneficial effects because curcumin has poor bioavailability due to poor absorption through the intestines, rapid metabolism it is broken down very quickly , and rapid elimination, where it is excreted from the body before it can exert its positive effects. Research suggests that these issues of absorption, metabolism, and elimination can be reduced by consuming curcumin with piperine, a chemical compound found in black pepper. While curcumin is generally considered safe to use, some negative side effects, including headache, nausea, diarrhea, rash, and yellow stool, have been reported. Curcumin may also have potential interactions with certain medications such as blood thinners anticoagulants , antibiotics, antidepressants, cardiovascular medications, and cancer drugs. Turmeric should not replace other treatment plans for diabetes prescribed by your doctor. Always make sure to ask your doctor about taking turmeric or any other forms of treatment or dietary supplements to ensure it is safe for you and will not interact with any medications you are taking. Any changes to your treatment regimen for managing diabetes should always be discussed with a healthcare professional, such as your primary care provider or endocrinologist. Pivari F, Mingione A, Brasacchio C, Soldati L. Curcumin and type 2 diabetes mellitus: prevention and treatment. doi: Hewlings SJ, Kalman DS. Curcumin: a review of its effects on human health. Yuan F, Dong H, Gong J, et al. A systematic review and meta-analysis of randomized controlled trials on the effects of turmeric and curcuminoids on blood lipids in adults with metabolic diseases. Adv Nutr. Panahi Y, Hosseini MS, Khalili N, Naimi E, Simental-Mendía LE, Majeed M, Sahebkar A. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomed Pharmacother. Mansour-Ghanaei F, Pourmasoumi M, Hadi A, Joukar F. Integr Med Res. Zhang DW, Fu M, Gao SH, Liu JL. Curcumin and diabetes: a systematic review. Evid Based Complement Alternat Med. |
| Frontiers | The Effects of Curcumin on Diabetes Mellitus: A Systematic Review | Metabolic syndrome includes insulin resistance , high blood sugar, high blood pressure, low high-density lipoprotein HDL cholesterol, high low-density lipoprotein LDL cholesterol, increased triglyceride levels , and obesity. Patients were asked to bring all capsules back at the follow-up visit at 3, 6, and 9 months for assessing their compliance. Team Nutrisense. Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Cardiovascular and Kidney Effects, Potential Mechanisms, and Clinical Applications. Patil T, Srinivasan M. The treatment of diabetic rats with curcumin also decreased the plasma levels of TBARS Fig. |
| Can turmeric help manage diabetes? Glucose management and more | Most research to date has focused on curcumin rather than whole turmeric. The authors of a review in the journal Evidence-based Complementary and Alternative Medicine compiled more than research papers on the connection between diabetes and curcumin. The results suggest that curcumin can help people with diabetes in different ways, which may include improving insulin resistance and cholesterol levels. The review paper above discusses studies in animals that have indicated that curcumin could have a positive effect on high blood sugar and improve insulin sensitivity. However, the authors also note contradictory research findings, which showed that curcumin had little effect on blood sugar. Taking turmeric or curcumin by mouth may help reduce blood sugar to more manageable levels in some people, but more research in humans is necessary to confirm this effect. Many studies have suggested that turmeric might also protect against the development of diabetes. A study in Diabetes Care found that people with prediabetes who took curcumin for 9 months were less likely to develop type 2 diabetes than those taking a placebo. The authors of the study also noted that curcumin appeared to improve the function of the beta cells that make insulin in the pancreas. These findings suggest that including turmeric or curcumin in the diet may help people with prediabetes slow down or reverse the development of this condition. Compounds such as curcumin may also help reduce the risk or severity of some diabetes-related complications:. In laboratory tests, rats with diabetes who consumed curcumin were less likely to have liver problems that those that did not. In a human trial , 63 people with acute coronary syndrome took a low dose of 45 milligrams mg per day of curcumin for 2 months. Diabetes appears to increase the risk of cardiovascular disease. Heart disease is the number one cause of premature death in people with diabetes, according to the Centers for Disease Control and Prevention CDC. High blood sugar levels can lead to nerve damage, which doctors refer to as neuropathy. Autonomic neuropathy affects body functions over which a person has no conscious control, such as digestion. Peripheral neuropathy can lead to pain, tingling, and a loss of sensation in the hands and feet. Some studies have suggested that turmeric may help prevent certain complications of diabetic neuropathy , including:. Curcumin may also help prevent or reduce the severity of:. Curcumin has also shown the potential to protect animals from diabetic vascular disease and, as a result, to speed wound healing. When a person with diabetes has a wound, it can take a long time to heal, and the person will have a higher risk of infection than someone without diabetes. These factors can lead to severe complications. In some cases, scientists have not yet confirmed that the benefits of turmeric that they have noted in animal models are transferable to humans, so more research is necessary. Scientists believe that type 1 diabetes occurs when the immune system attacks insulin-producing beta cells in the pancreas. A article noted that curcumin might adjust how the overactive immune system works in people with type 1 diabetes. This finding suggests that curcumin may help strengthen the immune system. It could also boost the action of immunomodulatory medicines that doctors prescribe to manage type 1 diabetes. According to the National Center for Complementary and Integrative Health NCCIH , turmeric appears to be safe, and people can include it in their diet regularly. However, if people consume too much turmeric or curcumin, they may experience the following signs and symptoms:. People with certain health conditions may also need to avoid turmeric as it could worsen their symptoms. Taking too much curcumin or turmeric for an extended period may also contribute to liver problems. Turmeric or curcumin might also increase the effects of other blood sugar medications, which could lead to hypoglycemia , or low blood sugar. People should talk to a doctor before increasing their intake of turmeric or curcumin and before taking turmeric or any other supplements for their symptoms. Learn more about the side effects, benefits, and risks of using turmeric. If people with diabetes add turmeric to their diet, it should supplement and not replace a comprehensive diabetes management plan. People with diabetes should use insulin or other medications as their doctor advises and take the following lifestyle measures to reduce the risk of complications:. A doctor will work with the individual to create a health plan that addresses their specific symptoms and needs. The doctor can also offer advice on the use of turmeric in food or as a supplement, but they may recommend consulting a dietitian for help with nutrition and meal planning. Turmeric contains compounds that may be useful for treating various conditions, some of which can occur alongside diabetes. According to the NCCIH, some studies have found that curcuminoids might:. We then compared our result to a diabetes study conducted in a large Thai cohort by Aekplakorn et al. In this study, risk scores were developed from a Thai cohort of 2, individuals The EGAT study identified a set of strong risk factors that accelerate the development of T2DM among the Thai population; these are old age, high BMI, high WC, hypertension, and history of diabetes in parent or sibling. We found that these factors also influenced our study see the health parameter of the subject at the baseline in Table 1. Our subjects are mostly of old age, with high BMI according to Asian standards , high WC, and some with hypertension and a history of diabetes in parent or sibling. When we analyzed data based on the instruction from the EGAT study, we found that the prediabetic subjects from our study were assigned with high-risk scores Supplementary Tables 4—6. When we followed the EGAT calculation, the estimated overall incidence rate normalized to a period of 12 months from our study would be We observed Therefore, we believe that the high conversion rates found in the present study are a common characteristic of Thai prediabetes. Several studies have shown that traditional Chinese herbs and dietary supplements may have potential antidiabetic activity 6 , 30 — Although promising, most of these studies could not be easily interpreted, quite often because of inadequate study designs, such as lack of randomized control trials 30 — 32 , small sample size 30 — 32 , or lack of safety information 30 — Our study was designed and set up specifically to overcome those previous problems. Our study showed that the curcumin extract can effectively prevent the prediabetic population from developing T2DM. Although we found that the results were quite remarkable, a longer trial may be required to see if the curcumin-treated prediabetic population will eventually develop T2DM. We found that a 9-month treatment of curcumin was rather safe. We have not found any significant adverse effect caused by curcumin treatment when compared to the placebo treatment. Despite losing some body weight and WC, all of the subjects treated with curcumin appeared to be healthy. Because of its benefits and safety, we propose that curcumin extract may be used for an intervention therapy for the prediabetic population. Clinical trial reg. NCT, clinicaltrials. This study was supported by a grant from Thai Traditional Medical Knowledge Fund and the Department for Development of Thai Traditional and Alternative Medicine, Ministry of Public Health to S. designed the study, screened and examined all the recruited subjects, researched and analyzed data, and wrote and reviewed the manuscript. analyzed data and performed the statistical analysis. and C. provided trial advice. designed the study and wrote and reviewed the manuscript. is the guarantor of this work and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. The authors thank the Thai Government Pharmaceutical Organization for the gift of the curcumin extract and placebo. The authors also thank all of the subjects for participating in this study and the team of the outpatient clinic at HRH Princess Maha Chakri Sirindhorn Medical Center of Srinakharinwirot University, Nakornnayok, Thailand. Sign In or Create an Account. Search Dropdown Menu. header search search input Search input auto suggest. filter your search All Content All Journals Diabetes Care. Advanced Search. User Tools Dropdown. Sign In. Skip Nav Destination Close navigation menu Article navigation. Volume 35, Issue Previous Article Next Article. RESEARCH DESIGN AND METHODS. Article Navigation. Curcumin Extract for Prevention of Type 2 Diabetes Somlak Chuengsamarn, MD ; Somlak Chuengsamarn, MD. Corresponding author: Somlak Chuengsamarn, somlukc hotmail. This Site. Google Scholar. Suthee Rattanamongkolgul, MD ; Suthee Rattanamongkolgul, MD. Rataya Luechapudiporn, PHD ; Rataya Luechapudiporn, PHD. Chada Phisalaphong, PHD ; Chada Phisalaphong, PHD. Siwanon Jirawatnotai, PHD Siwanon Jirawatnotai, PHD. Diabetes Care ;35 11 — Article history Received:. Get Permissions. toolbar search Search Dropdown Menu. toolbar search search input Search input auto suggest. Table 1 Baseline characteristics of subjects. View large. View Large. Table 2 Levels of blood chemistries indicating β-cell functions and obesity parameters. Figure 1. View large Download slide. Table 3 Number and percent of diabetic newly diagnosed subjects during following period. No potential conflicts of interest relevant to this article were reported. Global prevalence of diabetes: estimates for the year and projections for Search ADS. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology ESC. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. Diabetes Reduction Assessment With Ramipril and Rosiglitazone Medication DREAM Investigators. Effect of Rosiglitazone and Ramipril on beta-cell function in people with impaired glucose tolerance or impaired fasting glucose: the DREAM trial. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Curcumin prevents high fat diet induced insulin resistance and obesity via attenuating lipogenesis in liver and inflammatory pathway in adipocytes. Hypoglycemic effects of turmeric Curcuma longa L. rhizomes on genetically diabetic KK-Ay mice. Curcuminoids and sesquiterpenoids in turmeric Curcuma longa L. suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Since ancient times in India and China, it has been considered to treat illnesses such as dermatologic diseases, infection, stress, and depression 53 — The main part of the plant is the rhizomes, and the most prevalent active components are the curcuminoids curcumin, demethoxycurcumin, and bisdemethoxycurcumin 53 , 56 , Curcuminoids are nontoxic polyphenolic that exerts a wide range of biological activities 58 , 59 , such as the production of significant immunosuppressants that inhibit the production of IL-2 and IL This compound inhibits the expression of iNOS inducible nitric oxide synthase , COX-2 cyclooxygenase-2 , lipoxygenase-5, and many other pro-inflammatory cytokines, such as TNF-α, IL-1, IL-6, and IL-8 60 — Curcuminoids can also regulate apoptosis and suppress neurotoxic factors in macrophages and alveolar monocytes stimulated by lipopolysaccharides. Besides, it inhibits phosphorylation and degradation of IκBα nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha and activates the γ receptor mechanism activated by peroxisome proliferator, reducing inflammation pattern induced by NF-κB pathway 62 — The biological effects may include the inhibition of reactive oxygen species ROS production, playing a fundamental role, particularly for diseases related to oxidative stress and inflammation, such as DM 67 , Figure 3 shows some systemic effects of curcumin. Figure 3 Effects of curcumin. Curcumin can inhibit hyperglycemia, oxidative stress, and the inflammatory processes caused by Diabetes Mellitus, in addition, and consequently inhibits the systemic complications of this disease, such as hypertension, dyslipidemia, neuropathy, nephropathy, and endothelial dysfunction. As seen above, curcumin can exhibit a huge range of therapeutic possibilities; however, it presents low solubility and rapid metabolism limiting its absorption in the gastrointestinal tract and resulting in weak bioavailability. The weak bioavailability has been associated to its insolubility in the water and the increased degradation in alkaline solutions or crystallization in acidic environments 69 — When ingested orally, the bioavailability of curcumin can be influenced by the food matrix, like lipids and proteins. Most of it is excreted in the feces, and only a small part will be absorbed in the intestine, which still undergoes a fast metabolism in the liver and the plasma. A high conjugation rate via glucuronidation and sulfation is also largely converted to its water-soluble metabolites sulfates and glucuronides that are excreted in the urine, explaining its concentration has a very low level in the blood 72 — The low bioavailability leads to reduced serum concentrations, reducing the possibilities of producing positive health effects. Due to these reasons, in the last few years, several delivery methods have been developed to improve oral curcumin bioavailability 75 , Some pharmaceutical technologies, and combinations with other compounds, such as piperine or lecithin, are being considered as they increase curcumin´s solubility, extend its residence in plasma, and improve the pharmacokinetic profile and cell absorption. Different new delivery systems, such as solid lipid particles, micellar systems, or hydrophilic nanoparticles, can increase curcumin concentration up to 15 to 20 times. Moreover, endovenous use of curcumin is safe if used if the dose administered is lower than that used orally. In pregnant animals, curcumin showed to be safe, but further studies are needed to confirm its safety in pregnant women 79 , Curcumin is also a nontoxic, non-mutagenic, non-carcinogenic, non-photo toxic agent and considered safe at lower doses than oral doses in intravenous administration in humans. Nevertheless, some adverse effects are related to its consumption, such as dyspepsia, nausea, flatulence, and diarrhea. It was also demonstrated that turmeric could interact with some medications; it affects cytochromes P, and the pharmacokinetics of some conventional drugs such as anticoagulants, antibiotics, antidiabetics, cardiovascular drugs, anticancer drugs, and antidepressants are influenced by curcuminoids 52 , 80 — Several studies have investigated the effects of curcumin on diabetes. These studies are shown in Table 1 and discussed below. A Pilot Study performed in Mexico 28 showed evidence that dietary supplementation with curcumin can reduce oxidative stress in patients with non-diabetic or diabetic proteinuric CKD. Curcumin significantly improved the elimination of free radicals activity in individuals with non-diabetic proteinuric CKD and reduced the plasma levels of malondialdehyde MDA. However, its effects were limited; patients with diabetic proteinuric CKD treated with placebo showed a significant reduction in MDA content after the intervention. Curcumin treatment did not modify the antioxidant activity of glutathione peroxidase, glutathione reductase, erythrocyte superoxide dismutase SOD , and erythrocyte catalase, or to increase nuclear factor erythroid-derived 2 -like 2 Nrf2 activation in both patients with non-diabetic and diabetic proteinuric CKD. A study with a higher dose and longer follow-up is necessary to confirm these findings. Another study, which investigated the effect of nano-curcumin in T2DM individuals, was adequately randomized, with no significant loss of participants, and even with a dose that the authors considered low, the effects of curcumin were positive. The fasting blood glucose FBG , Hemoglobin A1c HbA1C , body mass index BMI , Estimated Average Glucose eAG , total cholesterol TC , LDL-c, HDL-c, and triglyceride TG were compared between the two groups after the intervention. Curcumin improved FBG, HbA1c, BMI, and eAG, but did not affect LDL-c, HDL-c, TG, and TC The results of Panahi et al. Future studies may assess the impact of these antioxidant effects on diabetic complications and cardiovascular outcomes. The treatment of T2DM patients with curcuminoid plus piperine resulted in a reduction in serum Lp a and an increase in HDL-c concentrations. These results are important because, until very recently, the possibilities of influencing Lp a were extremely limited. Serum concentrations of lipids including TC, LDL-c, HDL-c, TG, lipoprotein a Lp a , and non-HDL-c were investigated at the beginning and at the end of the trial and revealed significant reductions in serum TC, non-HDL-c, and Lp a levels, and increase in serum HDL-c levels in the curcuminoid group compared to the placebo. Therefore, curcuminoids plus piperine may be a useful supplement in treating dyslipidemia in patients with T2DM The trial results performed by Panahi et al. However, this study has insufficient information regarding standard-of-care treatment that may be involved in the lack of curcuminoid efficacy on some parameters measured, particularly hs-CRP. Second, dietary intake and physical activity were not assessed; nevertheless, by randomization, it is expected that these characteristics were distributed similarly in the study groups minimizing the risk of bias. Finally, the trial duration was short, and it would help assess the efficacy of curcuminoids in long-term trials. Positive effects of curcumin were also found by Adab et al. BMI, TC, TG, LDL-c, HDL-c, insulin, HbA1C, FBG, fasting serum insulin, Apolipoprotein A1 and B were evaluated at the beginning and after the period of intervention. The authors concluded that this intervention could be used as an adjunct therapy to reduce diabetes complications, atherosclerosis, and overweight. The limitations of this trial may include a short intervention duration and low sample size. The trial performed by Adibian et al. However, the authors suggest that higher sample sizes, longer duration, and different curcumin doses could lead to better outcomes. In the trial performed by Asadi et al. The study also showed a reduction in glycemia after 2 h Bs2hp , weight, and body mass index; however, these modifications were not significant. Meanwhile, the authors recognize some limitations: a short duration of follow-up, a single-dose trial, and low male participation. The randomized, double-blind placebo-controlled trial performed in Iran by Hodaei et al. However, this intervention had no effects on oxidative stress, serum insulin levels, IR, and HbA1c. The authors recognize that the study had a short duration of intervention and showed significant loss of patients. Srinivasan et al. The carotid-femoral pulse wave velocity PWV , left brachial-ankle PWV, aortic augmentation pressure, aortic augmentation index, and aortic augmentation index decrease significantly. The authors attributed the lack of statistical reduction in endothelial dysfunction markers as adiponectin, leptin, ICAM, and VCAM due to methodological analysis limitations. In the trial performed by Vanaie et al. The authors recognized some study limitations, such as small sample size and short intervention time. The treatment of patients with T2DM with nano-curcumin capsules showed a beneficial effect on depression and anxiety. Moreover, curcumin was safe and well-tolerated during the study However, these effects were minor, and no significant effect was observed for stress. The authors considered that the intervention might show better effects in the long term or higher supplementation doses. Funamoto et al. Besides, the authors noticed that leptin demonstrated a decreasing trend after administration of Theracurmin. The results of Shafabakhsh et al. Also, nano-curcumin intake upregulated gene expression of PPAR-γ and LDLR in PBMCs and increased total nitrite and total antioxidant capacity TAC levels without affecting GSH levels and gene expression of TGF-β. The authors concluded that this supplementation showed anti-inflammatory and antioxidant effects; however, they recognized some limitations in the trial, since they did not check compliance to nano-curcumin intake, and they were also unable to determine the effects of the administration on other biomarkers of oxidative stress and inflammation. Another clinical trial developed by Shafabakhsh et al. Furthermore, it was able to improve Pittsburgh Sleep Quality Index PSQI score. The clinical trial developed by Mokhtari et al. Therefore, the study revealed strengths, such as the first study that evaluated the effects of nano-curcumin on wound healing parameters and metabolic control in DFU patients. As DFU patients are susceptible to insulin resistance and cardiometabolic disorders, there was a good rationale for this project. However, the trial had few limitations, including the small sample size and the short intervention period. Furthermore, the authors could not assess the effects of curcumin supplementation on gene expression related to insulin resistance, lipid homeostasis, and inflammation in patients with DFU. The trials that met the eligibility criteria for this review showed that curcumin significantly improves insulin resistance, serum glucose levels, HbA1c, lipid profile, and inflammatory biomarkers in patients with T2DM. Despite this, as T2DM remains incurable, understanding the role of curcumin in this pathology may represent a new therapeutic target. T2DM has a multifactorial pathology and affects thousands of people worldwide. Its treatment consists of lifestyle changes, diet, physical activity, and therapies with medications for the rest of life. We suggest that more robust and rigorous randomized controlled clinical trials are carried out to establish the role of curcumin in the therapeutics of T2DM. Further inquiries can be directed to the corresponding author. All the authors contributed equally to the manuscript. All authors contributed to the article and approved the submitted version. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Federation, IDF Diabetes Atlas. Google Scholar. Patergnani S, Bouhamida E, Leo S, Pinton P, Rimessi A. Biomedicines 9 2 doi: PubMed Abstract CrossRef Full Text Google Scholar. Ghorbani Y, Schwenger KJP, Allard JP. Manipulation of Intestinal Microbiome as Potential Treatment for Insulin Resistance and Type 2 Diabetes. Eur J Nutr 1— Wittwer J, Bradley D. Clusterin and Its Role in Insulin Resistance and the Cardiometabolic Syndrome. Front Immunol Snelson M, de Pasquale C, Ekinci EI, Coughlan MT. Gut Microbiome, Prebiotics, Intestinal Permeability and Diabetes Complications. Best Pract Res Clin Endocrinol Metab Zhang P, Sun X, Jin H, Zhang FL, Guo ZN, Yang Y. Association Between Obesity Type and Common Vascular and Metabolic Diseases: A Cross-Sectional Study. Front Endocrinol CrossRef Full Text Google Scholar. Sousa RAL, Improta-Caria AC, Souza BSF. Exercise-Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes. Int J Mol Sci 22 4 Adams JA, Uryash A, Lopez JR, Sackner MA. The Endothelium as a Therapeutic Target in Diabetes: A Narrative Review and Perspective. Front Physiol Shen CY, Lu CH, Wu CH, Li KJ, Kuo YM, Hsieh SC, et al. The Development of Maillard Reaction, and Advanced Glycation End Product Age -Receptor for AGE Rage Signaling Inhibitors as Novel Therapeutic Strategies for Patients With AGE-Related Diseases. Molecules Basel Switzerland 25 23 Salvatore T, Pafundi PC, Galiero R, Rinaldi L, Caturano A, Vetrano E, et al. Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects? Biomedicines 9 1 Tafrihi M, Imran M, Tufail T, Gondal TA, Caruso G, Sharma S, et al. The Wonderful Activities of the Genus Mentha: Not Only Antioxidant Properties. Molecules Basel Switzerland 26 4 Asbaghi O, Kashkooli S, Mardani M, Rezaei Kelishadi M, Fry H, Kazemi M, et al. Effect of Green Coffee Bean Extract Supplementation on Liver Function and Inflammatory Biomarkers: A Meta-Analysis of Randomized Clinical Trials. Complement Therapies Clin Pract Matias JN, Achete G, Campanari G, Guiguer É L, Araújo AC, Buglio DS, et al. A Systematic Review of the Antidepressant Effects of Curcumin: Beyond Monoamines Theory. Aust New Z J Psychiatry Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, et al. Curcumin, the Golden Nutraceutical: Multitargeting for Multiple Chronic Diseases. Br J Pharmacol — Perrone D, Ardito F, Giannatempo G, Dioguardi M, Troiano G, Lo Russo L, et al. Biological and Therapeutic Activities, and Anticancer Properties of Curcumin. Exp Ther Med — Drugs and Lactation Database Lactmed. Bethesda MD: National Library of Medicine US Sultana S, Munir N, Mahmood Z, Riaz M, Akram M, Rebezov M, et al. Molecular Targets for the Management of Cancer Using Curcuma Longa Linn. Phytoconstituents: A Review. Hajavi J, Momtazi AA, Johnston TP, Banach M, Majeed M, Sahebkar A. Curcumin: A Naturally Occurring Modulator of Adipokines in Diabetes. J Cell Biochem — Katsiki N, Mikhailidis DP, Banach M. Leptin, Cardiovascular Diseases and Type 2 Diabetes Mellitus. Acta Pharmacol Sin — |
| Curcumin Extract for Prevention of Type 2 Diabetes | Diabetes Care | American Diabetes Association | We avoid using tertiary Guarana for mental focus. Curcumin and Type 2 Annd Mellitus: Prevention wnd Treatment. If you're not taking diabetes medication, Curfumin Nutrient-rich weight management that you know Supercharged antioxidant veggies going to be safe aand have Curcumin and Diabetes compounds you are looking for is worth looking into, she says, adding that the benefit of curcumin on beta cell function may result in hypoglycemia. The inflammatory process likely contributes to the development of T2DM and may cause insulin resistance which is worsened with hyperglycemia 4. Pivari F, Mingione A, Brasacchio C and Soldati L: Curcumin and type 2 diabetes mellitus: Prevention and treatment. International Journal of Molecular Medicine, 47, |
| Can Turmeric Help Manage or Prevent Diabetes? | Joint pain, especially in the knee, due to arthritis affects about 1 in 10 older Americans. Research finds that an ingredient in the spice turmeric…. Cinnamon is a delicious spice with impressive effects on health and metabolism. Here are 10 evidence-based health benefits of cinnamon. However, eating too much could cause these 6 side effects. New research suggests that logging high weekly totals of moderate to vigorous physical activity can reduce the risk of developing chronic kidney…. Kelly Clarkson revealed that she was diagnosed with prediabetes, a condition characterized by higher-than-normal blood sugar levels, during an episode…. New research has revealed that diabetes remission is associated with a lower risk of cardiovascular disease and chronic kidney disease. Type 2…. A Quiz for Teens Are You a Workaholic? How Well Do You Sleep? Health Conditions Discover Plan Connect. Type 2 Diabetes. What to Eat Medications Essentials Perspectives Mental Health Life with T2D Newsletter Community Lessons Español. Can Turmeric Help Manage or Prevent Diabetes? Medically reviewed by Natalie Butler, R. Share on Pinterest. What are the benefits of turmeric? What the research says. Risks and warnings. Other ways to manage diabetes. The bottom line. How we reviewed this article: Sources. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. May 19, Written By Traci Angel. Sep 22, Medically Reviewed By Natalie Butler, RD, LD. Share this article. Read this next. Eating Turmeric May Help Knee Arthritis: What to Know About Food vs. Supplements Joint pain, especially in the knee, due to arthritis affects about 1 in 10 older Americans. Research finds that an ingredient in the spice turmeric… READ MORE. The 1-Hour Effects of Eating a Chocolate Chip Clif Bar. Medically reviewed by Peggy Pletcher, M. Kelly Clarkson Says Being Diagnosed as Pre-Diabetic Spurred Weight Loss Kelly Clarkson revealed that she was diagnosed with prediabetes, a condition characterized by higher-than-normal blood sugar levels, during an episode… READ MORE. Many studies have suggested that turmeric might also protect against the development of diabetes. A study in Diabetes Care found that people with prediabetes who took curcumin for 9 months were less likely to develop type 2 diabetes than those taking a placebo. The authors of the study also noted that curcumin appeared to improve the function of the beta cells that make insulin in the pancreas. These findings suggest that including turmeric or curcumin in the diet may help people with prediabetes slow down or reverse the development of this condition. Compounds such as curcumin may also help reduce the risk or severity of some diabetes-related complications:. In laboratory tests, rats with diabetes who consumed curcumin were less likely to have liver problems that those that did not. In a human trial , 63 people with acute coronary syndrome took a low dose of 45 milligrams mg per day of curcumin for 2 months. Diabetes appears to increase the risk of cardiovascular disease. Heart disease is the number one cause of premature death in people with diabetes, according to the Centers for Disease Control and Prevention CDC. High blood sugar levels can lead to nerve damage, which doctors refer to as neuropathy. Autonomic neuropathy affects body functions over which a person has no conscious control, such as digestion. Peripheral neuropathy can lead to pain, tingling, and a loss of sensation in the hands and feet. Some studies have suggested that turmeric may help prevent certain complications of diabetic neuropathy , including:. Curcumin may also help prevent or reduce the severity of:. Curcumin has also shown the potential to protect animals from diabetic vascular disease and, as a result, to speed wound healing. When a person with diabetes has a wound, it can take a long time to heal, and the person will have a higher risk of infection than someone without diabetes. These factors can lead to severe complications. In some cases, scientists have not yet confirmed that the benefits of turmeric that they have noted in animal models are transferable to humans, so more research is necessary. Scientists believe that type 1 diabetes occurs when the immune system attacks insulin-producing beta cells in the pancreas. A article noted that curcumin might adjust how the overactive immune system works in people with type 1 diabetes. This finding suggests that curcumin may help strengthen the immune system. It could also boost the action of immunomodulatory medicines that doctors prescribe to manage type 1 diabetes. According to the National Center for Complementary and Integrative Health NCCIH , turmeric appears to be safe, and people can include it in their diet regularly. However, if people consume too much turmeric or curcumin, they may experience the following signs and symptoms:. People with certain health conditions may also need to avoid turmeric as it could worsen their symptoms. Taking too much curcumin or turmeric for an extended period may also contribute to liver problems. Turmeric or curcumin might also increase the effects of other blood sugar medications, which could lead to hypoglycemia , or low blood sugar. People should talk to a doctor before increasing their intake of turmeric or curcumin and before taking turmeric or any other supplements for their symptoms. Learn more about the side effects, benefits, and risks of using turmeric. If people with diabetes add turmeric to their diet, it should supplement and not replace a comprehensive diabetes management plan. People with diabetes should use insulin or other medications as their doctor advises and take the following lifestyle measures to reduce the risk of complications:. A doctor will work with the individual to create a health plan that addresses their specific symptoms and needs. The doctor can also offer advice on the use of turmeric in food or as a supplement, but they may recommend consulting a dietitian for help with nutrition and meal planning. Turmeric contains compounds that may be useful for treating various conditions, some of which can occur alongside diabetes. According to the NCCIH, some studies have found that curcuminoids might:. Research has also suggested that turmeric may help with:. Learn more here about how turmeric can benefit a person with psoriasis. It is best to test the flavor by adding just 1 teaspoon of turmeric first. A person can then add another teaspoon if they want a stronger taste. Research suggests that curcumin, the main active ingredient in turmeric, can have a significant effect on some of the symptoms and complications of diabetes. However, most research to date has involved animals, and more human trials are necessary to confirm the benefits of this spice. In , one team of researchers urged caution over proposing turmeric as a cure-all. They called for more detailed studies, noting that because turmeric varies widely in quality, like other spices, it is difficult to carry out consistent tests. Turmeric is not a medication, and it is not a replacement for any drug or lifestyle measure that a doctor may prescribe to treat diabetes. People should not use it as a substitute for any aspect of diabetes care. However, under the guidance of a doctor, turmeric or curcumin may benefit a person with diabetes, whether they use it as a spice in cooking or take it in supplement form. We hear that turmeric is good for many things. Can it really help with diabetes and stop it from getting worse? Based on the current evidence, it seems that curcumin could be beneficial for people with diabetes or those wanting to prevent diabetes. Effective doses appear to range from 1, to 2, mg per day. It is a staple supplement in my regimen and one I recommend often. Natalie Butler, RD, LD Answers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice. Diabetes management includes artificial insulin and lifestyle adjustments. Read on to learn more. What are diabetic ulcers? Read on to learn more about this common diabetes complication, including causes, symptoms, treatment, and prevention options. Brittle diabetes is a rare form of diabetes that involves severe changes in blood sugar levels. Learn about its causes, risk factors, symptoms, and…. 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Curcumin and Diabetes -
This indicates that the anti-inflammatory properties of curcumin may be limited. There is evidence that turmeric may have a positive effect on blood sugar levels. A clinical trial found that curcumin decreased blood sugar by reducing serum free fatty acid levels in the blood.
A large amount of free fatty acids in your blood can increase your risk of cardiovascular disease, metabolic syndrome, obesity, and type 2 diabetes. The trial also found that curcumin increased fatty acid oxidation , the process of transforming fatty acids in the blood into metabolic energy.
In another clinical trial conducted in Thailand, people with prediabetes were randomly assigned to receive either curcumin or placebo capsules. After 9 months, about 16 percent of the placebo group was diagnosed with type 2 diabetes, while none of the participants in the curcumin group were.
A review of research published in also found evidence that curcumin could mitigate or prevent type 2 diabetes, hyperglycemia, insulin resistance, and hyperlipidemia in animals. While these studies are promising, there is a lot more work to be done to determine how turmeric can affect blood sugar.
At this time. more large-scale research and human trials are needed. When taken as a supplement, turmeric has been associated with an increased risk of kidney stones in some individuals. In Bangladesh, it was found that some sources of turmeric contained lead chromate , an additive that enhances its yellow color.
Lead chromate is a huge risk to human health and development. Lead has turned up in turmeric in the United States as well, and Consumer Reports has provided a list of turmeric supplement brands to avoid because they may contain this harmful substance.
Curcumin may also interact with some prescription drugs. If you are taking prescription medications, consult your doctor before taking a turmeric supplement. Remember to use caution when cooking with this spice, since it has a tendency to stain clothes and countertops.
Golden milk, or turmeric milk, is a popular and nourishing drink originating in India. Try out this recipe to add more turmeric to your diet. This flavorful dish is full of flavor and bright in color. Cauliflower is also a great source of fiber , which can support healthy glucose levels.
This chickpea curry is filled with dietary fiber, beneficial herbs and spices , B vitamins, and plant-based protein. Try whipping this up for dinner and enjoy the delicious flavors.
Start your day with antioxidants and protein with this simple breakfast dish. Replace the sourdough with whole grain bread for even more benefits.
Your blood sugar levels can significantly impact how your body feels and functions. When you join the Nutrisense CGM program , our team of credentialed dietitians and nutritionists are available for additional support and guidance to help you reach your goals.
Ready to take the first step? Start with our quiz to see how Nutrisense can support your health. Heather is a Registered and Licensed Dietitian Nutritionist RDN, LDN , subject matter expert, and technical writer, with a master's degree in nutrition science from Bastyr University.
She has a specialty in neuroendocrinology and has been working in the field of nutrition—including nutrition research, education, medical writing, and clinical integrative and functional nutrition—for over 15 years. How It Works Nutritionists Journal. What Is A CGM? Get Started. Promo code SPRING will be automatically applied at checkout!
Does Turmeric Help Lower Blood Sugar? Team Nutrisense. Share on Twitter. Share on Facebook. Share via Email. Reviewed by. Heather Davis, MS, RDN, LDN.
The Health Benefits of Turmeric Like many other herbs and spices , turmeric has been used to treat various health conditions for centuries. Cholesterol and Cardiovascular Health. Related Article. Read More. Engage with Your Blood Glucose Levels with Nutrisense Your blood sugar levels can significantly impact how your body feels and functions.
Take Our Quiz. Reviewed by: Heather Davis, MS, RDN, LDN. The expression of Bcl-2 and Bax in the retina was assessed by western blot analysis and immunohistochemistry.
Compared with the control group, Bax expression in the retinae of rats in the experimental group was downregulated, and Bcl-2 expression was significantly increased.
This suggested that curcumin played a role in inhibiting apoptosis, and can therefore exert a protective effect against DR Anti-apoptotic and pro-autophagic effects of curcumin.
Curcumin can upregulate the level of Nrf2 to induce the expression of HO-1, and it also plays an anti-apoptotic role by downregulating the levels of BAX, p62, and AMPK-mTOR, and phosphorylating Bcl-2 through AMPK and JNK1 pathways. This way, curcumin can enhance autophagy and protect cells from further damage.
Nrf2, nuclear factor E2-related factor 2; HO-1, heme oxygenase-1; AMPK, AMP-activated protein kinase; mTOR, mammalian target of rapamycin; JNK1, c-Jun N-terminal kinase; LC3, light chain 3; UVRAG, ultraviolet radiation resistance-associated gene protein; ATG5, autophagy-related protein 5.
Curcumin can also reduce insulin resistance in the diabetic state, and it has been proven to induce autophagy in gastric cancer cells. This effect is ROS concentration-dependent, suggesting that the control of ER stress by curcumin may be achieved by regulating the ROS level Some scholars have found that curcumin can inhibit ER stress in HUVECs and enhance autophagy, which may maintain ER homeostasis by degrading denatured and damaged proteins In the same vein, curcumin reduced the expression of p62 and enhanced the autophagy of podocytes in a high-glucose culture, thus exerting a protective effect on cells Yao et al found that in mice with diabetic cardiomyopathy induced by a high-fat diet combined with a low-dose STZ injection, the apoptosis of cardiac cells increased, and autophagy was inhibited Curcumin phosphorylated Bcl-2 by activating the AMP-activated protein kinase AMPK and c-Jun N-terminal kinase-1 JNK1 pathways, and then destroyed their interaction with Beclin-1; the AMPK-mammalian target of rapamycin mTOR pathway was also inhibited; both these effects ultimately promoted autophagy and reduced apoptosis, thus the protecting cells Therefore, it can be hypothesized that the protective effects of curcumin on DR involve the reduction of abnormal apoptosis of the retinal tissue in a high-glucose state by regulating the level of apoptosis-related proteins.
On the contrary, by properly enhancing autophagy and removing denatured and damaged proteins, curcumin can reduce the damage to the retinal barrier and the state of vascular leakage. In parallel, it can restore the normal level of apoptosis and reduce the damage to the retina caused by high glucose.
Hyperglycemia has been inevitably implicated as the main cause of DR. In addition to increasing the production of ROS through the autoxidation of glucose in a hyperglycemic environment, oxidative stress is also associated with hyperglycemia-induced metabolic pathways in DR.
With an increase in the glucose concentration, NF-κB, one of the key mediators of pro-inflammation, is also constantly activated. Moreover, high glucose levels can induce the oxidative stress pathway, promote the production of multiple free radicals and participate in the pathogenic mechanisms of DR Although hyperglycemia is the main cause of DR, hyperlipidemia is also considered to play a decisive role in its pathogenesis.
Triglyceride levels are directly related to the incidence and severity of DR, and long-term lipid-lowering therapy can reduce the need for laser therapy for patients with DR In recent years, an increasing number of studies have investigated lipids in association with diabetes.
For DR, an abnormal vascular endothelial function leads to increased plasma exudation, and the lipids themselves aggravate endothelial cell damage In diabetic rat models, the development of DR has been found to be enhanced in a hyperlipidemic environment, and the combination of hyperlipidemia and hyperglycemia enhances the activation of the apoptotic pathway in retinal capillary cells by accelerating mitochondrial damage Curcumin may also play a direct role in reducing blood glucose levels Fig.
After a 4-week follow-up, they found that compared with the placebo, curcumin supplementation effectively reduced the fasting blood glucose concentration of individuals with a certain degree of blood glucose abnormality, but not that of non-diabetic individuals In mice and rat models of diabetes, curcumin and its synthetic analogs have been found to significantly reduce the level of blood glucose and glycosylated hemoglobin, improve the function of β cells, prevent β cell death - , reduce insulin resistance, and delay the occurrence and progression of diabetes Moreover, the therapeutic effect of curcumin has been shown to be more prominent when bioavailability enhancers, such as piperine are used Kato et al found curcumin to promote the level of glucagon-like peptide 1 GLP-1 and to play a hypoglycemic role in a rat model in which curcumin was administered and glucose was then injected intraperitoneally to improve glucose tolerance These findings demonstrate that curcumin has the biological function of promoting GLP-1 secretion, and the curcumin-induced increase in endogenous GLP-1 secretion may reduce the required dosage of other diabetic drugs and help prevent diabetes and related complications Anti-hyperglycemic and anti-hyperlipidemic effects of curcumin.
Curcumin can enhance the level of GLP-1 to improve glucose tolerance and reduce triglycerides by regulating the level of lipoproteins. It can also control insulin resistance by lowering blood glucose and glycosylated hemoglobin levels.
These effects can ultimately delay the progression of diabetes and DR by down-regulating serum cholesterol and lipid peroxides. DR, diabetic retinopathy; GLP-1, glucagon-like peptide-1; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol.
Several studies have also revealed that curcumin is a natural lipid regulator Fig. In a randomized, placebo-controlled, double-blind trial, half of the patients with metabolic syndrome received curcumin extract capsules for 12 weeks.
The results revealed a significant increase in high-density lipoprotein cholesterol HDL-C and a significant decrease in low-density lipoprotein cholesterol LDL-C , accompanied by a significant decrease in triglyceride levels This cholesterol-lowering effect is believed to be related to the upregulation of LDL receptors following the administration of curcumin - Soni and Kuttan also conducted an experiment on the effect of curcumin administration on the reduction of serum cholesterol and lipid peroxide levels It was found that healthy individuals who received mg of curcumin daily for 7 days also exhibited a decrease in serum lipid peroxide and total cholesterol levels and an increase in HDL-C Of note, in the serum results of New Zealand white rabbits fed a curcumin diet for 8 weeks, Um et al demonstrated that curcumin can indeed reduce the level of total cholesterol and low-density lipoprotein, but it cannot affect the level of high-density lipoprotein.
The latter may be related to the concomitant cholesterol diet In light of these findings, taken together, it can be concluded that curcumin can reduce blood glucose and blood lipid in many ways, and thus improve the symptoms of diabetes and DR.
DR represents one of the severe microvascular complications of diabetes mellitus. Its underlying pathogenic mechanisms represent a complex process characterized by multi-factorial participation, multigenic regulation, and multi-step evolutionary processes.
A variety of mechanisms jointly contribute to the occurrence and progression of DR. Due to the large number of patients with DR worldwide, particularly individuals of working-age, increasing attention is being paid to DR as a severe eye disease that leads to blindness.
It has been found that curcumin can improve glucose and lipid metabolism, improve insulin sensitivity, reduce insulin resistance, and improve oxidative stress and inflammatory pathway conditions in diabetes and DR. In the future, further clinical trials may be designed to assess whether the bioavailability of curcumin could be improved by combining it with other available therapies.
The regulatory effects of curcumin on autophagy and apoptosis may provide insight for the development of novel therapeutics for DR. Further studies are required to explore the therapeutic potential of curcumin and evaluate whether it can be used as a novel drug for DR in clinical practice.
JY, XM and FJY were involved in the conception of the study, and in the writing and preparation of the manuscript, as well as in the supervision of figure preparation. JY, JFC and XL were involved in the writing of the manuscript and preparation of the figures.
JY, JLF and GFS were involved in the writing and supervision of the manuscript. This study was supported by the National Natural Science Foundation , the International Cooperation Project of Science and Technology Department of Jilin Province GH , Training Program for Outstanding Young Teachers of Jilin University , and the Natural Science Foundation Project of Science and Technology Department of Jilin Province JC.
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Fat burner facts than Guarana for mental focus Diaetes Americans have diabetes. Crcumin around 1 ahd 10 adults, Dibaetes it's a condition that's becoming more common. If left untreated, it can cause Nutrient-rich weight management disease, increase Diabetss risk Diaetes heart disease, and even cause blindness. For many, the condition is manageable through diet and exercise. Others may need additional treatment support through oral medication or insulin injections. By consistently monitoring blood sugar levels, it's possible to avoid many of the long-term risks associated with diabetes and live a long and healthy life. There are numerous methods to control diabetic symptomsbut researchers continue to study alternative strategies to prevent and treat diabetes in all its forms.
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